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公开(公告)号：US20140219924A1
公开(公告)日：2014-08-07
申请号：US14126034
申请日：2012-05-31
Applicant: Hideki Hayashi , Hiroya Hatakeyama , Masanori Fujinami , Taro Toyota
Inventor： Hideki Hayashi , Hiroya Hatakeyama , Masanori Fujinami , Taro Toyota
CPC classification number: A61K49/0034 , A61K49/0002 , A61K49/0023 , A61K49/006 , A61K49/0084 , A61K49/0438 , A61K49/0461 , A61K49/0466
Abstract: The present invention is to provide a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also to provide a manufacturing method for the medical tissue-marker. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by means of an emulsifier.
Abstract translation: 本发明提供一种能够从器官外部识别位置的医疗组织标记物，能够长时间保持局部，能够容易地识别整个器官内的标记位置; 也提供了用于医疗组织标记物的制造方法。 本发明中的医疗用组织标记物包括通过合成磷脂和近红外荧光染料形成的囊泡，以及通过合成磷脂和X射线造影剂形成的乳液，并且具有团聚体，其中， 囊泡和乳液包含在亲水溶剂中，并且通过乳化剂形成多个胶囊。
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公开(公告)号：US09302018B2
公开(公告)日：2016-04-05
申请号：US13700780
申请日：2011-05-31
Applicant: Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
Inventor： Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
IPC: A61K49/00 , C07D209/60 , C09B23/08
CPC classification number: C09B23/083 , A61K9/127 , A61K49/0032 , A61K49/0034 , A61K49/0084 , C07D209/60 , C09B23/086
Abstract: Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
Abstract translation: 公开了包含吲哚菁系荧光染料和脂质体的近红外荧光显影剂。 本发明的近红外荧光显像剂在前哨淋巴结中表现出高荧光强度和长锚定时间，从而可用于检测前哨淋巴结导航手术中的前哨淋巴结。 还公开了特别适用于本发明的近红外荧光显影剂的吲哚菁绿衍生物。
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公开(公告)号：US20130129631A1
公开(公告)日：2013-05-23
申请号：US13700780
申请日：2011-05-31
Applicant: Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
Inventor： Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
CPC classification number: C09B23/083 , A61K9/127 , A61K49/0032 , A61K49/0034 , A61K49/0084 , C07D209/60 , C09B23/086
Abstract: Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
Abstract translation: 公开了包含吲哚菁系荧光染料和脂质体的近红外荧光显影剂。 本发明的近红外荧光显像剂在前哨淋巴结中表现出高荧光强度和长锚定时间，从而可用于检测前哨淋巴结导航手术中的前哨淋巴结。 还公开了特别适用于本发明的近红外荧光显影剂的吲哚菁绿衍生物。
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公开(公告)号：US10022459B2
公开(公告)日：2018-07-17
申请号：US14126034
申请日：2012-05-31
Applicant: Hideki Hayashi , Hirosuke Hatayama , Masanori Fujinami , Taro Toyota
Inventor： Hideki Hayashi , Hirosuke Hatayama , Masanori Fujinami , Taro Toyota
Abstract: A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.
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