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![6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist](/abs-image/US/2012/02/02/US20120028961A1/abs.jpg.150x150.jpg)
1.发明申请6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist 失效6-取代2,3,4,5四氢-1H-苯并[d]氮杂环庚烷为5-HT2c受体激动剂公开(公告)号：US20120028961A1
公开(公告)日：2012-02-02
申请号：US13192707
申请日：2011-07-28
申请人： JOHN GORDON ALLEN , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip MAZANETZ
发明人： JOHN GORDON ALLEN , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip MAZANETZ
CPC分类号： C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —S—R14; and other substituents are as defined in the specification.
摘要翻译： 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂，用于治疗5-HT 2C相关病症，包括肥胖，强迫症/强迫症 ，抑郁症和焦虑症：其中：R6为-S-R14; 和其它取代基如说明书中所定义。
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![6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/abs-image/US/2011/09/20/US08022062B2/abs.jpg.150x150.jpg)
2.发明授权6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists 有权6-取代的2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂公开(公告)号：US08022062B2
公开(公告)日：2011-09-20
申请号：US10598302
申请日：2005-02-18
申请人： John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Michael Philip Mazanetz
发明人： John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Michael Philip Mazanetz
IPC分类号： A61P3/04 , A61P25/22 , A61P25/24 , A61P25/30 , A61K31/55 , C07D223/16 , C07D401/12 , C07D417/12 , C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/14 , C07D417/06 , C07D403/06
CPC分类号： C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —C≡C—R10, —O—R12, —S—R14, or —NR24R25; and other substituents are as defined in the specification.
摘要翻译： 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂，用于治疗5-HT 2C相关病症，包括肥胖，强迫症/强迫症 ，抑郁症和焦虑症：其中：R6是-C≡C-R10，-O-R12，-S-R14或-NR24R25; 和其它取代基如说明书中所定义。
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公开(公告)号：US06323176B1
公开(公告)日：2001-11-27
申请号：US09245572
申请日：1999-02-05
IPC分类号： A61K3800
摘要： The present invention relates to compounds of formula where R5 is a sugar moiety. The compounds are useful in inhibiting fungal and parasitic activity and infections.
摘要翻译： 本发明涉及制剂的化合物，其中R5是糖部分。 该化合物可用于抑制真菌和寄生虫的活动和感染。
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![6 substituted 2, 3,4,5 tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonist](/abs-image/US/2013/11/12/US08580780B2/abs.jpg.150x150.jpg)
4.发明授权6 substituted 2, 3,4,5 tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonist 失效6-取代的2,3,4,5四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂公开(公告)号：US08580780B2
公开(公告)日：2013-11-12
申请号：US13192707
申请日：2011-07-28
申请人： John Gordon Allen , Karin Briner , Christopher Stanley Galka , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Deyi Zhang , Steven Armen Boyd , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh
发明人： John Gordon Allen , Karin Briner , Christopher Stanley Galka , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Deyi Zhang , Steven Armen Boyd , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh
IPC分类号： A61P3/04 , A61P25/22 , A61P25/24 , A61P25/30 , A61K31/55 , C07D223/16 , C07D401/12 , C07D417/12 , C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/14 , C07D417/06 , C07D403/06
CPC分类号： C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —S—R14; and other substituents are as defined in the specification.
摘要翻译： 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂，用于治疗5-HT 2C相关病症，包括肥胖，强迫症/强迫症 ，抑郁症和焦虑症：其中：R6为-S-R14; 和其它取代基如说明书中所定义。
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公开(公告)号：US5919756A
公开(公告)日：1999-07-06
申请号：US847069
申请日：1997-05-01
摘要： The present invention is directed to amides of antibiotic A82846B (also known as chloroorienticin A), and of N.sup.4 -derivatives of A82846B. The present amide compounds are useful as antibacterials, especially for the control of gram positive bacteria; the compounds are particularly useful for the control of resistant bacterial strains, such as vancomycin-resistant-enterococci ("VRE").
摘要翻译： 本发明涉及抗生素A82846B（也称为氯霉素A）和A82846B的N4衍生物的酰胺。 本发明的酰胺化合物可用作抗细菌剂，特别是用于控制革兰氏阳性细菌; 该化合物特别可用于控制抗性细菌菌株，例如耐万古霉素 - 肠球菌（“VRE”）。
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![6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS](/abs-image/US/2009/04/16/US20090099155A1/abs.jpg.150x150.jpg)
6.发明申请6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS 有权6-取代的2,3,4,5-四氢-1H-苯并[D]亚胺酯作为5-HT 2C受体激动剂公开(公告)号：US20090099155A1
公开(公告)日：2009-04-16
申请号：US10598302
申请日：2005-09-09
申请人： John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip Mazanetz
发明人： John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip Mazanetz
IPC分类号： A61K31/55 , C07D223/16 , C07D417/12 , C07D401/12 , A61P3/04 , A61P25/22 , C07D409/12 , C07D403/12 , C07D405/12
CPC分类号： C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzoazepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is -C≡C-R10, -O-R12, -S-R14, or -NR24R25; and other substituents are as defined in the specification.
摘要翻译： 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并吖庚因作为选择性5-HT 2C受体激动剂用于治疗5-HT2C相关疾病，包括肥胖，强迫症/强迫症，抑郁症和 焦虑：其中：R6为-C≡C-R10，-O-R12，-S-R14或-NR24R25; 和其它取代基如说明书中所定义。
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