公开(公告)号：US08178135B2

公开(公告)日：2012-05-15

申请号：US12281940

申请日：2007-03-05

Applicant: Kazuo Umezawa ,  Mikio Fujii

Inventor： Kazuo Umezawa ,  Mikio Fujii

IPC: A61K36/00

CPC classification number: A61K36/24 ,  A23L33/105 ,  A61K31/475 ,  C07D491/22

Abstract: PROBLEMS TO BE SOLVED BY THE INVENTIONTo provide aqueous solutions of conophylline and/or conophyllidine; methods for purifying conophylline and/or conophyllidine from the aqueous solutions; methods for producing the aqueous solutions, water-soluble compositions containing conophylline and/or a conophyllidine useful for food compositions or pharmaceutical compositions or methods for preparing the same; as well as food compositions or pharmaceutical compositions containing the water-soluble compositions.MEANS OF SOLVING THE PROBLEMSIt has been found that conophylline and/or conophyllidine can be efficiently extracted from a plant producing conophylline and/or conophyllidine with an acidic aqueous solution having a pH equal to or less than 4. The extract thus obtained, i.e., aqueous solution of conophylline, and/or conophyllidine is useful for production of, for instance, food compositions, pharmaceutical compositions, etc.

Abstract translation: 本发明要解决的问题提供茶碱和/或叶绿素碱的水溶液; 从水溶液中纯化茶碱和/或叶绿素的方法; 制备水溶液的方法，含有可用于食品组合物或药物组合物的茶碱和/或叶绿素的水溶性组合物或其制备方法; 以及含有水溶性组合物的食品组合物或药物组合物。 解决问题的手段已经发现，可以用pH等于或小于4的酸性水溶液从产生茶碱和/或叶绿素的植物中有效地提取茶碱和/或叶肉氨酸。由此得到的提取物， 茶碱水溶液和/或叶绿素碱可用于生产例如食品组合物，药物组合物等。

公开(公告)号：US20050213107A1

公开(公告)日：2005-09-29

申请号：US11054441

申请日：2005-02-10

Applicant: Kouichi Ichimura ,  Kenji Ohkuma ,  Mikio Fujii ,  Hayato Goto ,  Kentaro Torii

Inventor： Kouichi Ichimura ,  Kenji Ohkuma ,  Mikio Fujii ,  Hayato Goto ,  Kentaro Torii

IPC: G01B9/02 ,  G02B21/00

CPC classification number: G01Q60/00 ,  G01Q20/02 ,  G02B21/00

Abstract: A microscope includes a photon source which sequentially generates sets of quantum-mechanically entangled photons including at least two photons, a lens which focuses a set of photons, an actuator which varies a relative distance between a focal position of the lens and a specimen with a minute displacement, a detector detecting photons transmitted through or scattered by the specimen, and a counter counting coincidence detections of n-numbers of photons with the detector during a gating time which is set so that a rate that a number of photons detected during thereof belong to a single set of quantum-mechanically entangled photons exceeds a predetermined rate depending on the varied relative distance.

Abstract translation: 显微镜包括光子源，其顺序地产生包括至少两个光子的量子机械纠缠光子的集合，聚焦一组光子的透镜，致动器，其改变透镜的焦点位置与样品之间的相对距离， 检测器检测由样本透射或散射的光子，以及在选通时间期间对与检测器相关的n个光子的一致性检测的计数器，其被设置为使得在其期间检测到的光子的数量属于 根据变化的相对距离，单个量子机械纠缠的光子超过预定速率。

公开(公告)号：US06587076B2

公开(公告)日：2003-07-01

申请号：US10026869

申请日：2001-12-20

Applicant: Mikio Fujii ,  Takeshi Takenoshita

Inventor： Mikio Fujii ,  Takeshi Takenoshita

IPC: H01Q326

CPC classification number: H01Q3/44

Abstract: A beam scanning antenna has the following structure: A primary radiator and a flat wave collector are disposed between metal plates, and input and output portions are provided on one of the metal plates. In the wave collector, a plurality of strip-shaped electrodes substantially parallel to one another in the direction of travel of electromagnetic waves is disposed on one principal surface of a substrate made of a material whose dielectric constant can be changed by an electrostatic field, and on the other principal surface, an counter electrode being strip-shaped or formed on a substantially entire area of the surface is disposed so as to be opposed to the strip-shaped electrodes.

公开(公告)号：US06303360B1

公开(公告)日：2001-10-16

申请号：US09543446

申请日：2000-04-05

Applicant: Alexander Blinkovsky ,  Tony S. Byun ,  Alan V. Klotz ,  Alan Sloma ,  Kimberly Brown ,  Maria Tang ,  Mikio Fujii ,  Chigusa Marumoto ,  Lene Venke Kofod

Inventor： Alexander Blinkovsky ,  Tony S. Byun ,  Alan V. Klotz ,  Alan Sloma ,  Kimberly Brown ,  Maria Tang ,  Mikio Fujii ,  Chigusa Marumoto ,  Lene Venke Kofod

IPC: C12N948

CPC classification number: A23J3/34 ,  C12N9/48 ,  C12P21/06

Abstract: The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.

Abstract translation: 本发明涉及具有氨基肽酶活性的分离的多肽和分离的编码多肽的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US5510366A

公开(公告)日：1996-04-23

申请号：US330670

申请日：1994-10-28

Applicant: Yoshinori Kyotani ,  Katsumi Kawamine ,  Tsutomu Toma ,  Tadaaki Ohgiya ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Tomio Ohta ,  Toshiaki Oda ,  Yukihiro Okuno ,  Kimiyuki Shibuya ,  Yoshio Takahashi ,  Mikio Fujii ,  Yasumi Uchida

Inventor： Yoshinori Kyotani ,  Katsumi Kawamine ,  Tsutomu Toma ,  Tadaaki Ohgiya ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Tomio Ohta ,  Toshiaki Oda ,  Yukihiro Okuno ,  Kimiyuki Shibuya ,  Yoshio Takahashi ,  Mikio Fujii ,  Yasumi Uchida

IPC: C07D491/04 ,  C07D491/048 ,  A61K31/40 ,  C07D491/056

CPC classification number: C07D491/04

Abstract: An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

Abstract translation: 由式（1）表示的吲哚衍生物，本文R10为氢或低级烷基，虚线可以任选存在，R 1 -R 9表示各种取代基。 化合物（1）对心肌呈现正性肌力作用，抗心律失常作用和血管舒张作用而不增加心率。 包含该化合物作为有效成分的心脏治疗剂对于治疗心力衰竭和心律失常是非常有效的。

公开(公告)号：US5158891A

公开(公告)日：1992-10-27

申请号：US492227

申请日：1990-03-13

Applicant: Yasuhiko Takeda ,  Mikio Fujii ,  Yukihiro Nakajo ,  Sadao Isshiki

Inventor： Yasuhiko Takeda ,  Mikio Fujii ,  Yukihiro Nakajo ,  Sadao Isshiki

IPC: C12N15/00 ,  C12N15/77

CPC classification number: C12N15/77 ,  Y10S435/843

Abstract: A plasmid and a DNA fragment each of which contains a gene for tetracycline resistance derived from a glutamic acid-producing coryneform bacterium, and a coryneform bacterium containing said DNA fragment. The gene for tetracycline resistance derived from a glutamic acid-producing coryneform bacterium is a useful selective marker in effecting the breeding of a glutamic acid-producing coryneform bacterium by genetic recombination. Using the plasmid, the DNA fragment or the coryneform bacterium of the present invention, breeding of the glutamic acid-producing coryneform bacterium can be easily and effectively conducted by means of recombinant DNA technique.

Abstract translation: 一种质粒和一个DNA片段，每个含有产生谷氨酸的棒状细菌的四环素抗性基因，以及含有所述DNA片段的棒状细菌。 来自产生谷氨酸棒状杆菌的四环素抗性的基因是通过遗传重组实现产生谷氨酸的棒状细菌的育种的有用选择标记。 使用质粒，可以通过重组DNA技术容易且有效地进行本发明的DNA片段或棒状细菌的育种，产生谷氨酸的棒状细菌。

公开(公告)号：US20130224252A1

公开(公告)日：2013-08-29

申请号：US13819262

申请日：2011-05-26

Applicant: Takashi Hara ,  Yuki Higuchi ,  Mikio Fujii

Inventor： Takashi Hara ,  Yuki Higuchi ,  Mikio Fujii

IPC: A61K35/74 ,  A23L1/30

CPC classification number: A61K35/747 ,  A23L33/135

Abstract: The purpose of the present invention is to provide a better intestine immunomodulator. The intestine immunomodulator of the present invention comprises bacterial cells or a bacterial component of a Lactobacillus paracasei K71 strain having an international deposit No.: FERM BP-11098 as an active ingredient. Preferably, the intestine immunomodulator is used to facilitate production of secretory immunoglobulin A or to activate natural killer cells.

Abstract translation: 本发明的目的是提供一种更好的肠免疫调节剂。 本发明的肠内免疫调节剂包含具有国际保藏号：FERM BP-11098的细菌细胞或副干酪乳杆菌K71菌株的细菌成分作为活性成分。 优选地，肠免疫调节剂用于促进分泌型免疫球蛋白A的产生或激活天然杀伤细胞。

公开(公告)号：US08171556B2

公开(公告)日：2012-05-01

申请号：US10398743

申请日：2001-10-10

Applicant: Masamichi Torigai ,  Mikio Fujii ,  Yutaka Tsukamoto

Inventor： Masamichi Torigai ,  Mikio Fujii ,  Yutaka Tsukamoto

IPC: H04L29/06

CPC classification number: G06Q30/02 ,  G06Q20/12 ,  G06Q20/3821 ,  G06Q20/383 ,  G06Q20/385 ,  G06Q20/40 ,  G06Q30/06 ,  G06Q30/0601 ,  G06Q30/0609

Abstract: A prescribed virtual person was created for allowing a real person (user) in the actual world to pretend to be the virtual person (virtual person) and act as the virtual person when acting on a network and registered in a database 12a of a financial institution 7 for enabling the user to make shopping or the like as the virtual person with an electronic certificate issued by the financial institution 7 for the virtual person when pretending to be the virtual person and acting on the network, and the address of the virtual person necessary as the destination of a purchased article was set to a nearby convenience store. When acting on the network as the virtual person, cookies are rendered easily acceptable as compared with the case of the real person.

Abstract translation: 创建了一个规定的虚拟人物，用于允许实际世界中的真人（用户）伪装成虚拟人（虚拟人），并且在作为网络并在金融机构的数据库12a中注册时作为虚拟人 7，用于使用户作为虚拟人物的虚拟人物作为虚拟人，假设虚拟人并且在网络上行动时，由金融机构7为虚拟人发行的电子证书，以及虚拟人的地址 因为购买的文章的目的地被设置到附近的便利店。 当作为虚拟人员在网络上行事时，与真实人物相比，cookie变得容易被接受。

公开(公告)号：US20100063929A1

公开(公告)日：2010-03-11

申请号：US12613757

申请日：2009-11-06

Applicant: Masamichi Torigai ,  Mikio Fujii ,  Yutaka Tsukamoto

Inventor： Masamichi Torigai ,  Mikio Fujii ,  Yutaka Tsukamoto

IPC: G06Q20/00 ,  G06Q40/00 ,  H04L9/00 ,  G06F17/00

CPC classification number: G06Q30/02 ,  G06Q20/12 ,  G06Q20/3821 ,  G06Q20/383 ,  G06Q20/385 ,  G06Q20/40 ,  G06Q30/06 ,  G06Q30/0601 ,  G06Q30/0609

Abstract: A prescribed virtual person was created for allowing a real person (user) in the actual world to pretend to be the virtual person (virtual person) and act as the virtual person when acting on a network and registered in a database 12a of a financial institution 7 for enabling the user to make shopping or the like as the virtual person with an electronic certificate issued by the financial institution 7 for the virtual person when pretending to be the virtual person and acting on the network, and the address of the virtual person necessary as the destination of a purchased article was set to a nearby convenience store. When acting on the network as the virtual person, cookies are rendered easily acceptable as compared with the case of the real person.

Abstract translation: 创建了一个规定的虚拟人物，用于允许实际世界中的真人（用户）伪装成虚拟人（虚拟人），并且在作为网络并在金融机构的数据库12a中注册时作为虚拟人 7，用于使用户作为虚拟人物的虚拟人物作为虚拟人，假设虚拟人并且在网络上行动时，由金融机构7为虚拟人发行的电子证书，以及虚拟人的地址 因为购买的文章的目的地被设置到附近的便利店。 当作为虚拟人员在网络上行事时，与真实人物相比，cookie变得容易被接受。

公开(公告)号：US20060088157A1

公开(公告)日：2006-04-27

申请号：US11254719

申请日：2005-10-21

Applicant: Mikio Fujii

Inventor： Mikio Fujii

IPC: H04L9/30

CPC classification number: H04L9/3006 ,  H04L9/0858 ,  H04L9/3226

Abstract: According to an aspect of this invention, there is provided a public key encryption apparatus comprising a device generating a single photon, a device generating a random number, a storage device storing the random number as a private key, a device which transmits a single photon encoded by the private key composed of a basis set identifying value section and a bit value section, a device receiving the single photon, a device creating message information and an authenticator, a device encrypting the quantum state of the received single photon on the basis of the message information and authenticator and transmitting the single photon, a device decrypting the message information and authenticator from the received single photon according to the private key, and a device which invalidates the message information if the authenticator calculated from the decrypted message information is inconsistent with the decrypted authenticator.

Abstract translation: 根据本发明的一个方面，提供一种包括产生单个光子的装置，产生随机数的装置，存储随机数作为私钥的存储装置的公开密钥加密装置，发送单个光子的装置 由基准集合识别值部分和比特值部分组成的专用密钥编码，接收单个光子的装置，创建消息信息和认证器的装置，基于所接收的单个光子加密所接收的单个光子的量子态的装置 消息信息和认证器，并且发送单个光子，根据私钥从接收的单个光子解密消息信息和认证器的设备，以及如果从解密的消息信息计算出的认证符与消息信息不一致的设备使消息信息无效 解密的验证器。