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公开(公告)号：US09029503B2
公开(公告)日：2015-05-12
申请号：US13504054
申请日：2010-10-28
申请人： Oleg Melnyk , Reda Mhidia , Julien Dheur , Nathalie Ollivier
发明人： Oleg Melnyk , Reda Mhidia , Julien Dheur , Nathalie Ollivier
CPC分类号： C07K1/026
摘要： The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X″—X2 (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2 (I) and a polypeptide of formula: H—X″—X2. (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
摘要翻译： 本发明主要涉及一种制备下式多肽的方法：X1-X“-X2（Ⅲ）X1和X2各自表示肽片段，X”表示包含巯基官能团的氨基酸残基，所述方法至少包括 式X1-N（CH2CH2SH）2（I）的多肽与式H-X“-X2的多肽之间的连接反应的一步。 （II）本发明还涉及式（I）本身的多肽及其获得方法以及适于获得它们的树脂载体。
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2.发明申请公开(公告)号：US20130331545A1
公开(公告)日：2013-12-12
申请号：US13985369
申请日：2012-02-15
申请人： Oleg Melnyk , Nathalie Ollivier , Reda Mhidia , Julien Dheur
发明人： Oleg Melnyk , Nathalie Ollivier , Reda Mhidia , Julien Dheur
IPC分类号： C07K1/02
摘要： Method for preparing a peptide assembly of n fragments and n−1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci−1-Ai- . . . -Cn−1-An (I) in which A1, A2, A3, . . . Ai . . . An are peptide fragments, C1, C2, C3 . . . Ci−1 . . . Cn−1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
摘要翻译： 制备具有硫醇官能团的n个片段和n-1个氨基酸的肽组合物的方法，由式A1-C1-A2-C2-A3-表示。 。 。 -Ci-1-Ai-。 。 。 -Cn-1-An（I）其中A1，A2，A3，...。 。 。 艾。 。 。 An是肽片段，C1，C2，C3。 。 。 Ci-1。 。 。 Cn-1是具有硫醇官能团的氨基酸残基，n为3至50，i为2至n，其中肽 - 硫酯制备如下：A1-SR（II），其中A1为肽 片段，SR是烷基硫酯残基，R是任选取代的烷基，起始于双（2-磺基乙基）氨基肽。
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公开(公告)号：US10072041B2
公开(公告)日：2018-09-11
申请号：US13985369
申请日：2012-02-15
申请人： Oleg Melnyk , Nathalie Ollivier , Reda Mhidia , Julien Dheur
发明人： Oleg Melnyk , Nathalie Ollivier , Reda Mhidia , Julien Dheur
摘要： Method for preparing a peptide assembly of n fragments and n−1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci−1-Ai- . . . -Cn−1-An (I) in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci−1 . . . Cn−1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
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公开(公告)号：US20120220721A1
公开(公告)日：2012-08-30
申请号：US13504054
申请日：2010-10-28
申请人： Oleg Melnyk , Reda Mhidia , Julien Dheur , Nathalie Ollivier
发明人： Oleg Melnyk , Reda Mhidia , Julien Dheur , Nathalie Ollivier
CPC分类号： C07K1/026
摘要： The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X″—X2 (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2 (I) and a polypeptide of formula: H—X″—X2. (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
摘要翻译： 本发明主要涉及一种制备下式多肽的方法：X1-X“-X2（Ⅲ）X1和X2各自表示肽片段，X”表示包含巯基官能团的氨基酸残基，所述方法至少包括 式X1-N（CH2CH2SH）2（I）的多肽与式H-X“-X2的多肽之间的连接反应的一步。 （II）本发明还涉及式（I）本身的多肽及其获得方法以及适于获得它们的树脂载体。
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