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1.发明授权Immunogenic compositions in particulate form and methods for producing the same 有权颗粒形式的免疫原性组合物及其制备方法公开(公告)号：US09585953B2
公开(公告)日：2017-03-07
申请号：US14006121
申请日：2012-03-22
申请人： Cornelis Johannes Leenhouts , Bert Jan Haijema , Maarten Leonardus van Roosmalen , Petrus Josephus Marie Rottier , Cornelis Alexander Maria de Haan , Berend Jan Bosch
发明人： Cornelis Johannes Leenhouts , Bert Jan Haijema , Maarten Leonardus van Roosmalen , Petrus Josephus Marie Rottier , Cornelis Alexander Maria de Haan , Berend Jan Bosch
IPC分类号： A61K39/385 , A61K39/145 , A61K39/155 , C07K14/005 , A61K47/48 , C12N9/36 , A61K39/12 , A61K39/00
CPC分类号： A61K39/385 , A61K39/12 , A61K39/145 , A61K39/155 , A61K47/646 , A61K2039/543 , A61K2039/55505 , A61K2039/6068 , C07K14/005 , C07K2319/20 , C07K2319/33 , C07K2319/40 , C07K2319/70 , C07K2319/73 , C12N9/2462 , C12N2760/16122 , C12N2760/16134 , C12N2760/18522 , C12N2760/18534 , C12Y302/01017
摘要： The invention relates to the field of immunology and vaccine development, in particular to the development of vaccines based on native antigen oligomers. Provided is an immunogenic composition in particulate form, comprising oligomers of a surface exposed polypeptide of pathogenic origin or tumor origin, or antigenic part thereof, said oligomers being bound non-covalently to a particulate carrier, and a pharmaceutically acceptable diluent or excipient. Also provided is a recombinant polypeptide comprising (A) an N- or C-terminal antigenic domain, comprising at least one surface exposed polypeptide of pathogenic or tumor origin, or antigenic part thereof, the antigenic domain being fused to (B) an oligomerization domain (OMD), said oligomerization domain being fused via (C) a linker domain to (D) a peptidoglycan binding domain (PBD) consisting of a single copy of a LysM domain capable of mediating the non-covalent attachment of the polypeptide to a non-viable bacterium-like particle (BLP) obtained from a Gram-positive bacterium.
摘要翻译： 本发明涉及免疫学和疫苗开发领域，特别涉及基于天然抗原寡聚体的疫苗的开发。 本发明提供了一种颗粒形式的免疫原性组合物，其包含病原起源或肿瘤来源的表面暴露多肽的寡聚体或其抗原部分，所述寡聚物非共价结合至颗粒状载体，以及药学上可接受的稀释剂或赋形剂。 还提供了包含（A）N-或C-末端抗原结构域的重组多肽，其包含至少一种表面暴露的病原性或肿瘤来源的多肽或其抗原部分，所述抗原结构域与（B）寡聚化结构域 （OMD），所述寡聚结构域通过（C）连接体结构域融合到（D）由能够将多肽非共价连接到非非共价连接的LysM结构域的单拷贝组成的肽聚糖结合结构域（PBD） 从革兰氏阳性菌获得的可行的细菌样颗粒（BLP）。
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2.发明申请Immunogenic Compositions In Particulate Form And Methods For Producing The Same 有权颗粒形式的免疫原性组合物及其生产方法公开(公告)号：US20140093532A1
公开(公告)日：2014-04-03
申请号：US14006121
申请日：2012-03-22
申请人： Cornelis Johannes Leenhouts , Bert Jan Haijema , Maarten Leonardus Van Roosmalen , Petrus Josephus Marie Rottier , Cornelis Alexander Maria De Haan , Berend Jan Bosch
发明人： Cornelis Johannes Leenhouts , Bert Jan Haijema , Maarten Leonardus Van Roosmalen , Petrus Josephus Marie Rottier , Cornelis Alexander Maria De Haan , Berend Jan Bosch
IPC分类号： A61K39/385 , C07K14/005 , A61K47/48
CPC分类号： A61K39/385 , A61K39/12 , A61K39/145 , A61K39/155 , A61K47/646 , A61K2039/543 , A61K2039/55505 , A61K2039/6068 , C07K14/005 , C07K2319/20 , C07K2319/33 , C07K2319/40 , C07K2319/70 , C07K2319/73 , C12N9/2462 , C12N2760/16122 , C12N2760/16134 , C12N2760/18522 , C12N2760/18534 , C12Y302/01017
摘要： The invention relates to the field of immunology and vaccine development, in particular to the development of vaccines based on native antigen oligomers. Provided is an immunogenic composition in particulate form, comprising oligomers of a surface exposed polypeptide of pathogenic origin or tumour origin, or antigenic part thereof, said oligomers being bound non-covalently to a particulate carrier, and a pharmaceutically acceptable diluent or excipient. Also provided is a recombinant polypeptide comprising (A) an N- or C-terminal antigenic domain, comprising at least one surface exposed polypeptide of pathogenic or tumour origin, or antigenic part thereof, the antigenic domain being fused to (B) an oligomerization domain (OMD), said oligomerization domain being fused via (C) a linker domain to (D) a peptidoglycan binding domain (PBD) consisting of a single copy of a LysM domain capable of mediating the non-covalent attachment of the polypeptide to a non-viable bacterium-like particle (BLP) obtained from a Gram-positive bacterium.
摘要翻译： 本发明涉及免疫学和疫苗开发领域，特别涉及基于天然抗原寡聚体的疫苗的开发。 本发明提供了一种颗粒形式的免疫原性组合物，其包含病原起源或肿瘤来源的表面暴露多肽的寡聚体或其抗原部分，所述寡聚物非共价结合至颗粒状载体，以及药学上可接受的稀释剂或赋形剂。 还提供了包含（A）N-或C-末端抗原结构域的重组多肽，其包含至少一种表面暴露的病原性或肿瘤来源的多肽或其抗原部分，所述抗原结构域与（B）寡聚化结构域 （OMD），所述寡聚结构域通过（C）连接体结构域融合到（D）由能够将多肽非共价连接到非非共价连接的LysM结构域的单拷贝组成的肽聚糖结合结构域（PBD） 从革兰氏阳性菌获得的可行的细菌样颗粒（BLP）。
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公开(公告)号：US09011870B2
公开(公告)日：2015-04-21
申请号：US11989118
申请日：2006-07-20
IPC分类号： A61K39/385 , C07K14/335 , A61K39/00
CPC分类号： A61K47/48369 , A61K39/385 , A61K47/68 , A61K2039/541 , A61K2039/55555 , A61K2039/6056 , A61K2039/6068 , A61K2039/622 , C07K14/335 , C07K16/18 , C07K2319/70 , C07K2319/705
摘要： The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
摘要翻译： 本发明涉及免疫学和疫苗递送领域。 更具体地说，本发明涉及具有内在免疫刺激性质的细菌疫苗递送技术，其允许固定目的抗原，而无需先前的抗原修饰。 本发明提供了一种抗原负载的免疫原性载体复合物，其包含至少一个与免疫原性载体连接的双功能多肽，所述双功能多肽包含肽聚糖结合结构域（PBD），多肽与所述载体连接，融合至抗原结合结构域 ），至少一种目标抗原结合于该抗原。 还提供了包含本发明的抗原负载的免疫原性载体复合物的药物（例如疫苗）组合物。
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公开(公告)号：US20090263414A1
公开(公告)日：2009-10-22
申请号：US11989118
申请日：2006-07-20
IPC分类号： A61K39/385 , C07K14/00
CPC分类号： A61K47/48369 , A61K39/385 , A61K47/68 , A61K2039/541 , A61K2039/55555 , A61K2039/6056 , A61K2039/6068 , A61K2039/622 , C07K14/335 , C07K16/18 , C07K2319/70 , C07K2319/705
摘要： The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
摘要翻译： 本发明涉及免疫学和疫苗递送领域。 更具体地说，本发明涉及具有内在免疫刺激性质的细菌疫苗递送技术，其允许固定目的抗原，而无需先前的抗原修饰。 本发明提供了一种抗原负载的免疫原性载体复合物，其包含至少一个与免疫原性载体连接的双功能多肽，所述双功能多肽包含肽聚糖结合结构域（PBD），多肽与所述载体连接，融合至抗原结合结构域 ），至少一种目标抗原结合于该抗原。 还提供了包含本发明的抗原负载的免疫原性载体复合物的药物（例如疫苗）组合物。
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5.发明申请公开(公告)号：US20110044982A1
公开(公告)日：2011-02-24
申请号：US12989886
申请日：2009-09-22
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12N5/10 , A61P37/04
CPC分类号： C07K16/1018 , A61K39/00 , A61K2039/6068 , C07K14/005 , C07K2317/22 , C07K2317/622 , C07K2319/00 , C12N2760/16122 , C12N2760/16222
摘要： The invention relates to the field of immunology and vaccines. In particular, it relates to proteinaceous substances and the uses thereof in vaccines against infections caused by respiratory pathogens.
摘要翻译： 本发明涉及免疫学和疫苗领域。 特别涉及蛋白质物质及其在抗呼吸道病原体感染疫苗中的应用。
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