公开(公告)号：US5371086A

公开(公告)日：1994-12-06

申请号：US53869

申请日：1993-04-29

申请人： Tadahiro Takemoto ,  Masahiro Eda ,  Mitsuyoshi Hihara ,  Takehiro Okada ,  Hiroshi Sakashita ,  Miyuki Eiraku ,  Chikara Fukaya ,  Norifumi Nakamura ,  Masanori Sugiura ,  Sumio Matzno ,  Maki Goda ,  Yasumi Uchida

发明人： Tadahiro Takemoto ,  Masahiro Eda ,  Mitsuyoshi Hihara ,  Takehiro Okada ,  Hiroshi Sakashita ,  Miyuki Eiraku ,  Chikara Fukaya ,  Norifumi Nakamura ,  Masanori Sugiura ,  Sumio Matzno ,  Maki Goda ,  Yasumi Uchida

IPC分类号： C07D213/75 ,  C07D213/76 ,  C07D213/77 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D405/12 ,  C07D413/12 ,  A61K31/495 ,  A61K31/54 ,  C07D211/56 ,  C07D401/00

CPC分类号： C07D213/75 ,  C07D213/76 ,  C07D213/77 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D405/12 ,  C07D413/10

摘要： An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents .dbd.S, .dbd.NCN or .dbd.CHNO.sub.2 ; R.sub.1 represents --NR.sub.3 R.sub.4, --NHNR.sub.3 R.sub.4, --NHCONHR.sub.3 or --NHSO.sub.2 R.sub.3 ; R.sub.2 represents H, or substituted or unsubstituted alkyl; R.sub.3 and R.sub.4, which may be the same or different, represent H, substituted or unsubstituted alkyl, aryl, substituted or unsubstituted acyl or alkoxycarbonyl group; and R.sub.3 and R.sub.4 may form a heterocyclic ring together with a nitrogen atom to which R.sub.3 and R.sub.4 are bound, through another heteroatom or without it; an optical isomer thereof or art acid salt thereof, which is excellent in pharmacological effect and repressed in side effects as a drug for circulatory diseases.

摘要翻译： 由下式表示的氨基吡啶化合物：其中n表示0或1; Z表示= S，= NCN或= CHNO2; R 1表示-NR 3 R 4，-NHNR 3 R 4，-NHCONHR 3或-NHSO 2 R 3; R 2表示H或取代或未取代的烷基; R 3和R 4可以相同或不同，表示H，取代或未取代的烷基，芳基，取代或未取代的酰基或烷氧基羰基; 并且R 3和R 4可以与R3和R4连接的氮原子一起通过另一个杂原子或不与其形成杂环; 其光学异构体或其酸性盐，其药理作用优异，作为循环系统疾病药物的副作用被抑制。

公开(公告)号：US5262415A

公开(公告)日：1993-11-16

申请号：US850817

申请日：1992-03-13

申请人： Tadahiro Takemoto ,  Masahiro Eda ,  Mitsuyoshi Hihara ,  Takehiro Okada ,  Hiroshi Sakashita ,  Miyuki Eiraku ,  Chikara Fukaya ,  Norifumi Nakamura ,  Masanori Sugiura ,  Sumio Matzno ,  Maki Goda ,  Yasumi Uchida

发明人： Tadahiro Takemoto ,  Masahiro Eda ,  Mitsuyoshi Hihara ,  Takehiro Okada ,  Hiroshi Sakashita ,  Miyuki Eiraku ,  Chikara Fukaya ,  Norifumi Nakamura ,  Masanori Sugiura ,  Sumio Matzno ,  Maki Goda ,  Yasumi Uchida

IPC分类号： A61K31/44 ,  A61K31/4406 ,  A61K31/4427 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D213/75 ,  C07D213/76 ,  C07D213/77 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  A61K31/54 ,  C07D211/56 ,  C07D211/72 ,  C07D401/00

CPC分类号： C07D213/75 ,  C07D213/76 ,  C07D213/77 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D405/12 ,  C07D413/10

摘要： An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents .dbd.S, .dbd.O, .dbd.NCN or .dbd.CHNO.sub.2 ; R.sub.1 represents --CN, --NR.sub.3 R.sub.4, --CONR.sub.3 R.sub.4, --NHNR.sub.3 R.sub.4, --NHCONHR.sub.3, --NHSO.sub.2 R.sub.3 or --SR.sub.3 ; R.sub.2 represents H, or substituted or unsubstituted alkyl; R.sub.3 and R.sub.4, which may be the same or different, represent H, substituted or unsubstituted alkyl, aryl, substituted or unsubstituted acyl or alkoxycarbonyl group; and R.sub.3 and R.sub.4 may form a heterocyclic ring together with a nitrogen atom to which R.sub.3 and R.sub.4 are bound, through another heteroatom or without it; or an acid salt thereof, which is excellent in pharmacological effect and repressed in side effects as a drug for circulatory diseases.