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    Device and Method for the Gravimetric Determination of Liquid Volumes and Analyzer System Comprising Such a Device
    1.
    发明申请
    Device and Method for the Gravimetric Determination of Liquid Volumes and Analyzer System Comprising Such a Device 有权
    用于重量测定液体体积的装置和方法以及包括这种装置的分析仪系统

    公开(公告)号：US20080257039A1

    公开(公告)日：2008-10-23

    申请号：US12053738

    申请日：2008-03-24

    申请人： Markus Thiel ,  Philipp Kull ,  Daniel Ott ,  Joerg Burmester

    发明人： Markus Thiel ,  Philipp Kull ,  Daniel Ott ,  Joerg Burmester

    IPC分类号： G01V7/00

    CPC分类号： G01G17/06 ,  G01G21/30 ,  Y10T436/2575

    摘要： A device for the gravimetric volume determination of liquid volumes. The device comprises a housing (11) having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the following components contained in housing (11): a load cell (12) for gravimetric volume determination, a weighing container (13) for receiving a liquid to be weighed with said load cell (12), a windbreak (14) which shields said weighing container (13) from air flow, an evaporation trap (15) which prevents evaporation of liquid loaded into said weighing container (13), a temperature sensor (21), an air-pressure sensor (31) and a humidity sensor (41) for sensing temperature, air pressure and humidity respectively at predetermined points within said housing (11), and an electronic processing unit for processing electrical output signals delivered by said load cell (12) and by said sensors (21, 31, 41).

    摘要翻译： 液体体积重量体积测定装置。 该装置包括具有用于保存样品或试剂容器的临床诊断分析仪系统中使用的标准架的形状和尺寸的壳体（11），以及包含在壳体（11）中的以下部件：用于重量的负载传感器 体积确定，用于接收与所述称重传感器（12）进行称重的液体的称重容器（13），将所述称重容器（13）遮挡空气流的防风罩（14），防止蒸发的蒸发阱（15） 装载到所述称重容器（13）中的液体，温度传感器（21），空气压力传感器（31）和湿度传感器（41），用于分别在所述壳体（11）内的预定点处感测温度，空气压力和湿度 ）和用于处理由所述测力传感器（12）和所述传感器（21,31,41）传送的电输出信号的电子处理单元。

    Antibodies Directed Against HLA-B27 Homodimers and Methods and Uses Thereof in Diagnosis and Therapy
    2.
    发明申请
    Antibodies Directed Against HLA-B27 Homodimers and Methods and Uses Thereof in Diagnosis and Therapy 审中-公开
    针对HLA-B27同源二聚体的抗体及其在诊断和治疗中的用途及其用途

    公开(公告)号：US20130315933A1

    公开(公告)日：2013-11-28

    申请号：US13877958

    申请日：2011-10-06

    申请人： Christoph Renner ,  Andreas Wadle ,  Sravan Payeli ,  Markus Thiel ,  Paul Bowness ,  Simon Kollnberger

    发明人： Christoph Renner ,  Andreas Wadle ,  Sravan Payeli ,  Markus Thiel ,  Paul Bowness ,  Simon Kollnberger

    IPC分类号： C07K16/28

    CPC分类号： C07K16/28 ,  C07K16/2833 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76

    摘要： Specific binding members, particularly antibodies and fragments thereof, which bind to HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which do not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with β2 microglobulin and peptide. These antibodies are useful in the diagnosis and treatment of HLA-B27 mediated conditions, particularly those associated with B272, the spondylarthritides, a group of related diseases including ankylosing spondylitis (AS) and reactive arthritis (ReA or Reiter's syndrome). The antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, anti-inflammatory drugs, NSAIDs and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies HD4, HD5 and HD6 whose sequences are provided herein.

    摘要翻译： 特异性结合成员，特别是抗体及其片段，其结合HLA-B27重链同源二聚体，称为HC-B27，HLA-B272或B272，特别是识别B272同型二聚体并且不识别或结合HLA-B27异源三聚体（B27） 包括具有β2微球蛋白和肽的HLA-B27异源二聚体。 这些抗体可用于诊断和治疗HLA-B27介导的病症，特别是与B272相关的那些，脊椎关节炎，一组相关疾病，包括强直性脊柱炎（AS）和反应性关节炎（ReA或Reiter综合征））。 本发明的抗体，可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂，抗炎药物，NSAIDs和/或与其它抗体或其片段组合的治疗中。 这种抗体的例子是本文提供其序列的新型抗体HD4，HD5和HD6。

    Device and method for the gravimetric determination of liquid volumes and analyzer system comprising such a device
    4.
    发明授权
    Device and method for the gravimetric determination of liquid volumes and analyzer system comprising such a device 有权
    用于重量测定液体体积的装置和方法以及包括这种装置的分析仪系统

    公开(公告)号：US07829800B2

    公开(公告)日：2010-11-09

    申请号：US12053738

    申请日：2008-03-24

    申请人： Markus Thiel ,  Philipp Kull ,  Daniel Ott ,  Joerg Burmester

    发明人： Markus Thiel ,  Philipp Kull ,  Daniel Ott ,  Joerg Burmester

    IPC分类号： G01G21/28 ,  G01F23/20 ,  B01L1/00

    CPC分类号： G01G17/06 ,  G01G21/30 ,  Y10T436/2575

    摘要： A device for the gravimetric volume determination of liquid volumes. The device comprises a housing (11) having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the following components contained in housing (11): a load cell (12) for gravimetric volume determination, a weighing container (13) for receiving a liquid to be weighed with said load cell (12), a windbreak (14) which shields said weighing container (13) from air flow, an evaporation trap (15) which prevents evaporation of liquid loaded into said weighing container (13), a temperature sensor (21), an air-pressure sensor (31) and a humidity sensor (41) for sensing temperature, air pressure and humidity respectively at predetermined points within said housing (11), and an electronic processing unit for processing electrical output signals delivered by said load cell (12) and by said sensors (21, 31, 41).

    摘要翻译： 液体体积重量体积测定装置。 该装置包括具有用于保存样品或试剂容器的临床诊断分析仪系统中使用的标准架的形状和尺寸的壳体（11），以及包含在壳体（11）中的以下部件：用于重量的负载传感器 体积确定，用于接收与所述称重传感器（12）进行称重的液体的称重容器（13），将所述称重容器（13）遮挡空气流的防风罩（14），防止蒸发的蒸发阱（15） 装载到所述称重容器（13）中的液体，温度传感器（21），空气压力传感器（31）和湿度传感器（41），用于分别在所述壳体（11）内的预定点处感测温度，空气压力和湿度 ）和用于处理由所述测力传感器（12）和所述传感器（21,31,41）传送的电输出信号的电子处理单元。