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公开(公告)号：US09539374B2
公开(公告)日：2017-01-10
申请号：US12778710
申请日：2010-05-12
申请人： Lise N. Halpern , Tim Costello , Jonathan White
发明人： Lise N. Halpern , Tim Costello , Jonathan White
CPC分类号： A61M1/02 , A61M2205/6054 , A61M2205/6063 , A61M2205/6072 , A61M2209/06 , B01L3/5453 , B01L9/54
摘要： A donated blood collection kit includes an easy-to-open closed container. Stored within the container are items necessary or useful for collecting donated blood, such as an antiseptic scrub, an antiseptic swab, test tubes, a blood collection container, a gauze pad and a sheet of pre-printed adhesive barcode labels. Each kit is assigned a unique identification when the kit is manufactured. The identification may eventually be used as the unique donor identification for a unit of donated blood that is collected using the items in the kit. The container is pre-labeled with the unique identification, such as by a barcode or an RF-ID tag. The test tubes and, if included, the blood collection container are pre-labeled with the same unique donor identification. The adhesive barcode labels in the container are pre-printed with the same unique donor identification and may be affixed to items that are not provided in the kit but, nonetheless, should be associated with the unit of blood that may be collected using the kit. Information about lot numbers and expiration dates for the items in the kit may be encoded in the kit's unique identification and/or stored in a database in association with the kit's identification.
摘要翻译： 捐赠的血液收集套件包括一个易于打开的密闭容器。 储存在容器内的是用于收集捐赠血液的必需或有用的物品，例如消毒洗涤剂，防腐拭剂，试管，采血容器，纱布垫和预先印刷的粘合剂条形码标签片。 当套件被制造时，每个套件被分配一个唯一的标识。 该鉴定可能最终被用作使用试剂盒中的物品收集的捐赠血液单位的唯一捐赠者身份。 容器被预先标记有唯一标识，例如通过条形码或RF-ID标签。 试管和（如果包括的话）采血容器用相同的独特供体标识物进行预标记。 容器中的粘合剂条形码标签被预先印有相同的独特的供体标识，并且可以粘贴在试剂盒中未提供的物品上，但仍应与使用试剂盒收集的血液单位相关。 关于套件中项目的批号和有效期的信息可以编码成套件的唯一标识和/或与套件标识相关联的数据库中。
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公开(公告)号：US06641552B1
公开(公告)日：2003-11-04
申请号：US09494848
申请日：2000-02-01
IPC分类号： A61M3700
CPC分类号： B04B5/0428 , A61M1/0009 , A61M1/0011 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M5/1483 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , B04B5/0442
摘要： A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner.
摘要翻译： 一个足够紧凑的系统，可以完全位于捐赠者的椅子旁边，并且能够在捐赠者献血后仍然在椅子上休息时处理血液。 分离的血液成分（血浆和红细胞）可以在全血抽取之后立即储存在其各自的最佳环境中，并且血液不需要被运回到分离实验室进行处理。 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液之后保持血液的转子（2a）和马达（50） 用于旋转转子以使血液分离成组分，例如血浆和红细胞。 在一个优选的实施方式中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在将血浆从红色 血细胞和用于存储分离的红细胞的第二容器（91）。 该系统还包括管（73），其可以具有内置在其中的阀（81）并且可以在外部作用，以便以期望的方式引导血液成分。
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公开(公告)号：US6007509A
公开(公告)日：1999-12-28
申请号：US835680
申请日：1997-04-09
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner.
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公开(公告)号：US5779660A
公开(公告)日：1998-07-14
申请号：US662615
申请日：1996-06-13
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner.
摘要翻译： 一个足够紧凑的系统，可以完全位于捐赠者的椅子旁边，并且能够在捐赠者献血后仍然在椅子上休息时处理血液。 分离的血液成分（血浆和红细胞）可以在全血抽取之后立即储存在其各自的最佳环境中，并且血液不需要被运回到分离实验室进行处理。 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液之后保持血液的转子（2a）和马达（50） 用于旋转转子以使血液分离成组分，例如血浆和红细胞。 该系统还提供用于收集分离的部件的容器。 在一个优选的实施方式中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在将血浆从红色 血细胞和用于存储分离的红细胞的第二容器（91）。 该系统还包括管（73），其可以具有内置在其中的阀（81）并且可以在外部作用，以便以期望的方式引导血液成分。
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公开(公告)号：US5728060A
公开(公告)日：1998-03-17
申请号：US662617
申请日：1996-06-13
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system for collecting and processing blood from a donor (70), wherein the system may be compact enough to be located entirely beside the donor's chair, and be able to process the blood while the donor is still resting in the chair after having donated the blood. Thus, the separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately alter the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a variable-volume rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner. The tubing connects the needle (72), the rotor (2a), and the first and second containers (92, 91). With the valving, the tubing is able to permit (i) the flow of whole blood from the needle (72) to the rotor (2a), (ii) the flow of anticoagulant from the first container (92) to the whole blood flowing from the needle to the rotor, (iii) the flow of plasma from the rotor to the first container, and (iv) the flow of red blood cells from the rotor to the second container (91). The motor (50) and the valving are preferably controlled by an electronic controller. Preferably, the system also includes a pump (61), which is also controlled by the controller, and which forces the blood components out of the rotor (2a) to the tubing. The pump is preferably able to draw the whole blood into the rotor.
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6.发明授权Simplified method for the preparation of human lymphokine activated killer cells 失效用于制备人淋巴因子活化的杀伤细胞的简化方法
公开(公告)号：US4808151A
公开(公告)日：1989-02-28
申请号：US42998
申请日：1987-04-27
IPC分类号： A61K35/12 , A61K35/14 , A61K35/18 , C12N5/00 , C12N5/02 , C12N5/0783 , A61M37/00 , A61K37/02 , A61K45/05
CPC分类号： A61K35/17 , C12N5/0087 , C12N5/0636 , A61K2035/124 , C12N2500/32 , C12N2501/23
摘要： A lymphocyte-containing white blood cell fraction obtained by standard leukapheresis, elutriation leukapheresis or standard centrifugation can be used for production of lymphokine activated killer cells by incubation with IL-2. Removal of red blood cells and granulocytes by centrifugation on ficoll is not necessary.
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公开(公告)号：US06379322B1
公开(公告)日：2002-04-30
申请号：US09027072
申请日：1998-02-20
IPC分类号： A61M3700
CPC分类号： B04B5/0428 , A61M1/0009 , A61M1/0011 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M5/1483 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , B04B5/0442
摘要： A system for collecting and processing blood from a donor (70), wherein the system may be compact enough to be located entirely beside the donor's chair, and be able to process the blood while the donor is still resting in the chair after having donated the blood. Thus, the separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a variable-volume rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner.
摘要翻译： 一种用于从供体（70）收集和处理血液的系统，其中所述系统可以足够紧凑以完全位于供体椅子旁边，并且在捐赠者在捐赠者之后仍然休息在椅子中时能够处理血液 血液。 因此，分离的血液成分（血浆和红细胞）可以在全血抽取之后立即存储在其各自的最佳环境中，并且血液不需要被运回到分离实验室进行处理。 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液后保持血液的可变体积转子（2a） （50），用于使转子旋转以使血液分离成组分，例如血浆和红细胞。 该系统还提供用于收集分离的部件的容器。 在一个优选的实施方式中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在将血浆从红色 血细胞和用于存储分离的红细胞的第二容器（91）。 该系统还包括管（73），其可以具有内置在其中的阀（81）并且可以在外部作用，以便以期望的方式引导血液成分。
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公开(公告)号：US5651766A
公开(公告)日：1997-07-29
申请号：US482617
申请日：1995-06-07
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner. The tubing connects the needle (72), the rotor (2a), and the first and second containers (92, 91). With the valving, the tubing is able to permit (i) the flow of whole blood from the needle (72) to the rotor (2a), (ii) the flow of anticoagulant from the first container (92) to the whole blood flowing from the needle to the rotor, (iii) the flow of plasma from the rotor to the first container, and (iv) the flow of red blood cells from the rotor to the second container (91).
摘要翻译： 一个足够紧凑的系统，可以完全位于捐赠者的椅子旁边，并且能够在捐赠者献血后仍然在椅子上休息时处理血液。 分离的血液成分（血浆和红细胞）可以在全血抽取之后立即储存在其各自的最佳环境中，并且血液不需要被运回到分离实验室进行处理。 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液之后保持血液的转子（2a）和马达（50） 用于旋转转子以使血液分离成组分，例如血浆和红细胞。 该系统还提供用于收集分离的部件的容器。 在一个优选的实施方式中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在将血浆从红色 血细胞和用于存储分离的红细胞的第二容器（91）。 该系统还包括管（73），其可以具有内置在其中的阀（81）并且可以在外部作用，以便以期望的方式引导血液成分。 管连接针（72），转子（2a）以及第一和第二容器（92,91）。 通过阀门，管道能够允许（i）从针头（72）到转子（2a）的全血流动，（ii）抗凝血剂从第一容器（92）流到全血流动 （iii）从转子到第一容器的等离子体流动，以及（iv）红细胞从转子到第二容器（91）的流动。
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公开(公告)号：US20110281346A1
公开(公告)日：2011-11-17
申请号：US12778710
申请日：2010-05-12
申请人： Lise N. Halpern , Tim Costello , Jonathan White
发明人： Lise N. Halpern , Tim Costello , Jonathan White
CPC分类号： A61M1/02 , A61M2205/6054 , A61M2205/6063 , A61M2205/6072 , A61M2209/06 , B01L3/5453 , B01L9/54
摘要： A donated blood collection kit includes an easy-to-open closed container. Stored within the container are items necessary or useful for collecting donated blood, such as an antiseptic scrub, an antiseptic swab, test tubes, a blood collection container, a gauze pad and a sheet of pre-printed adhesive barcode labels. Each kit is assigned a unique identification when the kit is manufactured. The identification may eventually be used as the unique donor identification for a unit of donated blood that is collected using the items in the kit. The container is pre-labeled with the unique identification, such as by a barcode or an RF-ID tag. The test tubes and, if included, the blood collection container are pre-labeled with the same unique donor identification. The adhesive barcode labels in the container are pre-printed with the same unique donor identification and may be affixed to items that are not provided in the kit but, nonetheless, should be associated with the unit of blood that may be collected using the kit. Information about lot numbers and expiration dates for the items in the kit may be encoded in the kit's unique identification and/or stored in a database in association with the kit's identification.
摘要翻译： 捐赠的血液收集套件包括一个易于打开的密闭容器。 储存在容器内的是用于收集捐赠血液的必需或有用的物品，例如消毒洗涤剂，防腐拭剂，试管，采血容器，纱布垫和预先印刷的粘合剂条形码标签片。 当套件被制造时，每个套件被分配一个唯一的标识。 该鉴定可能最终被用作使用试剂盒中的物品收集的捐赠血液单位的唯一捐赠者身份。 容器被预先标记有唯一标识，例如通过条形码或RF-ID标签。 试管和（如果包括的话）采血容器用相同的独特供体标识物进行预标记。 容器中的粘合剂条形码标签被预先印有相同的独特的供体标识，并且可以粘贴在试剂盒中未提供的物品上，但仍应与使用试剂盒收集的血液单位相关。 关于套件中项目的批号和有效期的信息可以编码成套件的唯一标识和/或与套件标识相关联的数据库中。
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公开(公告)号：US6102883A
公开(公告)日：2000-08-15
申请号：US964177
申请日：1997-11-04
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells.
摘要翻译： 一个足够紧凑的系统，可以完全位于捐赠者的椅子旁边，并且能够在捐赠者献血后仍然在椅子上休息时处理血液。 分离的血液成分（血浆和红细胞）可以在全血抽取之后立即储存在其各自的最佳环境中，并且血液不需要被运回到分离实验室进行处理。 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液之后保持血液的转子（2a）和马达（50） 用于旋转转子以使血液分离成组分，例如血浆和红细胞。 该系统还提供用于收集分离的部件的容器。 在一个优选的实施方式中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在将血浆从红色 血细胞和用于存储分离的红细胞的第二容器（91）。
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