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1.发明申请Lactones of carboxylic acid polysaccharides and methods for forming conjugates thereof 审中-公开羧酸多糖的内酯及其共轭物的形成方法公开(公告)号：US20060235211A1
公开(公告)日：2006-10-19
申请号：US11408750
申请日：2006-04-21
Applicant: Ned Heindel , Wallace Longton , Christine Martey-Ochola , Robert Rapp
Inventor： Ned Heindel , Wallace Longton , Christine Martey-Ochola , Robert Rapp
CPC classification number: C08B37/0045 , C07H17/02 , C08B11/12 , C08B11/20 , C08B15/00 , C08B31/00 , C08B31/12 , C08B37/0012 , C08B37/003
Abstract: Novel lactones of polysaccharide carboxylic acids, and methods for the preparation of a variety of conjugates therefrom, as well as the novel conjugates, are provided. Conjugates include metallo-coordinated cisplatin (and carboplatin), as well as conjugates of ellipticinium, aminoglutethimide, mitoxantrone, mitoguazone, cis 3-hexen-1-ol, and other nucleophilic biologically effective agents. Also provided are conjugates via a coupling agent of biologically effective agents, such as Vitamin E, DTPA, TAXOL and TAXOTERE.
Abstract translation: 提供了多糖羧酸的新型内酯，以及从其制备各种缀合物的方法以及新颖的缀合物。 缀合物包括金属配位顺铂（和卡铂），以及椭圆ium碱，氨基十八烷基亚胺，米托蒽醌，丝瓜多嗪，顺式3-己烯-1-醇和其他亲核生物有效药物的结合物。 还提供了经由生物有效试剂如维生素E，DTPA，TAXOL和TAXOTERE的偶联剂的缀合物。
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公开(公告)号：US20060217364A1
公开(公告)日：2006-09-28
申请号：US11442788
申请日：2006-05-30
Applicant: Robert Bruns , Christophe Guillon , Ned Heindel , Gary Koppel , Marvin Miller
Inventor： Robert Bruns , Christophe Guillon , Ned Heindel , Gary Koppel , Marvin Miller
IPC: A61K31/4178 , A61K31/4025 , C07D403/02
CPC classification number: C07D413/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/04 , C07D417/14
Abstract: Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor.
Abstract translation: 描述了新的2-（氮杂环丁烷-2-对-1-基）烷二酸衍生物和2-（氮杂环丁-2-酮-1-基）烷氧基烷酸衍生物用于治疗对加压素拮抗作用有反应的疾病状态 V 1a受体。
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3.发明申请Fluorescent fused-ring triazoles that inhibit cell proliferation and uses thereof 有权抑制细胞增殖的荧光稠环三唑和其用途公开(公告)号：US20060040926A1
公开(公告)日：2006-02-23
申请号：US10922300
申请日：2004-08-19
Applicant: Jeffrey Laskin , Ned Heindel , Diane Heck , Anna Vetrano , Christophe Guillon , Peter DeMatteo
Inventor： Jeffrey Laskin , Ned Heindel , Diane Heck , Anna Vetrano , Christophe Guillon , Peter DeMatteo
IPC: A61K31/549 , C07D498/04
CPC classification number: C07D513/04
Abstract: Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.
Abstract translation: 提供了抑制细胞增殖并表现出独特和强烈荧光的融合环三唑化合物。 还提供了合成这些化合物的方法和使用这些化合物抑制细胞增殖和感染以及标记和荧光检测所选择的分子的方法。
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公开(公告)号：US20060281728A1
公开(公告)日：2006-12-14
申请号：US10573732
申请日：2004-10-01
Applicant: Christophe Guillon , Ned Heindel , Gary Koppel , Marvin Miller
Inventor： Christophe Guillon , Ned Heindel , Gary Koppel , Marvin Miller
IPC: A61K31/422 , A61K31/4178 , A61K31/4025 , A61K31/397 , C07D417/02 , C07D413/02 , C07D403/02
CPC classification number: C07D413/14 , C07D205/085 , C07D413/04
Abstract: Novel 2-(azetidin-2-on-1-yl)alkanedioic acids and derivatives thereof are described. Methods for using 2-(azetidin-2-on-1-yl)alkanedioic acids and derivatives thereof in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor are also described.
Abstract translation: 描述了新的2-（氮杂环丁烷-2-基-1-基）链烷二酸及其衍生物。 还描述了使用2-（氮杂环丁烷-2-酮-1-基）链烷二酸及其衍生物治疗对加压素V 1a受体的拮抗作用有反应的疾病状态的方法。
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Patent Agency Ranking
公开(公告)号：US20120010168A1
公开(公告)日：2012-01-12
申请号：US13127284
申请日：2009-11-03
Applicant: Jeffrey Laskin , Diane Heck , Mou-Tuan Huan , Karine Fabio , C. Jeffrey Lacey , Sherri Young , Pramod Mohanta , Christophe Guillon , Ned Heindel
Inventor： Jeffrey Laskin , Diane Heck , Mou-Tuan Huan , Karine Fabio , C. Jeffrey Lacey , Sherri Young , Pramod Mohanta , Christophe Guillon , Ned Heindel
IPC: A61K31/695 , C07C69/96 , A61P29/00 , C07D209/26 , A61K31/404 , C07F7/10 , A61K31/265
CPC classification number: C07F7/0812 , A61K9/0014 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K47/54 , A61K47/55 , C07C69/96 , C07C229/42 , C07C2602/10 , C07D209/28 , C07F7/081
Abstract: A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X═C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.
Abstract translation: 本文公开了一种新的治疗系列，其在酯或酯 - 碳酸酯骨架上提供用于非甾体抗炎剂的受控释放递送平台。 这些试剂是乙酰胆碱酯酶的可逆抑制剂，因此可用于有益于炎症抑制和胆碱能干预的临床病症。 这些化合物具有以下通式：其中n = 0,1; X = C，Si，N +和NSAID =布洛芬，萘普生，吲哚美辛和双氯芬酸。 还公开了其他实施例。
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6.发明授权Fluorescent fused-ring traizoles that inhibit cell proliferation and uses thereof 失效抑制细胞增殖的荧光融合环状物及其用途公开(公告)号：US07598238B2
公开(公告)日：2009-10-06
申请号：US11495948
申请日：2006-07-28
Applicant: Jeffrey D. Laskin , Ned Heindel , Diane Heck , Anna Marie Vetrano , Christophe Guillon , Peter DeMatteo
Inventor： Jeffrey D. Laskin , Ned Heindel , Diane Heck , Anna Marie Vetrano , Christophe Guillon , Peter DeMatteo
IPC: C07D513/04 , A61K31/542
CPC classification number: C07D513/04
Abstract: Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.
Abstract translation: 提供了抑制细胞增殖并表现出独特和强烈荧光的融合环三唑化合物。 还提供了合成这些化合物的方法和使用这些化合物抑制细胞增殖和感染以及标记和荧光检测所选择的分子的方法。
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公开(公告)号：US07150967B2
公开(公告)日：2006-12-19
申请号：US10408170
申请日：2003-04-04
Applicant: Jeffrey D. Laskin , Christine Martey , Ned Heindel , Marilyn Whittemore , Diane Heck
Inventor： Jeffrey D. Laskin , Christine Martey , Ned Heindel , Marilyn Whittemore , Diane Heck
CPC classification number: G01N33/533
Abstract: Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluorescent reactions products of the mercurimethyl-dihydropsoralen compounds or derivatives thereof attached to a thiol containing species and nucleic acids fluorescently labeled with these reaction products are also provided.
Abstract translation: 提供了使用插入核酸并与含硫醇物质高反应性的二甲基 - 二氢补骨脂素化合物及其衍生物来标记和检测含硫醇物质和核酸的方法和试剂盒。 还提供了连接到含硫醇的物质的汞二甲基 - 二氢补骨脂素化合物或其衍生物和用这些反应产物荧光标记的核酸的荧光反应产物。
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公开(公告)号：US20060270664A1
公开(公告)日：2006-11-30
申请号：US11495948
申请日：2006-07-28
Applicant: Jeffrey Laskin , Ned Heindel , Diane Heck , Anna Vetrano , Christophe Guillon , Peter DeMatteo
Inventor： Jeffrey Laskin , Ned Heindel , Diane Heck , Anna Vetrano , Christophe Guillon , Peter DeMatteo
IPC: A61K31/549 , C07D498/04
CPC classification number: C07D513/04
Abstract: Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.
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公开(公告)号：US07105511B2
公开(公告)日：2006-09-12
申请号：US10922300
申请日：2004-08-19
Applicant: Jeffrey D. Laskin , Ned Heindel , Diane Heck , Anna Marie Vetrano , Christophe Guillon , Peter DeMatteo
Inventor： Jeffrey D. Laskin , Ned Heindel , Diane Heck , Anna Marie Vetrano , Christophe Guillon , Peter DeMatteo
IPC: C07D513/04 , A61K31/542 , A61P35/00
CPC classification number: C07D513/04
Abstract: Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.
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