公开(公告)号：US20210186728A1

公开(公告)日：2021-06-24

申请号：US17192310

申请日：2021-03-04

Applicant: Lyra Therapeutics, Inc.

Inventor： Jon Merlo ,  Lee Core ,  Garrett Prahl ,  Travis White ,  Bryan Goh ,  Randy Beyreis

IPC: A61F2/95 ,  A61F2/966

Abstract: This disclosure pertains, inter alia, to scaffold loading and delivery devices, assemblies, systems and methods of using the same.

公开(公告)号：US10973664B2

公开(公告)日：2021-04-13

申请号：US15376842

申请日：2016-12-13

Applicant: Lyra Therapeutics, Inc.

Inventor： Jon Merlo ,  Lee Core ,  Garrett Prahl ,  Travis White ,  Bryan Goh ,  Randy Beyreis

IPC: A61F2/95 ,  A61F2/966

Abstract: This disclosure pertains, inter alia, to scaffold loading and delivery devices, assemblies, systems and methods of using the same.

公开(公告)号：US20200316253A1

公开(公告)日：2020-10-08

申请号：US16839832

申请日：2020-04-03

Applicant: LYRA THERAPEUTICS, INC.

Inventor： Changcheng You ,  Quynh Pham ,  Danny Concagh

IPC: A61L27/34 ,  A61M25/10 ,  A61M31/00 ,  A61L27/54 ,  A61K31/58 ,  A61L27/58 ,  A61L27/18 ,  A61L27/56 ,  A61F2/18 ,  A61F2/90

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.

公开(公告)号：US12036337B2

公开(公告)日：2024-07-16

申请号：US18099738

申请日：2023-01-20

Applicant: LYRA THERAPEUTICS, INC.

Inventor： Changcheng You ,  Quynh Pham ,  Danny Concagh

IPC: A61L27/34 ,  A61F2/18 ,  A61F2/90 ,  A61K31/58 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61M25/10 ,  A61M31/00

CPC classification number: A61L27/34 ,  A61F2/186 ,  A61F2/90 ,  A61K31/58 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61M25/10 ,  A61M31/002 ,  A61F2210/0004 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/604 ,  A61L2300/608 ,  A61M2025/105 ,  A61M2210/0681 ,  A61L27/18 ,  C08L67/02 ,  A61L27/34 ,  C08L67/02

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. The present disclosure describes various sinus scaffolds having fiber-based and non-fiber-based designs. These designs vary in form, dimension, and delivery location. In addition, therapeutic agent(s) may optionally be included within the scaffolds for local delivery over a brief or extended period of time. Therefore, these scaffolds may be used to improve sinus patency, for example, in surgically modified sinus spaces or in sinus spaces that have not previously undergone surgical modification. Moreover, these scaffolds may be used to deliver local therapeutic agent(s) to such sinus spaces, including, for instance, as part of a treatment program that is an alternative to sinus surgery (e.g., FESS) or in other instances as part of a postoperative care of FESS in some embodiments.

公开(公告)号：US10857013B2

公开(公告)日：2020-12-08

申请号：US16180452

申请日：2018-11-05

Applicant: Lyra Therapeutics, Inc.

Inventor： Marc Helmick ,  Jonathan Merlo ,  Lee Core ,  Quyhn Pham ,  Anthony Prostrollo ,  Ross Paulson ,  Danielle Peterson ,  Garrett Prahl ,  Randall Beyreis ,  Michele Chouinard

IPC: A61F2/95 ,  A61F2/18 ,  A61F2/958 ,  A61F2/966 ,  A61F2/90

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used for loading scaffolds into delivery devices and delivery of scaffolds into the body of a patient, including delivery of scaffolds to the sinuses for the treatment of chronic sinusitis, among other purposes.

公开(公告)号：US10806568B2

公开(公告)日：2020-10-20

申请号：US16199670

申请日：2018-11-26

Applicant: Lyra Therapeutics, Inc.

Inventor： Changcheng You ,  Quynh Pham ,  Danny Concagh

IPC: A61F2/18 ,  A61L27/18 ,  A61L27/56 ,  A61F2/90 ,  A61L31/06 ,  A61L31/10 ,  A61K31/58 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54

Abstract: This disclosure describes various sinus scaffolds having fiber-based and non-fiber based designs, materials, devices, kits and methods that may be used to treat chronic sinusitis. These designs vary in form, dimension, and delivery location (i.e. maxillary, frontal, ethmoidal, sphenoidal sinuses, and middle meatus). In addition therapeutic agent(s) may optionally be included within the scaffolds for local delivery over a brief or extended period of time.

公开(公告)号：US20240408273A1

公开(公告)日：2024-12-12

申请号：US18810072

申请日：2024-08-20

Applicant: Lyra Therapeutics, Inc.

Inventor： Changcheng You ,  Quynh Pham ,  Danny Concagh

IPC: A61L27/34 ,  A61F2/18 ,  A61F2/90 ,  A61K31/58 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61M25/10 ,  A61M31/00

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. An implant is configured to fit inside of the middle meatus of a human nasal cavity. The implant includes a therapeutic-agent formulation containing a layer of over 2000 micrograms of mometasone furoate. The implant releases the mometasone furoate for more than 12 weeks. A second implant can also be provided configured to fit inside the middle meatus. The second implant also includes a therapeutic-agent formulation containing a layer of over 2000 micrograms of mometasone furoate, and releases the mometasone furoate for more than 12 weeks.

公开(公告)号：US20240269350A1

公开(公告)日：2024-08-15

申请号：US18615515

申请日：2024-03-25

Applicant: LYRA THERAPEUTICS, INC.

Inventor： Danny Concagh ,  Changcheng You ,  Maria Palasis ,  Allison Gartung

IPC: A61L27/54

CPC classification number: A61L27/54 ,  A61L2300/204

Abstract: The present invention is related to the fields of drug delivery and implantable devices. Devices, systems, and methods for use of drug delivery implants are contemplated herein. The present invention relates to implantable devices, as well as their methods of use and manufacturing. Exemplary embodiments of the present invention include fiber and sheet based implantable devices for drug delivery to bodily lumens. In particular, implantable drug delivery device compositions are contemplated for use providing consistent drug delivery over time to the central nervous system for treating associated disorders and disease. As one specific example, a CNS delivery device is contemplated for implantation in a region of the nose for providing consistent drug delivery over time to brain tissue for treating brain associated diseases, e.g. Alzheimer's disease (AD) and related dementias (AD/ADRD).

公开(公告)号：US20230233451A1

公开(公告)日：2023-07-27

申请号：US18127214

申请日：2023-03-28

Applicant: LYRA THERAPEUTICS, INC.

Inventor： Maria Palasis ,  Danny Concagh ,  Changcheng You

IPC: A61K9/00 ,  A61K31/58

CPC classification number: A61K9/0004 ,  A61K9/0043 ,  A61K31/58

Abstract: The present invention relates to implantable devices, as well as their methods of use and manufacturing, having osmotic capabilities. Exemplary embodiments of the present invention include fiber and sheet based implantable devices for drug delivery to bodily lumens.

公开(公告)号：US20230149601A1

公开(公告)日：2023-05-18

申请号：US18099738

申请日：2023-01-20

Applicant: LYRA THERAPEUTICS, INC.

Inventor： Changcheng You ,  Quynh Pham ,  Danny Concagh

IPC: A61L27/34 ,  A61M25/10 ,  A61M31/00 ,  A61L27/54 ,  A61K31/58 ,  A61L27/58 ,  A61L27/18 ,  A61L27/56 ,  A61F2/18 ,  A61F2/90

CPC classification number: A61L27/34 ,  A61M25/10 ,  A61M31/002 ,  A61L27/54 ,  A61K31/58 ,  A61L27/58 ,  A61L27/18 ,  A61L27/56 ,  A61F2/186 ,  A61F2/90 ,  A61M2025/105 ,  A61F2250/0067 ,  A61M2210/0681 ,  A61L2300/41 ,  A61F2250/0031 ,  A61L2300/222 ,  A61L2300/604 ,  A61L2300/608 ,  A61F2210/0004

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.