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1.发明申请公开(公告)号：US20100031377A1
公开(公告)日：2010-02-04
申请号：US11660015
申请日：2005-08-09
Applicant: Dale B Schenk , Eliezer Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
Inventor： Dale B Schenk , Eliezer Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
CPC classification number: C07K16/18 , A61K38/1709 , A61K39/00 , A61K2039/505 , A61P25/16 , A61P25/28
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
Abstract translation: 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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公开(公告)号：US20100278814A1
公开(公告)日：2010-11-04
申请号：US12037081
申请日：2008-02-25
Applicant: Dale B. Schenk , Eliezar Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
Inventor： Dale B. Schenk , Eliezar Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
IPC: A61K39/395 , C07K16/18 , A61P25/16 , A61P25/00
CPC classification number: C07K16/18 , A61K39/0007 , A61K2039/505 , A61K2039/55566 , A61K2039/6056 , C07K2317/34 , C07K2317/77 , C07K2317/80
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
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3.发明申请公开(公告)号：US20090208487A1
公开(公告)日：2009-08-20
申请号：US11710248
申请日：2007-02-23
Applicant: Dale B. Schenk , Kate Dora Games , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Eliezar Masliah
Inventor： Dale B. Schenk , Kate Dora Games , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Eliezar Masliah
IPC: A61K39/395 , C07K16/18 , C12N5/16 , A61K39/00 , A61P37/02
CPC classification number: A61K39/0007 , A61K2039/505 , A61K2039/55566 , C07K16/18 , C07K2317/34
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
Abstract translation: 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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4.发明申请公开(公告)号：US20160184416A1
公开(公告)日：2016-06-30
申请号：US14838206
申请日：2015-08-27
Applicant: Dale B. Schenk , Eliezer Masliah , Manuel J. Buttini , Chilcote J. Tamie , Edward Rockenstein , Kate Dora Games
Inventor： Dale B. Schenk , Eliezer Masliah , Manuel J. Buttini , Chilcote J. Tamie , Edward Rockenstein , Kate Dora Games
IPC: A61K39/00
CPC classification number: A61K39/0007 , A61K2039/505 , A61K2039/55566 , A61K2039/575 , C07K16/18 , C07K2317/34
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
Abstract translation: 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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公开(公告)号：US09272030B2
公开(公告)日：2016-03-01
申请号：US13642845
申请日：2011-04-22
Applicant: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini , Gene G. Kinney
Inventor： Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini , Gene G. Kinney
IPC: C07K16/18 , A61K39/00 , A61K39/395
CPC classification number: A61K39/3955 , A61K2039/505 , A61K2039/545 , A61K2039/55 , C07K16/18 , C07K2317/24 , C07K2317/34
Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
Abstract translation: 本发明提供了阿尔茨海默病和类似疾病的免疫治疗方法，其中通过测量tau的水平来监测施用的状态。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20120142902A1
公开(公告)日：2012-06-07
申请号：US13326228
申请日：2011-12-14
Applicant: Dale B. Schenk , Eliezer Masliah , Manuel J. Buttini , Chilcote J. Tamie , Edward Rockenstein , Kate Dora Games
Inventor： Dale B. Schenk , Eliezer Masliah , Manuel J. Buttini , Chilcote J. Tamie , Edward Rockenstein , Kate Dora Games
IPC: C07K16/18
CPC classification number: A61K39/0007 , A61K2039/505 , A61K2039/55566 , A61K2039/575 , C07K16/18 , C07K2317/34
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
Abstract translation: 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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7.发明授权Treatment and delay of outset of synucleinopathic and amyloidogenic disease 有权突触核蛋白病和淀粉样变性疾病的治疗和延迟开始公开(公告)号：US09034337B2
公开(公告)日：2015-05-19
申请号：US11710248
申请日：2007-02-23
Applicant: Dale B. Schenk , Eliezar Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
Inventor： Dale B. Schenk , Eliezar Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
CPC classification number: A61K39/0007 , A61K2039/505 , A61K2039/55566 , C07K16/18 , C07K2317/34
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
Abstract translation: 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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公开(公告)号：US20130209453A1
公开(公告)日：2013-08-15
申请号：US13642845
申请日：2011-04-22
Applicant: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini
Inventor： Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini
IPC: A61K39/395
CPC classification number: A61K39/3955 , A61K2039/505 , A61K2039/545 , A61K2039/55 , C07K16/18 , C07K2317/24 , C07K2317/34
Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
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公开(公告)号：US08092801B2
公开(公告)日：2012-01-10
申请号：US12037081
申请日：2008-02-25
Applicant: Dale B. Schenk , Eliezar Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
Inventor： Dale B. Schenk , Eliezar Masliah , Manuel J. Buttini , Tamie J. Chilcote , Edward Rockenstein , Kate Dora Games
IPC: A61K39/395
CPC classification number: C07K16/18 , A61K39/0007 , A61K2039/505 , A61K2039/55566 , A61K2039/6056 , C07K2317/34 , C07K2317/77 , C07K2317/80
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
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10.发明申请公开(公告)号：US20100086545A1
公开(公告)日：2010-04-08
申请号：US12528439
申请日：2008-02-22
Applicant: Dale B. Schenk , Eliezer Masliah , Manuel J. Buttini , Chilcote J. Tamie , Edward Rockenstein , Kate Dora Games
Inventor： Dale B. Schenk , Eliezer Masliah , Manuel J. Buttini , Chilcote J. Tamie , Edward Rockenstein , Kate Dora Games
IPC: A61K39/395 , C07K16/00 , C12P21/08 , C12N5/16 , A61P25/28
CPC classification number: C07K16/18 , A61K39/0007 , A61K2039/505 , A61K2039/55566 , C07K2317/21 , C07K2317/34 , C07K2317/92
Abstract: The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
Abstract translation: 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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