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公开(公告)号：US09999706B2
公开(公告)日：2018-06-19
申请号：US13642126
申请日：2011-03-24
CPC分类号： A61L27/34 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/406 , C08L5/08 , C08L89/06
摘要： Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.
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公开(公告)号：US06632470B2
公开(公告)日：2003-10-14
申请号：US09772908
申请日：2001-01-31
IPC分类号： B05D304
CPC分类号： A61L33/0094 , A61L33/0029 , A61L33/0088 , C23C16/0245
摘要： A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.
摘要翻译： 公开了一种改变设备表面的方法，例如医疗设备。 该方法包括通过提供器件来修饰器件的表面，将器件暴露于反应气体和等离子体能量以在器件上产生等离子体沉积表面，并用反应气体淬火器件。 该装置表现出其表面性质的改变，从而使其更适用于预期用途。
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3.发明授权Formed articles made of polymeric material and having improved surface characteristics and process for producing them 失效由聚合材料制成并具有改进的表面特性的成型制品及其制造方法
公开(公告)号：US5322737A
公开(公告)日：1994-06-21
申请号：US132217
申请日：1993-10-06
申请人： Marco Morra , Ernesto Occhiello , Fabio Garbassi
发明人： Marco Morra , Ernesto Occhiello , Fabio Garbassi
CPC分类号： C08J7/047 , C08J7/18 , C09D133/14 , C08J2433/00 , Y10T428/31507 , Y10T428/3175 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928
摘要： Formed articles having improved surface properties, such as wettability, printability, adhesion, antistaticity and clouding resistance, consisting of a polymeric finished article or semi-finished article coated on at least a surface with a polyhydroxethylacrylate layer, preferably prepared by means of plasma polymerization.
摘要翻译： 优选通过等离子体聚合制备的具有改进的表面性能，例如润湿性，可印刷性，粘合性，抗静电性和耐白浊性的成型制品，其由涂覆有至少表面的聚合物羟丙基甲基丙烯酸酯层的聚合物成品或半成品制成。
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4.发明申请IMPLANTABLE DEVICES HAVING ANTIBACTERIAL PROPERTIES AND MULTIFUNCTIONAL SURFACES 有权具有抗菌性能和多功能表面的可植入装置公开(公告)号：US20130197660A1
公开(公告)日：2013-08-01
申请号：US13642126
申请日：2011-03-24
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/406 , C08L5/08 , C08L89/06
摘要： Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.
摘要翻译： 提供了具有用于防止假体周围感染和改善骨整合能力的抗菌活性的可植入装置。 还提供了制造和使用这些装置的方法。
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公开(公告)号：US20110206754A1
公开(公告)日：2011-08-25
申请号：US13059865
申请日：2009-10-12
IPC分类号： A61M31/00 , A61K31/728 , A61P29/00 , C23C16/44 , C23C16/50 , B05D7/24 , B05D5/00 , A61B17/86
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , C08L5/08
摘要： The present description relates to an implant device, having an improved integration in the tissue of the animal or human body into which it is inserted, when compared to the prior art devices.Particularly, the present description relates to an implant device for the implant in animal or human body, comprising a hyaluronic acid coating, characterized in that said hyaluronic acid is low molecular weight hyaluronic acid or is composed of a mixture of low molecular weight hyaluronic acid and high molecular weight hyaluronic acid, wherein said low molecular weight hyaluronic acid has a molecular weight lower than 80,000 Dalton and said high molecular weight hyaluronic acid has a molecular weight higher than 700,000 Dalton.
摘要翻译： 本描述涉及一种植入装置，当与现有技术的装置相比时，其具有改进的整合入动物或人体的组织中。 特别地，本说明书涉及用于动物或人体内的植入物的植入装置，其包括透明质酸涂层，其特征在于，所述透明质酸是低分子量透明质酸，或由低分子量透明质酸和 高分子量透明质酸，其中所述低分子量透明质酸的分子量低于80,000道尔顿，所述高分子量透明质酸的分子量高于700,000道尔顿。
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6.发明授权
公开(公告)号：US5514424A
公开(公告)日：1996-05-07
申请号：US223816
申请日：1994-04-06
申请人： Marco Morra , Ernesto Occhiello , Fabio Gabrassi
发明人： Marco Morra , Ernesto Occhiello , Fabio Gabrassi
IPC分类号： F24C3/00 , B05D3/10 , B05D5/08 , B05D7/24 , C08J5/16 , C08J7/04 , C08J7/12 , F23N5/00 , G05D23/00 , C08J7/18
CPC分类号： B05D1/62 , B05D3/10 , B05D5/083 , C08J7/047 , C08J7/12 , B05D2201/02 , C08J2427/00
摘要： Process for reducing the friction coefficient between water, and, surfaces of fabricated bodies made from polymeric materials, and for increasing the water repellency of said surfaces, which process comprises treating the concerned surface with a corrosive solution, and coating it with a thin layer of fluorinated polymer.
摘要翻译： 用于降低水和由聚合材料制成的制造体的表面之间的摩擦系数以及用于增加所述表面的拒水性的方法，该方法包括用腐蚀性溶液处理相关表面，并用薄层 氟化聚合物。
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7.发明授权Process for the coating of objects with hyaluronic acid, derivatives thereof, and semisynthetic polymers 失效用透明质酸涂覆物体的方法，其衍生物和半合成聚合物
公开(公告)号：US6129956A
公开(公告)日：2000-10-10
申请号：US930858
申请日：1997-10-07
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085
摘要： Processes are provided for coating the surfaces of objects with hyaluronic acid, its derivatives or other natural or semisynthetic polymers, for applications in the fields of surgery, health care and diagnostics. The processes make it possible to bind such polymers in a stable manner to the surfaces of objects made of a wide range of materials. Surfaces treated according to the processes are characterized by a high degree of wettability, and are able to inhibit the adhesion of cells or bacteria present in the biological fluids.
摘要翻译： PCT No.PCT / EP96 / 00509 Sec。 371 1999年10月7日第 102（e）1999年10月7日PCT PCT 1996年2月7日PCT公布。 第WO96 / 24392号公报 日期1996年8月15日提供用于在物体表面涂覆透明质酸，其衍生物或其他天然或半合成聚合物的工艺，用于手术，保健和诊断领域的应用。 这些方法使得可以以稳定的方式将这些聚合物结合到由各种材料制成的物体的表面上。 根据该方法处理的表面的特征在于高润湿性，并且能够抑制存在于生物流体中的细胞或细菌的粘附。
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8.发明授权Process for coating, with inorganic films, the surface of bodies fabricated from polymeric materials 失效用无机膜涂覆由聚合材料制成的主体表面的方法
公开(公告)号：US5279853A
公开(公告)日：1994-01-18
申请号：US811968
申请日：1991-12-23
申请人： Ernesto Occhiello , Marco Morra , Fabio Garbassi
发明人： Ernesto Occhiello , Marco Morra , Fabio Garbassi
CPC分类号： C23C14/10
摘要： A process for coating the surface of bodies fabricated from polymeric materials with inorganic films by depositing on the polymeric bodies a thin layer obtained by thermal evaporation, under vacuum, of glass/silicon mixtures. The process provides for improved control of surface-depending properties, such as wettability, haze resistance, gas and weight barrier properties and selective absorption of ultraviolet light.
摘要翻译： 通过在聚合物体上沉积由玻璃/硅混合物在真空下热蒸发获得的薄层来涂覆由聚合材料制成的主体表面的方法。 该方法提供了改善表面依赖性质的控制，例如润湿性，防雾性，气体和重量阻隔性能以及紫外光的选择性吸收。
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9.发明授权
公开(公告)号：US5599698A
公开(公告)日：1997-02-04
申请号：US448029
申请日：1995-05-23
CPC分类号： C12P13/02 , D06M16/003 , D06P3/74 , D06P3/8209 , D06P3/854 , D06P5/22 , Y10S435/84
摘要： The invention relates to modified materials based on polyacrylonitrile having amidic groups on their surface. The modification gives the material greater hydrophilic characteristics improving its comfort properties. In addition, it permits the polyacrylonitrile to be dyed also with acidic dyes thus making it possible for it to be used for the preparation of yarns mixed with natural fibres, such as wool for example. The process for their production involves treatment of the material with enzymes of the nitrile hydratasis class obtained from Brevibacterium imperiale.
摘要翻译： 本发明涉及基于其表面具有酰胺基团的聚丙烯腈的改性材料。 该改性使材料具有更好的亲水性，从而改善其舒适性。 另外，它也可以用酸性染料染色聚丙烯腈，从而使其可用于制备与天然纤维例如羊毛等混合的纱线。 其生产过程涉及用从Brevibacterium imperiale获得的腈水合物类的酶处理材料。
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10.发明授权Method for grafting hydrophilic monomers containing double bonds onto formed bodies with polymer surfaces 失效将含有双键的亲水单体接枝到聚合物表面的成型体上的方法
公开(公告)号：US5304404A
公开(公告)日：1994-04-19
申请号：US955055
申请日：1992-10-01
申请人： Marco Morra , Ernesto Occhiello , Fabio Garbassi
发明人： Marco Morra , Ernesto Occhiello , Fabio Garbassi
CPC分类号： C08J7/18
摘要： A method for grafting hydrophilic monomers containing double bonds onto polymer surfaces in aqueous solution.The grafting is activated by ultraviolet radiation and by the presence in suspension of a photoactivator of controlled particle size distribution.
摘要翻译： 在水溶液中将含有双键的亲水单体接枝到聚合物表面上的方法。 接枝通过紫外线辐射和受控粒度分布的光活化剂的悬浮液的存在而被活化。
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