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公开(公告)号：US20100137189A1
公开(公告)日：2010-06-03
申请号：US12452075
申请日：2008-06-26
CPC分类号： C07K14/805 , A61K38/00 , A61K47/60 , A61K47/62 , A61K47/6445
摘要： The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids. The invention provides such proteins that comprise a modification to enhance this pathway.
摘要翻译： 本发明涉及一种修饰的卟啉基携氧蛋白，如血红蛋白，已发现其未修饰状态具有低的电子转移亲和力位点和还原剂与铁氧体铁之间的高亲和力电子转移 通过一种或多种蛋白质氨基酸。 本发明提供了包含增强该途径的修饰的蛋白质。
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公开(公告)号：US20180235780A1
公开(公告)日：2018-08-23
申请号：US15751837
申请日：2016-08-10
CPC分类号： A61F2/6607 , A61F2/5044 , A61F2/66 , A61F2002/5001 , A61F2002/5009 , A61F2002/5067 , A61F2002/507 , A61F2002/5086 , A61F2002/5096 , A61F2002/6642 , A61F2002/665 , A61F2002/6657 , A61L27/306 , B29C65/70 , B29L2031/7532
摘要： A prosthetic foot, including a keel having a longitudinal axis. The keel includes a keel body including a heel portion, a forefoot portion, and an ankle portion positioned between the heel portion and the forefoot portion. The ankle portion includes a housing having a vertically oriented central axis. In addition, the prosthetic foot includes a coupling assembly disposed within the housing of the ankle portion. The coupling assembly includes a bearing member disposed about the central axis, a support sleeve concentrically disposed about the bearing member, and an embedding member disposed about the support sleeve. The embedding member includes a plurality of interlocking rings.
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公开(公告)号：US20180148125A1
公开(公告)日：2018-05-31
申请号：US15828400
申请日：2017-11-30
摘要： A pedal operated vehicle includes a frame and a drive wheel rotatably coupled to the frame. In addition, the vehicle includes a pedal assembly coupled to the frame and including a pedal sprocket. Further, the vehicle includes a transmission mounted to the frame. The transmission includes an input sprocket mounted to a rotatable first shaft and an output sprocket mounted to a rotatable second shaft. A first chain is disposed about the pedal sprocket and the input sprocket. The output sprocket is configured to drive the rotation of the drive wheel. Moreover, the transmission includes a first plurality of sprockets coupled to the rotatable first shaft and a second plurality of sprockets coupled to the rotatable second shaft. A second chain disposed about one sprocket of the first plurality of sprockets and one sprocket of the second plurality of sprockets.
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公开(公告)号：US6086807A
公开(公告)日：2000-07-11
申请号：US72303
申请日：1998-05-04
CPC分类号： B29C33/405 , B01F11/0082 , B01F11/0091 , B01F13/0033 , B01F15/00506 , B01F3/1221 , B29C33/3857 , B29C39/26 , Y10S425/044
摘要： A molding apparatus for forming a molded piece that includes a positive impression of an object, the molded piece comprising a monolithic block that is larger than the object. The apparatus comprises a container in which a negative impression of the object is formed by casting it in a fast-setting flowable compound, and a mold extension that snaps on to the container and provides an additional mold volume that is contiguous with the negative impression. The invention further comprises a mixing apparatus for mixing fast-setting compounds. In one embodiment, the mixing apparatus comprises a cylindrical jar with a screw-on lid. A rod passes through an aperture in the lid and moves axially with respect to the jar. The end of the rod external to the jar is configured as a handle, and the end of the rod internal to the jar is connected to a circular mesh. The circular mesh is oriented parallel to the bottom of the jar and has an outer diameter which is slightly less than the smallest inner diameter of the jar. Mixing is accomplished by repeatedly moving the mesh axially from the lid to the bottom of the jar and back again. The mesh cross-members have a cross-section which acts to break up clumps as they form, and the holes passing through the mesh have a constriction which advantageously adds turbulence to the mixture, enhancing the mixing efficiency of the mesh.
摘要翻译： 一种用于形成包括物体的正印模的模制件的模制装置，所述模制件包括大于所述物体的整体块。 该装置包括容器，在该容器中，通过将其放置在快速凝固的可流动化合物中而形成物体的负压印，以及模具延伸部，其卡扣到容器上并提供与负压印物邻接的附加模具体积。 本发明还包括用于混合快速凝固化合物的混合装置。 在一个实施例中，混合装置包括具有螺旋盖的圆柱形罐。 棒穿过盖中的孔并相对于罐轴向移动。 瓶子外部的杆的端部被配置为手柄，并且罐内部的杆的端部连接到圆形网。 圆形网格平行于罐子的底部定向，其外径略小于罐子的最小内径。 混合是通过将网格从盖子轴向反复移动到罐的底部并再次返回来实现的。 网状横梁具有横截面，其作用是在它们形成时破坏团块，并且通过网孔的孔具有有利地向混合物添加湍流的收缩，从而提高网的混合效率。
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公开(公告)号：US10857007B2
公开(公告)日：2020-12-08
申请号：US15751837
申请日：2016-08-10
摘要： A prosthetic foot, including a keel having a longitudinal axis. The keel includes a keel body including a heel portion, a forefoot portion, and an ankle portion positioned between the heel portion and the forefoot portion. The ankle portion includes a housing having a vertically oriented central axis. In addition, the prosthetic foot includes a coupling assembly disposed within the housing of the ankle portion. The coupling assembly includes a bearing member disposed about the central axis, a support sleeve concentrically disposed about the bearing member, and an embedding member disposed about the support sleeve. The embedding member includes a plurality of interlocking rings.
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公开(公告)号：US10569828B2
公开(公告)日：2020-02-25
申请号：US15828400
申请日：2017-11-30
摘要： A pedal operated vehicle includes a frame and a drive wheel rotatably coupled to the frame. In addition, the vehicle includes a pedal assembly coupled to the frame and including a pedal sprocket. Further, the vehicle includes a transmission mounted to the frame. The transmission includes an input sprocket mounted to a rotatable first shaft and an output sprocket mounted to a rotatable second shaft. A first chain is disposed about the pedal sprocket and the input sprocket. The output sprocket is configured to drive the rotation of the drive wheel. Moreover, the transmission includes a first plurality of sprockets coupled to the rotatable first shaft and a second plurality of sprockets coupled to the rotatable second shaft. A second chain disposed about one sprocket of the first plurality of sprockets and one sprocket of the second plurality of sprockets.
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公开(公告)号：US08609814B2
公开(公告)日：2013-12-17
申请号：US12452075
申请日：2008-06-26
IPC分类号： A61K35/14
CPC分类号： C07K14/805 , A61K38/00 , A61K47/60 , A61K47/62 , A61K47/6445
摘要： The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids. The invention provides such proteins that comprise a modification to enhance this pathway.
摘要翻译： 本发明涉及一种修饰的卟啉基携氧蛋白，如血红蛋白，已发现其未修饰状态具有低的电子转移亲和力位点和还原剂与铁氧体铁之间的高亲和力电子转移 通过一种或多种蛋白质氨基酸。 本发明提供了包含增强该途径的修饰的蛋白质。
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公开(公告)号：US20150073567A1
公开(公告)日：2015-03-12
申请号：US14483281
申请日：2014-09-11
CPC分类号： A61F2/60 , A61F2002/607
摘要： A pylon for a prosthetic device, the pylon having a central axis, a first end, and a second end. In an embodiment, the pylon includes a first connecting member disposed at the first end and configured to couple to a socket worn by an amputee. In addition, the pylon includes a second connecting member disposed at the second end and configured to couple to a prosthetic foot. Further, the pylon includes a pylon member extending axially from the first connecting member to the second connecting member, wherein the pylon member extends helically about the central axis.
摘要翻译： 一种用于假肢装置的挂架，所述挂架具有中心轴线，第一端部和第二端部。 在一个实施例中，挂架包括设置在第一端处并且被配置为耦合到由截肢者佩戴的插座的第一连接构件。 此外，所述托架包括设置在所述第二端处并且被配置为联接到假脚的第二连接构件。 此外，该塔架包括从第一连接构件轴向延伸到第二连接构件的塔架构件，其中塔架构件绕中心轴线螺旋地延伸。
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