公开(公告)号：US20180207503A1

公开(公告)日：2018-07-26

申请号：US15843966

申请日：2017-12-15

申请人： Michael Rivard

发明人： Michael Rivard

IPC分类号： A63B67/06 ,  A63F9/02

CPC分类号： A63B67/06 ,  A63B63/00 ,  A63B71/0672 ,  A63B2207/00 ,  A63F9/02 ,  A63F2011/0055

摘要： The present application describes a bag throwing game board and game. Players take a plurality of soft bags that are approximately round in shape and throw them from a distance towards the game board, which in various examples is in the shape of a tower, and has holes. Points are attributed to bags landing in different holes of the board, depending on the difficulty of landing the bag in each hole. After a series of throws, the point scores are totaled and the player earning the most points or the player first to reach a score goal wins.

公开(公告)号：US20070026392A1

公开(公告)日：2007-02-01

申请号：US11453003

申请日：2006-06-15

申请人： William Warren ,  Russell Higbee ,  Eric Mishkin ,  Guzman Sanchez-Schmitz ,  Heather Fahlenkamp ,  Michael Rivard

发明人： William Warren ,  Russell Higbee ,  Eric Mishkin ,  Guzman Sanchez-Schmitz ,  Heather Fahlenkamp ,  Michael Rivard

IPC分类号： C12Q1/70 ,  G01N33/567 ,  C12N5/08 ,  C12N5/06

CPC分类号： C12M21/08 ,  C12M25/14 ,  C12M35/08 ,  C12N5/0697 ,  C12N2501/21 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/11 ,  C12N2502/28 ,  C12N2502/30 ,  C12N2503/04 ,  C12N2531/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2535/10 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2800/24

摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.

摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括细胞培养物，其包含包含淋巴组织的三维基质，包含上皮和/或内皮细胞的三维基质和患病细胞。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药​​物，生物制剂和其它化学品的体外试验。

公开(公告)号：US09073957B2

公开(公告)日：2015-07-07

申请号：US13992404

申请日：2011-12-09

申请人： Angelo Paci ,  Thierry Martens ,  Michael Rivard ,  Patrick Couvreur ,  Didier Desmael ,  Joachim Caron

发明人： Angelo Paci ,  Thierry Martens ,  Michael Rivard ,  Patrick Couvreur ,  Didier Desmael ,  Joachim Caron

IPC分类号： C07F9/02 ,  A01N57/36 ,  A61K31/66 ,  C07F9/6584

CPC分类号： C07F9/65846 ,  A61K47/6851 ,  C07K16/30

摘要： The present invention relates to novel derivatives of oxazaphosphorines that are pre-activated, to the methods for preparing same, to the pharmaceutical compositions containing same and to the therapeutic use thereof, in particular for treating cancer.

摘要翻译： 本发明涉及预活化的恶唑烷的新衍生物，其制备方法，含有该衍生物的药物组合物及其治疗用途，特别是用于治疗癌症。

公开(公告)号：US20130261088A1

公开(公告)日：2013-10-03

申请号：US13992404

申请日：2011-12-09

申请人： Angelo Paci ,  Thierry Martens ,  Michael Rivard ,  Patrick Couvreur ,  Didier Desmael ,  Joachim Caron

发明人： Angelo Paci ,  Thierry Martens ,  Michael Rivard ,  Patrick Couvreur ,  Didier Desmael ,  Joachim Caron

IPC分类号： C07F9/6584

CPC分类号： C07F9/65846 ,  A61K47/6851 ,  C07K16/30

摘要： The present invention relates to novel derivatives of oxazaphosphorines that are pre-activated, to the methods for preparing same, to the pharmaceutical compositions containing same and to the therapeutic use thereof, in particular for treating cancer.

公开(公告)号：US08119403B2

公开(公告)日：2012-02-21

申请号：US12718084

申请日：2010-03-05

申请人： William L. Warren ,  Russell Higbee ,  Eric Mishkin ,  Guzman Sanchez-Schmitz ,  Heather Fahlenkamp ,  Michael Rivard

发明人： William L. Warren ,  Russell Higbee ,  Eric Mishkin ,  Guzman Sanchez-Schmitz ,  Heather Fahlenkamp ,  Michael Rivard

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12M21/08 ,  C12M25/14 ,  C12M35/08 ,  C12N5/0697 ,  C12N2501/21 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/11 ,  C12N2502/28 ,  C12N2502/30 ,  C12N2503/04 ,  C12N2531/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2535/10 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2800/24

摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.

摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括细胞培养物，其包含包含淋巴组织的三维基质，包含上皮和/或内皮细胞的三维基质和患病细胞。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药​​物，生物制剂和其它化学品的体外试验。

公开(公告)号：US07709256B2

公开(公告)日：2010-05-04

申请号：US11453003

申请日：2006-06-15

申请人： William L. Warren ,  Russell Higbee ,  Eric Mishkin ,  Guzman Sanchez-Schmitz ,  Heather Fahlenkamp ,  Michael Rivard

发明人： William L. Warren ,  Russell Higbee ,  Eric Mishkin ,  Guzman Sanchez-Schmitz ,  Heather Fahlenkamp ,  Michael Rivard

IPC分类号： C12N5/06

CPC分类号： C12M21/08 ,  C12M25/14 ,  C12M35/08 ,  C12N5/0697 ,  C12N2501/21 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/11 ,  C12N2502/28 ,  C12N2502/30 ,  C12N2503/04 ,  C12N2531/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2535/10 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2800/24

摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.

摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括细胞培养物，其包含包含淋巴组织的三维基质，包含上皮和/或内皮细胞的三维基质和患病细胞。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药​​物，生物制剂和其它化学品的体外试验。

公开(公告)号：US20100011717A1

公开(公告)日：2010-01-21

申请号：US12502405

申请日：2009-07-14

申请人： Michael Rivard

发明人： Michael Rivard

IPC分类号： B30B9/30 ,  B65D71/06

CPC分类号： B30B9/3003 ,  B30B9/3096

摘要： The present subject matter provides methods and apparatus for packaging wood mulch. Examples include a wood mulch bale produced using a method comprising compressing wood mulch at a pressure of between 12,000 pounds and 60,000 pounds to form a volume of compressed wood mulch and disposing a band about the compressed volume of wood mulch, wherein the compressed volume of wood mulch is between about 3000 cubic inches and about 5400 cubic inches. Other variations are provided herein.

摘要翻译： 本发明提供了用于包装木地板的方法和装置。 实例包括使用包括在12,000磅和6万磅之间的压力下压缩木地板以形成一定体积的压缩木地板并且围绕压缩体积的木地板设置带的方法生产的木地板包，其中压缩体积的木材 覆盖在约3000立方英寸至约5400立方英寸之间。 本文提供了其他变体。

公开(公告)号：US08096234B2

公开(公告)日：2012-01-17

申请号：US12502405

申请日：2009-07-14

申请人： Michael Rivard

发明人： Michael Rivard

IPC分类号： B30B13/00

CPC分类号： B30B9/3003 ,  B30B9/3096

摘要： The present subject matter provides methods and apparatus for packaging wood mulch. Examples include a wood mulch bale produced using a method comprising compressing wood mulch at a pressure of between 12,000 pounds and 60,000 pounds to form a volume of compressed wood mulch and disposing a band about the compressed volume of wood mulch, wherein the compressed volume of wood mulch is between about 3000 cubic inches and about 5400 cubic inches. Other variations are provided herein.

摘要翻译： 本发明提供了用于包装木地板的方法和装置。 实例包括使用包括在12,000磅和6万磅之间的压力下压缩木地板以形成一定体积的压缩木地板并且围绕压缩体积的木地板设置带的方法生产的木地板包，其中压缩体积的木材 覆盖在约3000立方英寸至约5400立方英寸之间。 本文提供了其他变体。

公开(公告)号：US20100159443A1

公开(公告)日：2010-06-24

申请号：US12718084

申请日：2010-03-05

申请人： William L. WARREN ,  Russell HIGBEE ,  Eric MISHKIN ,  Guzman SANCHEZ-SCHMITZ ,  Heather FAHLENKAMP ,  Michael RIVARD

发明人： William L. WARREN ,  Russell HIGBEE ,  Eric MISHKIN ,  Guzman SANCHEZ-SCHMITZ ,  Heather FAHLENKAMP ,  Michael RIVARD

IPC分类号： C12Q1/70 ,  C12Q1/02

CPC分类号： C12M21/08 ,  C12M25/14 ,  C12M35/08 ,  C12N5/0697 ,  C12N2501/21 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/11 ,  C12N2502/28 ,  C12N2502/30 ,  C12N2503/04 ,  C12N2531/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2535/10 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2800/24

摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.

摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括细胞培养物，其包含包含淋巴组织的三维基质，包含上皮和/或内皮细胞的三维基质和患病细胞。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药​​物，生物制剂和其它化学品的体外试验。

公开(公告)号：US5724851A

公开(公告)日：1998-03-10

申请号：US641455

申请日：1996-04-30

申请人： Michael Rivard

发明人： Michael Rivard

IPC分类号： B60G11/10 ,  B21D7/022 ,  B21D11/00 ,  B21D53/00 ,  B21D53/88 ,  B21D19/12

CPC分类号： B21D53/886 ,  B21D7/022

摘要： Apparatus (100) and method are provided for forming an eye at the end of a heated leaf spring blank (2). Apparatus (100) includes a forming plate (16) operative to move angularly downwardly against a cantilevered portion (10) of blank (2) and roll it about a retractable rotary eye pin (5) to form the eye. Apparatus (100) includes neutralizing the force created by forming plate (16) against blank (2) during the rolling operation and further preferably includes a scarf blade (14) operative to move angularly to scarf or shape the end of portion (10) prior to the rolling operation.

摘要翻译： 提供了用于在加热的板簧（2）的端部处形成眼睛的装置（100）和方法。 设备（100）包括成形板（16），其可操作成角度地向下移动抵靠坯料（2）的悬臂部分（10）并将其卷绕在可伸缩的旋转针销（5）上以形成眼睛。 设备（100）包括在轧制操作期间中和由板（16）形成板坯（2）而产生的力，并且还优选地包括可操作以有角度地移动到围绕或形成部分（10）的端部的围绕刀片（14） 到滚动操作。