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1.发明授权Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy 有权具有抗菌活性并具有改善的体内功效的取代的哌啶子基苯基恶唑烷酮公开(公告)号：US08729269B2
公开(公告)日：2014-05-20
申请号：US12705258
申请日：2010-02-12
申请人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
发明人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
IPC分类号： C07D411/06 , A61K31/454
CPC分类号： C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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2.发明授权Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy 失效具有抗菌活性并具有改善的体内功效的取代的哌啶子基苯基恶唑烷酮公开(公告)号：US07687627B2
公开(公告)日：2010-03-30
申请号：US10935708
申请日：2004-09-07
申请人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
发明人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
IPC分类号： C07D491/113 , A61K31/438
CPC分类号： C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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3.发明授权Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效产生三重靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途公开(公告)号：US07626032B2
公开(公告)日：2009-12-01
申请号：US12150075
申请日：2008-04-24
申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
IPC分类号： C07D211/56
CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859
摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.
摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。
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4.发明授权Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效产生三重靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途公开(公告)号：US07393957B2
公开(公告)日：2008-07-01
申请号：US10945504
申请日：2004-09-20
申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859
摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.
摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。
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5.发明申请SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICROBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY 有权具有改善活体功效的抗微生物活性的替代哌啶苯并噻唑啉酮公开(公告)号：US20100144735A1
公开(公告)日：2010-06-10
申请号：US12705258
申请日：2010-02-12
申请人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugil , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
发明人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugil , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/438 , A61K31/4545 , A61K31/454 , C07D498/10 , C07D495/10 , C07D491/113 , C07D413/10 , A61P31/04 , C07D491/107 , C07D413/14 , C07D513/10
CPC分类号： C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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6.发明申请New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效新一代三靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途公开(公告)号：US20080214608A1
公开(公告)日：2008-09-04
申请号：US12150075
申请日：2008-04-24
申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859
摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.
摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。
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公开(公告)号：US07098219B2
公开(公告)日：2006-08-29
申请号：US09919347
申请日：2001-07-31
申请人： Noel John de Souza , Mahesh Vithalbhai Patel , Shrikant V Gupte , Dilip J Upadhyay , Milind Chintaman Shukla , Nishith C Chaturvedi , Satish B Bhawsar , Sheela Chandresekharan Nair , Mohammed A Jafri , Habil Fakhruddin Khorakiwala
发明人： Noel John de Souza , Mahesh Vithalbhai Patel , Shrikant V Gupte , Dilip J Upadhyay , Milind Chintaman Shukla , Nishith C Chaturvedi , Satish B Bhawsar , Sheela Chandresekharan Nair , Mohammed A Jafri , Habil Fakhruddin Khorakiwala
IPC分类号： C07D471/04 , C07D471/02 , A61K31/44 , A61K31/47
CPC分类号： C07D215/233 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08
摘要： Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.
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8.发明授权Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效产生三重靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途公开(公告)号：US06964966B2
公开(公告)日：2005-11-15
申请号：US10128996
申请日：2002-04-23
申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Shrikant V. Gupte , Dilip J. Upadhyay , Satish B. Bhawsar , Rupinder K. Beri , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Milind Chintaman Shukla , Yati Chugh , Nitin Shetty , Ravindra D. Yeole , M. Madhav Reddy
发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Shrikant V. Gupte , Dilip J. Upadhyay , Satish B. Bhawsar , Rupinder K. Beri , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Milind Chintaman Shukla , Yati Chugh , Nitin Shetty , Ravindra D. Yeole , M. Madhav Reddy
IPC分类号： A61K31/095 , A61K31/191 , A61K31/47 , A61K31/4709 , A61K45/06 , A61P3/04 , A61P11/00 , A61P13/10 , A61P13/12 , A61P19/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , C07D215/22 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , C07D519/00 , A61K31/497 , C07D215/36 , C07D279/12 , C07D401/00 , C07F5/02
CPC分类号： C07D215/233 , A61K31/47 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08
摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.
摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。
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公开(公告)号：US06878713B2
公开(公告)日：2005-04-12
申请号：US10318367
申请日：2002-12-12
申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla
IPC分类号： A61K31/47 , A61K45/06 , C07D215/22 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , C07D519/00 , A61K31/497 , A61K31/44 , C07D215/16 , C07D455/06
CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859
摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.
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