发明授权
US08022062B2 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
有权
6-取代的2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂
![6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/docs/US/2011-09-20/US08022062B2/abs.jpg.600x600.jpg)
- 专利标题： 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
- 专利标题（中）： 6-取代的2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂
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申请号： US10598302申请日： 2005-02-18
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公开(公告)号： US08022062B2公开(公告)日： 2011-09-20
- 发明人: John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Michael Philip Mazanetz
- 申请人： John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Michael Philip Mazanetz
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 R. Craig Tucker
- 国际申请： PCT/US2005/005418 WO 20050218
- 国际公布： WO2005/082859 WO 20050909
- 主分类号： A61P3/04
- IPC分类号： A61P3/04 ; A61P25/22 ; A61P25/24 ; A61P25/30 ; A61K31/55 ; C07D223/16 ; C07D401/12 ; C07D417/12 ; C07D413/12 ; C07D403/12 ; C07D409/12 ; C07D405/12 ; C07D413/14 ; C07D417/06 ; C07D403/06
![6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/abs-image/US/2011/09/20/US08022062B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —C≡C—R10, —O—R12, —S—R14, or —NR24R25; and other substituents are as defined in the specification.
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