公开(公告)号：US20140219924A1

公开(公告)日：2014-08-07

申请号：US14126034

申请日：2012-05-31

Applicant: Hideki Hayashi ,  Hiroya Hatakeyama ,  Masanori Fujinami ,  Taro Toyota

Inventor： Hideki Hayashi ,  Hiroya Hatakeyama ,  Masanori Fujinami ,  Taro Toyota

IPC: A61K49/00 ,  A61K49/04

CPC classification number: A61K49/0034 ,  A61K49/0002 ,  A61K49/0023 ,  A61K49/006 ,  A61K49/0084 ,  A61K49/0438 ,  A61K49/0461 ,  A61K49/0466

Abstract: The present invention is to provide a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also to provide a manufacturing method for the medical tissue-marker. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by means of an emulsifier.

Abstract translation: 本发明提供一种能够从器官外部识别位置的医疗组织标记物，能够长时间保持局部，能够容易地识别整个器官内的标记位置; 也提供了用于医疗组织标记物的制造方法。 本发明中的医疗用组织标记物包括通过合成磷脂和近红外荧光染料形成的囊泡，以及通过合成磷脂和X射线造影剂形成的乳液，并且具有团聚体，其中， 囊泡和乳液包含在亲水溶剂中，并且通过乳化剂形成多个胶囊。