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1.发明公开公开(公告)号：US20240279202A1
公开(公告)日：2024-08-22
申请号：US18289513
申请日：2022-05-03
Applicant: NURIX THERAPEUTICS, INC.
Inventor： Joel MCINTOSH , Daisuke KATO , Jeffrey MIHALIC , Ge PENG
IPC: C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/513 , C07D471/10
CPC classification number: C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/513 , C07D471/10
Abstract: Provided herein are compounds for inhibiting and/or degrading IL-2 inducible T-cell kinase (ITK), compositions comprising the compounds, methods of making the same, and methods of their use for treating diseases or disorders including cancer, inflammatory, and autoimmune diseases.
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2.发明公开公开(公告)号：US20240018162A1
公开(公告)日：2024-01-18
申请号：US18054118
申请日：2022-11-09
Applicant: Nurix Therapeutics, Inc. , Gilead Sciences, Inc.
Inventor： John Buell , Frederick Cohen , Ryan Pemberton , Hunter P. Shunatona , Lan Wang , Mark Edward Zak
IPC: C07D519/00
CPC classification number: C07D519/00
Abstract: The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by HPK1.
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公开(公告)号：US11820781B2
公开(公告)日：2023-11-21
申请号：US17111454
申请日：2020-12-03
Applicant: Nurix Therapeutics, Inc.
Inventor： Aileen Kelly , Arthur T. Sands
IPC: A61P35/00 , A61P19/00 , A61P37/00 , C07D487/10 , C07D498/10 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
CPC classification number: C07D498/10 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107
Abstract: This disclosure relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The description also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20230212186A1
公开(公告)日：2023-07-06
申请号：US18068195
申请日：2022-12-19
Applicant: Nurix Therapeutics, Inc.
Inventor： Arthur T. SANDS , Neil F. BENCE , Christoph W. ZAPF , Frederick COHEN , Chenbo WANG , Thomas CUMMINS , Hiroko TANAKA , Hunter SHUNATONA , Mario CARDOZO , Dahlia WEISS , Jennifa GOSLING
IPC: C07D403/12 , C07D403/14 , C07D413/14 , C07D401/14 , C07D405/14 , C07D491/08 , C07D471/04
CPC classification number: C07D403/12 , C07D403/14 , C07D413/14 , C07D401/14 , C07D405/14 , C07D491/08 , C07D471/04
Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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公开(公告)号：US20230029378A1
公开(公告)日：2023-01-26
申请号：US17876433
申请日：2022-07-28
Applicant: NURIX THERAPEUTICS, INC.
Inventor： Daniel W. ROBBINS , Arthur T. SANDS , Joel MCINTOSH , Jeffrey MIHALIC , Jeffrey WU , Daisuke KATO , Dahlia WEISS , Ge PENG
IPC: C07D487/10 , C07D413/14 , C07D471/10 , C07D498/10 , C07D487/04 , C07D417/14 , C07D491/107 , C07D401/14
Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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Patent Agency Ranking
公开(公告)号：US11530229B2
公开(公告)日：2022-12-20
申请号：US16875917
申请日：2020-05-15
Applicant: Nurix Therapeutics, Inc.
Inventor： Arthur T. Sands , Neil F. Bence , Christoph W. Zapf , Frederick Cohen , Chenbo Wang , Thomas Cummins , Hiroko Tanaka , Hunter Shunatona , Mario Cardozo , Dahlia Weiss , Jennifa Gosling
IPC: C07D498/08 , C07D403/12 , C07D403/14 , C07D413/14 , C07D471/04
Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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公开(公告)号：US11479556B1
公开(公告)日：2022-10-25
申请号：US15734774
申请日：2019-10-14
Applicant: NURIX THERAPEUTICS, INC.
Inventor： Daniel W. Robbins , Arthur T. Sands , Joel McIntosh , Jeffrey Mihalic , Jeffrey Wu , Daisuke Kato , Dahlia Weiss , Ge Peng
IPC: C07D487/10 , C07D401/14 , C07D471/10 , C07D417/14 , C07D413/14 , C07D491/107 , C07D498/10 , C07D487/04
Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20220143195A1
公开(公告)日：2022-05-12
申请号：US17430721
申请日：2020-02-04
Applicant: NURIX THERAPEUTICS, INC.
Inventor： Diasuke KATO , Zef KNOST , Jeffrey MIHALIC , Daniel W. ROBBINS , Arthur T. SANDS
Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US12091426B2
公开(公告)日：2024-09-17
申请号：US18054118
申请日：2022-11-09
Applicant: Nurix Therapeutics, Inc. , Gilead Sciences, Inc.
Inventor： John Buell , Frederick Cohen , Ryan Pemberton , Hunter P. Shunatona , Lan Wang , Mark Edward Zak
IPC: C07D519/00
CPC classification number: C07D519/00
Abstract: The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by HPK1.
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公开(公告)号：US20240293458A1
公开(公告)日：2024-09-05
申请号：US18443228
申请日：2024-02-15
Applicant: NURIX THERAPEUTICS, INC.
Inventor： Arthur T. SANDS , Neil F. Bence , Christoph W. Zapf , Frederick Cohen , Chenbo Wang , Thomas Cummins , Hiroko Tanaka , Hunter Shunatona , Mario Cardozo , Dahlia Weiss , Jennifa Gosling
IPC: A61K35/17 , A61K31/438 , A61K31/454 , A61K31/4545 , A61K33/243 , A61K35/761 , A61K35/763 , A61K35/768 , A61K38/19 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61N5/10 , A61P35/00 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/107 , C07F5/02 , C12N5/0783
CPC classification number: A61K35/17 , A61K31/438 , A61K31/454 , A61K31/4545 , A61K33/243 , A61K35/761 , A61K35/763 , A61K35/768 , A61K38/193 , A61K39/0011 , A61K39/39 , A61K39/3955 , A61K45/06 , A61N5/1001 , A61N5/1077 , A61P35/00 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/107 , C07F5/022 , C12N5/0636 , A61K2039/5152 , C12N2501/2302 , C12N2501/998 , C12N2501/999
Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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