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公开(公告)号：US09067981B1
公开(公告)日：2015-06-30
申请号：US12608869
申请日：2009-10-29
Applicant: Guriqbal Basi , Dale B. Schenk , Hadar Hana Feinberg , William I. Weis
Inventor： Guriqbal Basi , Dale B. Schenk , Hadar Hana Feinberg , William I. Weis
IPC: C07K16/18 , A61K39/395
CPC classification number: C07K16/18 , A61K39/3955 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/60
Abstract: The present invention provides crystals including amino acids 1-7 of SEQ ID NO:1 and a Fab fragment of 12A11, 12B4, 10D5 or 3D6, as well as of amino acids 1-40 of SEQ ID NO:1 and a Fab fragment of 12A11 or 3D6, as well as methods for preparing the crystals. The present invention also provides a computer implemented method for analyzing binding of a candidate antibody fragment to a peptide including an epitope of amino acids 1-7 of SEQ ID NO:1, a method for identifying an antibody fragment that can mimic the Fab fragment of 12A11, a method for identifying an antibody fragment that can mimic the Fab fragment of 3D6, a method for identifying a candidate antibody fragment that binds to a peptide including an epitope of amino acids 1-7 of SEQ ID NO:1, and a method for designing a humanized antibody that binds to a peptide comprising an epitope of amino acids 1-7 of SEQ ID NO:1.
Abstract translation: 本发明提供了包含SEQ ID NO：1的氨基酸1-7和12A11,12B4,10D5或3D6的Fab片段以及SEQ ID NO：1的氨基酸1-40的晶体和包含SEQ ID NO： 12A11或3D6，以及制备晶体的方法。 本发明还提供了一种用于分析候选抗体片段与包含SEQ ID NO：1的氨基酸1-7的表位的肽的结合的计算机实施方法，用于鉴定可以模拟SEQ ID NO：1的Fab片段的抗体片段的方法 12A11，鉴定可以模拟3D6的Fab片段的抗体片段的方法，鉴定与包含SEQ ID NO：1的氨基酸1-7的表位的肽结合的候选抗体片段的方法，以及方法 用于设计与包含SEQ ID NO：1的氨基酸1-7的表位的肽结合的人源化抗体。
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公开(公告)号：US08791243B2
公开(公告)日：2014-07-29
申请号：US12811049
申请日：2008-12-29
Applicant: Dale B. Schenk , Peter A. Seubert , Jonathan Wall , Jose Saldanha
Inventor： Dale B. Schenk , Peter A. Seubert , Jonathan Wall , Jose Saldanha
IPC: C07K16/18 , A61K39/395 , C12N5/07
CPC classification number: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
Abstract translation: 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US08741298B2
公开(公告)日：2014-06-03
申请号：US13368260
申请日：2012-02-07
Applicant: Dale B. Schenk , Tarlochan S. Nijjar , Philip W. Payne , Robin Barbour
Inventor： Dale B. Schenk , Tarlochan S. Nijjar , Philip W. Payne , Robin Barbour
CPC classification number: C07K16/18 , A61K39/00 , C07K14/775 , C07K2317/24 , G01N33/6896 , G01N2333/775 , G01N2800/2821
Abstract: The present invention provides antibodies that preferentially bind to an ApoE(1-272) fragment relative to ApoE(1-299). These antibodies serve to reduce the toxicity of this fragment and find use in treatment and prophylaxis of a variety of neurological diseases.
Abstract translation: 本发明提供了相对于ApoE（1-299）优先结合ApoE（1-272）片段的抗体。 这些抗体用于降低该片段的毒性，可用于治疗和预防各种神经疾病。
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公开(公告)号：US08404815B2
公开(公告)日：2013-03-26
申请号：US13032412
申请日：2011-02-22
Applicant: Dale B. Schenk , Peter A. Seubert
Inventor： Dale B. Schenk , Peter A. Seubert
CPC classification number: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
Abstract translation: 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US20120321555A1
公开(公告)日：2012-12-20
申请号：US13460622
申请日：2012-04-30
Applicant: Dale B. SCHENK , Peter A. Seubert , Jonathan Wall , José W. Saldanha
Inventor： Dale B. SCHENK , Peter A. Seubert , Jonathan Wall , José W. Saldanha
CPC classification number: A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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公开(公告)号：US08268973B2
公开(公告)日：2012-09-18
申请号：US13187093
申请日：2011-07-20
Applicant: Dale B. Schenk , Peter A. Seubert , José Saldanha
Inventor： Dale B. Schenk , Peter A. Seubert , José Saldanha
CPC classification number: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
Abstract translation: 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US20110306756A1
公开(公告)日：2011-12-15
申请号：US12977013
申请日：2010-12-22
Applicant: Dale B. Schenk
Inventor： Dale B. Schenk
IPC: C07K16/18
CPC classification number: C07K14/4711 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0005 , A61K39/0007 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K16/18 , C07K2317/34 , C07K2317/70 , C07K2317/77 , C07K2319/00 , G01N2800/2821 , Y02A50/412 , A61K2300/00
Abstract: The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide, active fragments thereof or an antibody thereto.
Abstract translation: 本发明提供了治疗淀粉样变性疾病的组合物和方法。 这样的方法需要施用一种诱导针对患者淀粉样沉积物的有益免疫应答的药剂。 该方法对阿尔茨海默病的预防和治疗特别有用。 在这种方法中，合适的试剂是A＆bgr; 肽，其活性片段或其抗体。
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公开(公告)号：US08034348B2
公开(公告)日：2011-10-11
申请号：US11842113
申请日：2007-08-20
Applicant: Dale B. Schenk , Nicki Vasquez , Theodore Yednock
Inventor： Dale B. Schenk , Nicki Vasquez , Theodore Yednock
IPC: A61K39/385 , A61K39/39 , A61K38/08 , A61K39/05
CPC classification number: C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , Y02A50/472 , A61K2300/00
Abstract: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
Abstract translation: 本发明提供用于治疗与淀粉样蛋白沉积相关的疾病的改进剂和方法。 在病人的大脑中。 这样的方法需要对淀粉样蛋白沉积物诱导有益的免疫原性应答的施用试剂。 该方法可用于预防和治疗阿尔茨海默氏病。 优选的试剂包括A末端的N末端片段; 和结合相同的抗体。
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公开(公告)号：US07928203B2
公开(公告)日：2011-04-19
申请号：US12345650
申请日：2008-12-29
Applicant: Dale B. Schenk , Peter A. Seubert , Jonathan Wall , José W. Saldanha
Inventor： Dale B. Schenk , Peter A. Seubert , Jonathan Wall , José W. Saldanha
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
Abstract translation: 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US07893214B2
公开(公告)日：2011-02-22
申请号：US11842023
申请日：2007-08-20
Applicant: Dale B. Schenk
Inventor： Dale B. Schenk
IPC: C07K16/00
CPC classification number: C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K39/3955 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/77 , C07K2317/92 , C07K2319/00 , A61K2300/00
Abstract: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.
Abstract translation: 本发明提供用于治疗与淀粉样蛋白沉积相关的疾病的改进剂和方法。 在病人的大脑中。 优选的试剂包括人源化抗体。
