知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

5 records (took 0.01 seconds)

    Neurotensin Hexapeptides
    1.
    发明授权
    Neurotensin Hexapeptides 失效
    神经降压肽六肽

    公开(公告)号：US5393740A

    公开(公告)日：1995-02-28

    申请号：US920878

    申请日：1992-07-28

    Applicant: Sakae Amagaya ,  Tadami Fujiwara ,  Masaki Aburada ,  Michio Nagasawa ,  Tsutomu Oyama

    Inventor： Sakae Amagaya ,  Tadami Fujiwara ,  Masaki Aburada ,  Michio Nagasawa ,  Tsutomu Oyama

    IPC: A61K38/00 ,  A61P3/00 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K5/10 ,  C07K7/06 ,  A61K37/00 ,  C07K5/00 ,  C07K7/00 ,  A61K37/02

    CPC classification number: C07K7/06 ,  A61K38/00

    Abstract: A hexapeptide represented by formula (II):A-B-Pro-C-D-E (I)where A represents an L- or D- form of arginine or lysine whose N-terminal amino group is alkylated or acylated, B represents an L- or D- form of argine, lysine, or histidine, Pro represents an L- or D- form of proline, C represents an L- or D- form of tyrosine, tryptophan, or phenylalanine, D represents an L- or D- form of valine, isolencine, or leucine, and E represents an L-or D- form of valine, isolencine, or lencine, one of the hydrogen atoms of the amino group of which may be substituted a C.sub.1 to C.sub.4 alkyl group, and C-terminal carboxyl group of which is substituted with --COOR*, --CH.sub.2 OR, or --CONHR wherein R* represents a C.sub.1 to C.sub.4 alkyl group, and R represents a hydrogen atom or an C.sub.1 to C.sub.4 alkyl group. The hexapeptide or a pharmaceutically acceptable salt of the hexapeptide is useful as medical agent such as an anti-edematous agent, an anti-shock agent, an anti-thrombus agent, an anti-arteriosclerotic agent, an anti-allergic agent, a hypotensive agent, a wound healing agent, and an anti-inflammatory agent.

    Abstract translation: 由式（II）表示的六肽：AB-Pro-CDE（I）其中A表示其N-末端氨基被烷基化或酰化的L-或D-型精氨酸或赖氨酸，B表示L-或D- 氨基酸，赖氨酸或组氨酸的形式，Pro代表L-或D-形式的脯氨酸，C代表L-或D-形式的酪氨酸，色氨酸或苯丙氨酸，D表示L-或D-形式的缬氨酸， 异亮氨酸或亮氨酸，E表示缬氨酸，异亮氨酸或氨基酸的L-型或D-型，其氨基的一个氢原子可被C1-C4烷基取代，C-末端羧基 被-COOR *，-CH 2 OR或-CONHR取代，其中R *表示C1至C4烷基，R表示氢原子或C1至C4烷基。 六肽的六肽或药学上可接受的盐可用作药剂，例如抗水肿剂，抗休克剂，抗血栓剂，抗动脉硬化剂，抗过敏剂，降血压剂 ，伤口愈合剂和抗炎剂。

Patent Agency Ranking