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公开(公告)号：US09023797B2
公开(公告)日：2015-05-05
申请号：US13951070
申请日：2013-07-25
Applicant: Wytold Lebing , Doug Burns , Nathan Roth , Joann Hotta
Inventor： Wytold Lebing , Doug Burns , Nathan Roth , Joann Hotta
CPC classification number: A01N37/02 , C07K14/76 , C12N7/00 , C12N2760/20263 , C12N2770/24363
Abstract: Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.
Abstract translation: 本文描述了使用含有白蛋白的溶液中的辛酸盐灭活病毒的方法。
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公开(公告)号：US20140163101A1
公开(公告)日：2014-06-12
申请号：US13951070
申请日：2013-07-25
Applicant: Wytold Lebing , Doug Burns , Nathan Roth , Joann Hotta
Inventor： Wytold Lebing , Doug Burns , Nathan Roth , Joann Hotta
CPC classification number: A01N37/02 , C07K14/76 , C12N7/00 , C12N2760/20263 , C12N2770/24363
Abstract: Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.
Abstract translation: 本文描述了使用含有白蛋白的溶液中的辛酸酯灭活病毒的方法。
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公开(公告)号：US06333050B2
公开(公告)日：2001-12-25
申请号：US09764074
申请日：2001-01-19
Applicant: Patrick S.-L. Wong , Howard B. Rosen , Nathan Roth , Phyllis I. Gardner
Inventor： Patrick S.-L. Wong , Howard B. Rosen , Nathan Roth , Phyllis I. Gardner
IPC: A61K914
CPC classification number: A61K9/0092 , A47G21/183 , A61J7/0038
Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.
Abstract translation: 本发明涉及一种用于将活性剂制剂的离散单元递送至患者的口服活性剂递送系统和方法。 含有活性剂制剂并具有流体通过的活性剂制剂保持剂的活性剂制剂室在第一端置于流体中，并在第二端置于患者口中。 当患者在房间的第二端上浸泡时，递送活性剂。
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公开(公告)号：US5780058A
公开(公告)日：1998-07-14
申请号：US684602
申请日：1996-07-19
Applicant: Patrick S.-L. Wong , Howard B. Rosen , Nathan Roth , Phyllis I. Gardner
Inventor： Patrick S.-L. Wong , Howard B. Rosen , Nathan Roth , Phyllis I. Gardner
CPC classification number: A61K9/0092 , A47G21/183 , A61J7/0038
Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber (10) containing the active agent formulation and having a fluid passing active agent formulation retainer (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber.
Abstract translation: 本发明涉及一种用于将活性剂制剂的离散单元递送至患者的口服活性剂递送系统和方法。 含有活性剂制剂并具有流体通过的活性剂制剂保持器（14）的活性剂制剂室（10）在一端（16）处放置成流体，并在第二端（18）放置到患者口中。 当患者唾液在腔室的末端时，递送活性剂。
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公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
Applicant: Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
Inventor： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC: A61N1/30
CPC classification number: A61N1/0436 , A61N1/0448 , A61N1/044
Abstract: A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).
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Patent Agency Ranking
公开(公告)号：US4929233A
公开(公告)日：1990-05-29
申请号：US236974
申请日：1988-08-26
Applicant: Nathan Roth , Su I. Yum
Inventor： Nathan Roth , Su I. Yum
CPC classification number: A61K9/0004 , A61M5/1483
Abstract: An improved imbibing agent dispenser having a snap-on closure which is highly reliable, is simple to assemble on one end of the agent dispenser, and can be made at minimum expense without requiring heat or an adhesive to bond the closure to the dispenser. The closure is held in place on the dispenser by a locking feature formed by a shoulder on the end of the dispenser and a ledge on an outer, annular wall of the closure, the ledge being removably hooked beneath and biased toward the shoulder to releasably lock the closure to the dispenser. An important aspect of this closure is that the design provides for the complete containment of a solute component within the dispenser.
Abstract translation: 具有高可靠性的卡扣式闭合器的改进的吸液剂分配器易于组装在药剂分配器的一端，并且可以以最小的成本制成，而不需要热或粘合剂将封闭物结合到分配器。 封闭件通过由分配器的端部上的肩部形成的锁定特征保持在分配器上的位置以及在封闭件的外部环形壁上的凸缘，该凸缘可拆卸地钩在下面并朝向肩部偏压以可释放地锁定 关闭到分配器。 该封闭件的一个重要方面是设计提供了在分配器内完全容纳溶质成分。
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7.发明授权
公开(公告)号：US4828108A
公开(公告)日：1989-05-09
申请号：US209233
申请日：1988-06-20
Applicant: Nathan Roth , Andrew Nelsen
Inventor： Nathan Roth , Andrew Nelsen
CPC classification number: A61C19/06 , A61F15/001 , B65B9/073
Abstract: The package of the present invention comprises a sheath formed from a folded, relatively rigid strip having structure for receiving and releasably holding the ends of the fiber to be packaged. In a preferred embodiment, the fiber is between the two folded over parts of the strip with the ends of the fiber anchored in place in a pair of slits. The sheath is in a pouch formed by a pair of foil members on opposite sides of the sheath. When ready for use, the package is opened by peeling the foil members apart, thereby exposing the sheath and permitting access to the fiber carried by the sheath. An improved apparatus and method are provided to form the package. In the first instance, the sheath is prepared by first folding a strip of relatively rigid material, such as siliconized polyester, then moving the folded strip along a path of travel and feeding the fiber into the region between the parts of the strip as the strip moves. At a certain location along the path of the strip, the fiber is forced into each slit of the strip and the fiber becomes releasably attached to the strip. At another location, the strip is cut; thus, in this way, a plurality of sheaths with fiber lengths between the sides of the sheaths are formed and are immediately moved to a location where the foil members are applied to the opposite sides of the sheaths.
Abstract translation: 本发明的包装包括由折叠的相对刚性的条带形成的护套，其具有用于接收和可释放地保持要包装的纤维的端部的结构。 在优选实施例中，纤维位于条带的两个折叠部分之间，纤维的端部锚定在一对狭缝中。 护套在由护套的相对侧上的一对箔构件形成的袋中。 当准备使用时，通过剥离箔构件来打开包装，从而露出护套并允许进入由护套承载的纤维。 提供改进的装置和方法以形成包装。 首先，通过首先折叠相对刚性的材料（例如硅化聚酯）的条带来制备护套，然后沿着行进路径移动折叠的条带，并将纤维馈送到条带的部分之间的区域中，作为条带 移动。 在沿带的路径的某个位置处，纤维被迫进入条的每个狭缝中，并且纤维可释放地附接到条带上。 在另一个位置，切割条; 因此，以这种方式，形成在护套的侧面之间具有纤维长度的多个护套，并且立即移动到箔构件被施加到护套的相对侧的位置。
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公开(公告)号：US4019633A
公开(公告)日：1977-04-26
申请号：US597020
申请日：1975-07-18
Applicant: Nathan Roth
Inventor： Nathan Roth
CPC classification number: B65D5/0245 , A61F6/14 , A61F6/18 , B65D5/0209 , B65D5/503 , Y10S206/815
Abstract: A package for an intrauterine device-intrauterine device inserter combination and a "pillow pack" carton for the package are disclosed. The package consists of three elements: (1) a thermoformed plastic tray having an elongated, relatively deep cavity for holding the combination, a convexly curved marginal ledge about the cavity, an end wall extending downwardly from each end of the ledge, and a flange extending outwardly from the bottom of each end wall; (2) a cover that fits over the cavity and has the same curvature as the marginal ledge; and (3) an adhesive coating on the inner side of the cover by which the cover is attached to the ledge over the cavity. The package is enveloped in a paper carton that has a bottom wall on which the package bottom rests, a pair of end walls, each of which has an inwardly extending section that overlies one of the flanges of the package tray whereby the package is held firmly in place, and a pair of flaps that are foldably connected to the longitudinal edges of the bottom wall and fold over the top of the package in an overlapping, interlocking fashion.
Abstract translation: 公开了一种用于子宫内装置 - 子宫内装置插入器组合的包装和用于包装的“枕头包装”纸盒。 该包装由三个元件组成：（1）热成型塑料托盘，其具有用于保持该组合的细长相对较深的空腔，围绕该空腔的凸形弯曲的边缘，从壁架的每个端部向下延伸的端壁，以及凸缘 从每个端壁的底部向外延伸; （2）盖子，该盖子适合于空腔并具有与边缘相同的曲率; 和（3）在盖的内侧上的粘合剂涂层，通过该粘合剂涂层将盖附接到腔上的凸缘。 该包装被包装在纸盒中，该纸盒具有一个底壁，一个包装底部搁置着的底壁，一对端壁，每个端壁具有一个向内延伸的部分，该部分覆盖着包装托盘的一个凸缘， 以及一对可折叠地连接到底壁的纵向边缘并且以重叠的互锁方式折叠在包装的顶部上的折翼。
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公开(公告)号：US5985324A
公开(公告)日：1999-11-16
申请号：US73982
申请日：1998-05-07
Applicant: Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
Inventor： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
CPC classification number: A61J7/0038 , A47G21/183 , A61K9/0092
Abstract: The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
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公开(公告)号：US5910321A
公开(公告)日：1999-06-08
申请号：US949753
申请日：1997-10-14
Applicant: Patrick S.-L. Wong , Nathan Roth , Vincent J. Ferrari
Inventor： Patrick S.-L. Wong , Nathan Roth , Vincent J. Ferrari
CPC classification number: A61J7/0038 , A47G21/183 , A61K9/0004
Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
Abstract translation: 本发明涉及一种口服活性剂递送系统和用于将活性剂的离散单元递送给患者的方法。 具有第一和第二端的细长管状构件包括第一和第二流动路径。 所述流路中的任一个或两者包含活性剂。 液体被吸入构件的第一端，液体和活性剂被从构件的第二端引出并进入患者的口中。
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