公开(公告)号：US20140348961A1

公开(公告)日：2014-11-27

申请号：US14368457

申请日：2012-12-27

Applicant: Masaki ABURADA ,  TOKIWA PHYTOCHEMICAL CO., LTD.

Inventor： Tsutomu Shimada ,  Jinwei Yang ,  Yuka Koike

IPC: C07D311/32 ,  A23L2/52 ,  A23L1/30 ,  A61K36/9068

CPC classification number: C07D311/32 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/498 ,  A61K8/97 ,  A61K31/352 ,  A61K36/9068 ,  A61K2236/00 ,  A61K2800/10 ,  A61K2800/78 ,  A61Q19/00 ,  A23V2200/302 ,  A23V2200/304 ,  A23V2200/308 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2250/2112 ,  A61K2300/00

Abstract: The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher: wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.

Abstract translation: 本发明提供了一种具有由黑姜或黑姜提取物组成的活性成分的沉默调节因子活化剂，其可以容易地获得，非常安全，并且从旧食用。 本发明还提供了一种具有由通式（I）表示的聚烷氧基类黄酮化合物的活性成分并且具有白藜芦醇或更高的10倍的沉默调节蛋白激活作用的沉默调节蛋白激活剂：其中，R 1至R 7各自独立地为氢原子， 羟基或C1〜C6低级烷氧基。

公开(公告)号：US09745279B2

公开(公告)日：2017-08-29

申请号：US14368457

申请日：2012-12-27

Applicant: TOKIWA PHYTOCHEMICAL CO., LTD. ,  Masaki Aburada

Inventor： Tsutomu Shimada ,  Jinwei Yang ,  Yuka Koike

IPC: A61K36/00 ,  C07D311/32 ,  A61K31/352 ,  A23L2/52 ,  A61K36/9068 ,  A61K8/49 ,  A61Q19/00 ,  A61K8/97 ,  A23L33/105

CPC classification number: C07D311/32 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/498 ,  A61K8/97 ,  A61K31/352 ,  A61K36/9068 ,  A61K2236/00 ,  A61K2800/10 ,  A61K2800/78 ,  A61Q19/00 ,  A23V2200/302 ,  A23V2200/304 ,  A23V2200/308 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2250/2112 ,  A61K2300/00

Abstract: The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher: wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.

公开(公告)号：US11452756B2

公开(公告)日：2022-09-27

申请号：US16854462

申请日：2020-04-21

Applicant: Tokiwa Phytochemical Co., Ltd.

Inventor： Jinwei Yang ,  Tomoko Kuniyoshi

IPC: A23L33/105 ,  A61K36/906 ,  A61K8/9794 ,  A61P17/00 ,  A61P1/10 ,  A61P27/02

Abstract: The present invention relates to a composition and method for improving the quantity of tear fluid, a composition and method for treating constipation, and a composition and method for improving skin quality. By utilizing an extract of Black ginger (Kaempferia parviflora)), the quantity of tear fluid, constipation, and skin quality are improved.

公开(公告)号：US11154581B2

公开(公告)日：2021-10-26

申请号：US16740843

申请日：2020-01-13

Applicant: TOKIWA PHYTOCHEMICAL CO., LTD.

Inventor： Jinwei Yang

IPC: A61K36/45 ,  A61K31/352

Abstract: A composition and method for the prevention and/or improvement of dry eye syndrome, dryness of eye and/or stiff neck and shoulder, which contains bilberry fruit extract and is effective with less intake are provided. As one aspect of the present invention, the composition for the prevention or improvement of dry eye syndrome or dryness of eye contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, the composition for the prevention or improvement of stiff neck and shoulder contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, a composition for the prevention or improvement of dry eye syndrome, dryness of eye, and stiff neck and shoulder, contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, a method using a bilberry fruit extract for the improvement of stiff neck and shoulder is provided.