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公开(公告)号：US20090012107A1
公开(公告)日：2009-01-08
申请号：US12013640
申请日：2008-01-14
Applicant: Mohammad Javad Aman , Sina Bavari , James C. Burnett , Kelly Lyn Warfield
Inventor： Mohammad Javad Aman , Sina Bavari , James C. Burnett , Kelly Lyn Warfield
IPC: A61K31/506 , C12N5/00 , A61K31/381 , A61K31/343 , A61K31/4184 , A61K31/416 , A61P31/12 , A61K31/122 , A61K31/404 , A61K31/42 , A61K31/4178 , A61K31/4745
CPC classification number: A61K31/505 , A61K31/12 , A61K31/16 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/421 , A61K31/4745 , A61K31/506
Abstract: Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Poxviridae. Thus, methods of preventing, inhibiting, or reducing the viral activity of various viruses are provided as well as methods of treating viral infections.
Abstract translation: 本文公开了对属于不同家族的多种病毒如博拉维病毒，非螺病毒属，副粘病毒科，弹状病毒科，沙病毒科，布尼亚病毒科，正粘病毒科和痘病毒科的抗病毒活性的化合物。 因此，提供了预防，抑制或降低各种病毒的病毒活性的方法以及治疗病毒感染的方法。
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公开(公告)号：US20170183396A1
公开(公告)日：2017-06-29
申请号：US15120245
申请日：2015-02-19
Applicant: Jody BERRY , Grant MCCLARTY , Kelly WARFIELD , Mohammad Javad AMAN
Inventor： Jody BERRY , Grant MCCLARTY , Kelly WARFIELD , Mohammad Javad AMAN
IPC: C07K16/10 , G01N33/569
CPC classification number: C07K16/10 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/56983 , G01N2333/08
Abstract: The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.
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Patent Agency Ranking
公开(公告)号：US20120035198A1
公开(公告)日：2012-02-09
申请号：US13179267
申请日：2011-07-08
Applicant: Mohammad Javad Aman , Sina Bavari , James C. Burnett , Kelly Lyn Warfield
Inventor： Mohammad Javad Aman , Sina Bavari , James C. Burnett , Kelly Lyn Warfield
IPC: A61K31/506 , A61K31/4184 , A61K31/343 , A61K31/165 , A61K31/381 , A61P31/16 , A61K31/421 , A61K31/4178 , A61K31/4375 , A61P31/12 , A61P31/14 , A61P31/20 , C12N7/06 , A61K31/404
CPC classification number: A61K31/505 , A61K31/12 , A61K31/16 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/421 , A61K31/4745 , A61K31/506
Abstract: Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Poxviridae. Thus, methods of preventing, inhibiting, or reducing the viral activity of various viruses are provided as well as methods of treating viral infections.
Abstract translation: 本文公开了对属于不同家族的多种病毒如博拉维病毒，非螺病毒属，副粘病毒科，弹状病毒科，沙病毒科，布尼亚病毒科，正粘病毒科和痘病毒科的抗病毒活性的化合物。 因此，提供了预防，抑制或降低各种病毒的病毒活性的方法以及治疗病毒感染的方法。
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公开(公告)号：US07999001B2
公开(公告)日：2011-08-16
申请号：US12013640
申请日：2008-01-14
Applicant: Mohammad Javad Aman , Sina Bavari , James C. Burnett , Kelly Lyn Warfield
Inventor： Mohammad Javad Aman , Sina Bavari , James C. Burnett , Kelly Lyn Warfield
IPC: A01N43/12 , A61K31/38 , C07D333/00 , C07D495/00
CPC classification number: A61K31/505 , A61K31/12 , A61K31/16 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/421 , A61K31/4745 , A61K31/506
Abstract: Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Poxviridae. Thus, methods of preventing, inhibiting, or reducing the viral activity of various viruses are provided as well as methods of treating viral infections.
Abstract translation: 本文公开了对属于不同家族的多种病毒如博拉维病毒，非螺病毒属，副粘病毒科，弹状病毒科，沙病毒科，布尼亚病毒科，正粘病毒科和痘病毒科的抗病毒活性的化合物。 因此，提供了预防，抑制或降低各种病毒的病毒活性的方法以及治疗病毒感染的方法。
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公开(公告)号：US09109036B2
公开(公告)日：2015-08-18
申请号：US13984226
申请日：2012-02-06
Applicant: Mohammad Javad Aman , Rajan Prasad Adhikari , Hatice Karauzum , Kelly Lyn Warfield , Tam Luong Nguyen
Inventor： Mohammad Javad Aman , Rajan Prasad Adhikari , Hatice Karauzum , Kelly Lyn Warfield , Tam Luong Nguyen
IPC: A61K39/085 , C07K14/31 , C07K16/12 , A61K38/00
CPC classification number: C07K14/31 , A61K38/00 , A61K39/085 , A61K39/39 , A61K2039/505 , A61K2039/55505 , A61K2039/55572 , C07K16/1271 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/24 , C07K2319/33 , C07K2319/40 , C07K2319/43 , C07K2319/60
Abstract: The present invention provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present invention provides methods of inducing an immune response against an alpha-hemolysin-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.
Abstract translation: 本发明提供了可用于预防和治疗金黄色葡萄球菌感染的免疫原性组合物。 特别地，本发明提供诱导针对表达α-溶血素的金黄色葡萄球菌的免疫应答，预防或治疗金黄色葡萄球菌感染的方法，以及用于预防或治疗金黄色葡萄球菌感染的组合物的方法。
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公开(公告)号：US20140286960A1
公开(公告)日：2014-09-25
申请号：US14235315
申请日：2012-07-27
Applicant: Jody Berry , Laura Saward , Robyn Cassan , Xiaobing Han , Mohammad Javad Aman , Rajan P. Adhikari , Hatice Karauzum
Inventor： Jody Berry , Laura Saward , Robyn Cassan , Xiaobing Han , Mohammad Javad Aman , Rajan P. Adhikari , Hatice Karauzum
CPC classification number: A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1271 , C07K16/1275 , C07K2317/30 , C07K2317/76 , C07K2317/92
Abstract: Compositions and methods for the treatment or prevention of Staphyloccus aureus infection in a subject are provided. Antibody compositions comprising monoclonal antibodies to alpha-hemolysin protein are also provided. The methods provide administering a composition to the subject in an amount effective to reduce or eliminate or prevent relapse S. aureus bacterial infection and/or induce an immune response to Staphylococcus aureus alpha-hemolysin.
Abstract translation: 提供用于治疗或预防受试者中金黄色葡萄球菌感染的组合物和方法。 还提供了包含对α-溶血素蛋白的单克隆抗体的抗体组合物。 所述方法提供以有效减少或消除或预防金黄色葡萄球菌细菌感染和/或诱导对金黄色葡萄球菌α-溶血素的免疫应答的量向受试者施用组合物。
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公开(公告)号：US20140079709A1
公开(公告)日：2014-03-20
申请号：US13984226
申请日：2012-02-06
Applicant: Mohammad Javad Aman , Rajan Prasad Adhikari , Hatice Karauzum , Kelly Lyn Warfield , Tam Luong Nguyen
Inventor： Mohammad Javad Aman , Rajan Prasad Adhikari , Hatice Karauzum , Kelly Lyn Warfield , Tam Luong Nguyen
CPC classification number: C07K14/31 , A61K38/00 , A61K39/085 , A61K39/39 , A61K2039/505 , A61K2039/55505 , A61K2039/55572 , C07K16/1271 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/24 , C07K2319/33 , C07K2319/40 , C07K2319/43 , C07K2319/60
Abstract: The present invention provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present invention provides methods of inducing an immune response against an alpha-hemolysin-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.
Abstract translation: 本发明提供了可用于预防和治疗金黄色葡萄球菌感染的免疫原性组合物。 特别地，本发明提供诱导针对表达α-溶血素的金黄色葡萄球菌的免疫应答，预防或治疗金黄色葡萄球菌感染的方法，以及用于预防或治疗金黄色葡萄球菌感染的组合物的方法。
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