公开(公告)号：US20060040926A1

公开(公告)日：2006-02-23

申请号：US10922300

申请日：2004-08-19

Applicant: Jeffrey Laskin ,  Ned Heindel ,  Diane Heck ,  Anna Vetrano ,  Christophe Guillon ,  Peter DeMatteo

Inventor： Jeffrey Laskin ,  Ned Heindel ,  Diane Heck ,  Anna Vetrano ,  Christophe Guillon ,  Peter DeMatteo

IPC: A61K31/549 ,  C07D498/04

CPC classification number: C07D513/04

Abstract: Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.

Abstract translation: 提供了抑制细胞增殖并表现出独特和强烈荧光的融合环三唑化合物。 还提供了合成这些化合物的方法和使用这些化合物抑制细胞增殖和感染以及标记和荧光检测所选择的分子的方法。

公开(公告)号：US20120010168A1

公开(公告)日：2012-01-12

申请号：US13127284

申请日：2009-11-03

Applicant: Jeffrey Laskin ,  Diane Heck ,  Mou-Tuan Huan ,  Karine Fabio ,  C. Jeffrey Lacey ,  Sherri Young ,  Pramod Mohanta ,  Christophe Guillon ,  Ned Heindel

Inventor： Jeffrey Laskin ,  Diane Heck ,  Mou-Tuan Huan ,  Karine Fabio ,  C. Jeffrey Lacey ,  Sherri Young ,  Pramod Mohanta ,  Christophe Guillon ,  Ned Heindel

IPC: A61K31/695 ,  C07C69/96 ,  A61P29/00 ,  C07D209/26 ,  A61K31/404 ,  C07F7/10 ,  A61K31/265

CPC classification number: C07F7/0812 ,  A61K9/0014 ,  A61K31/19 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/54 ,  A61K47/55 ,  C07C69/96 ,  C07C229/42 ,  C07C2602/10 ,  C07D209/28 ,  C07F7/081

Abstract: A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X═C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.

Abstract translation: 本文公开了一种新的治疗系列，其在酯或酯 - 碳酸酯骨架上提供用于非甾体抗炎剂的受控释放递送平台。 这些试剂是乙酰胆碱酯酶的可逆抑制剂，因此可用于有益于炎症抑制和胆碱能干预的临床病症。 这些化合物具有以下通式：其中n = 0,1; X = C，Si，N +和NSAID =布洛芬，萘普生，吲哚美辛和双氯芬酸。 还公开了其他实施例。

公开(公告)号：US20060270664A1

公开(公告)日：2006-11-30

申请号：US11495948

申请日：2006-07-28

Applicant: Jeffrey Laskin ,  Ned Heindel ,  Diane Heck ,  Anna Vetrano ,  Christophe Guillon ,  Peter DeMatteo

Inventor： Jeffrey Laskin ,  Ned Heindel ,  Diane Heck ,  Anna Vetrano ,  Christophe Guillon ,  Peter DeMatteo

IPC: A61K31/549 ,  C07D498/04

CPC classification number: C07D513/04

Abstract: Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.