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公开(公告)号：US20120207769A1
公开(公告)日：2012-08-16
申请号：US13456274
申请日：2012-04-26
Applicant: Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
Inventor： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC: A61K31/40 , A61K31/663 , A61K31/55 , A61K31/53 , A61K31/519 , A61K31/497 , A61K31/506 , A61K31/437 , A61K31/444 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4025 , A61P35/00 , A61P5/26 , A61K39/395
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
Abstract translation: 抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。
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公开(公告)号：US20110281875A1
公开(公告)日：2011-11-17
申请号：US13178946
申请日：2011-07-08
Applicant: Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
Inventor： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC: A61K31/53 , A61K31/444 , C07D401/04 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4155 , A61K31/4025 , A61K31/40 , C07D401/14 , A61K31/4439 , C07D413/04 , C07D417/04 , C07D403/04 , C07D207/16 , A61K31/506
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
Abstract translation: 抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。
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公开(公告)号：US07807842B2
公开(公告)日：2010-10-05
申请号：US11133789
申请日：2005-05-20
Applicant: Andrew G. Myers , Mark G. Charest , Christian D. Lerner , Jason D. Brubaker , Dionicio R. Siegel
Inventor： Andrew G. Myers , Mark G. Charest , Christian D. Lerner , Jason D. Brubaker , Dionicio R. Siegel
IPC: C07D413/00
CPC classification number: C07D261/20 , C07C231/10 , C07C237/26 , C07D209/56 , C07D209/58 , C07D213/56 , C07D221/18 , C07D235/02 , C07D237/26 , C07D239/70 , C07D241/38 , C07D263/52 , C07D277/30 , C07D277/56 , C07D277/64 , C07D277/66 , C07D307/77
Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
Abstract translation: 四环素类抗生素在过去50年的传染病治疗中发挥了重要作用。 然而，四环素在人类和兽医药物中的使用量的增加已经导致了以前易受四环素抗生素影响的许多生物体之间的抵抗。 所描述的四环素和四环素类似物的模块合成为通过先前的四环素合成和半合成方法先前难以接近的各种四环素类似物和聚环状体提供了有效和对映选择性的途径。 这些类似物可以用作抗微生物剂或抗增殖剂来治疗人类或其他动物的疾病。
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公开(公告)号：US20080242658A1
公开(公告)日：2008-10-02
申请号：US10594413
申请日：2005-04-06
Applicant: Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
Inventor： Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC: A61K31/407 , C07D471/04 , C07D207/08 , C07D487/04 , C07D207/32 , A61P35/00 , A61K31/4439 , A61K31/422 , A61K31/41 , A61K31/506 , C07D401/04 , C07D403/12 , A61K31/437 , A61K31/55 , A61K31/40
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
Abstract translation: 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物
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公开(公告)号：US07419975B2
公开(公告)日：2008-09-02
申请号：US11099941
申请日：2005-04-06
Applicant: Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
Inventor： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC: A61K31/407 , A61K31/437 , A61K31/55 , C07D487/04 , C07D471/04
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
Abstract translation: 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物
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Patent Agency Ranking
公开(公告)号：US20140004101A1
公开(公告)日：2014-01-02
申请号：US14013666
申请日：2013-08-29
Applicant: Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: C07D417/04 , A61K31/427 , A61K45/06
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20110015232A1
公开(公告)日：2011-01-20
申请号：US12445435
申请日：2007-10-10
Applicant: Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
Inventor： Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
IPC: A61K31/4439 , C07D405/14 , C07D401/14 , C12N5/07
CPC classification number: C07K5/06191
Abstract: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
Abstract translation: 本发明涉及式（I）的新型IAP抑制剂化合物。
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![(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses](/abs-image/US/2013/10/08/US08552003B2/abs.jpg.150x150.jpg)
8.发明授权(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses 有权（S）-N - （（S）-1-环己基-2 - {（S）-2- [4-4-（4-氟苯甲酰基） - 噻唑-2-基]吡咯烷-1-基} -2- 氧代乙基）-2-甲基氨基 - 丙酰胺或其药学上可接受的盐及其用途公开(公告)号：US08552003B2
公开(公告)日：2013-10-08
申请号：US12376057
申请日：2007-07-31
Applicant: Mark G. Charest , Christine Hiu-Tung Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Mark G. Charest , Christine Hiu-Tung Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: A01N43/54
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20130005663A1
公开(公告)日：2013-01-03
申请号：US13606676
申请日：2012-09-07
Applicant: Mark G. CHAREST , Christine Hiu-Tung CHEN , Zhuoliang CHEN , Miao DAI , Feng HE , Huangshu LEI , Ly Luu PHAM , Sushil Kumar SHARMA , Christopher Sean STRAUB , Run-Ming David WANG , Fan YANG , Leigh ZAWEL
Inventor： Mark G. CHAREST , Christine Hiu-Tung CHEN , Zhuoliang CHEN , Miao DAI , Feng HE , Huangshu LEI , Ly Luu PHAM , Sushil Kumar SHARMA , Christopher Sean STRAUB , Run-Ming David WANG , Fan YANG , Leigh ZAWEL
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US08338440B2
公开(公告)日：2012-12-25
申请号：US13456274
申请日：2012-04-26
Applicant: Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
Inventor： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC: A61K31/427 , A61K31/4245 , A61K31/422 , A61K31/435 , A61K31/40 , A61K31/506 , A61K31/41
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
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