知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.024 秒)

    Fusion protein comprising tumor necrosis factor related apoptosis inducing ligand and integrin ligand and use thereof
    1.
    发明授权
    Fusion protein comprising tumor necrosis factor related apoptosis inducing ligand and integrin ligand and use thereof 有权
    包含肿瘤坏死因子相关凋亡诱导配体和整联蛋白配体的融合蛋白及其用途

    公开(公告)号：US09340596B2

    公开(公告)日：2016-05-17

    申请号：US12739003

    申请日：2008-10-08

    申请人： Zichun Hua ,  Lin Cao

    发明人： Zichun Hua ,  Lin Cao

    IPC分类号： C07K19/00 ,  C07K14/52 ,  C07K14/47 ,  C07K14/715 ,  A61K38/00

    CPC分类号： C07K14/4747 ,  A61K38/00 ,  C07K14/7151 ,  Y02A50/473

    摘要： Provided is a fusion protein comprising a tumor necrosis factor related apoptosis inducing ligand (TRAIL), integrin ligands of αVβ3 and αVβ5 and a linking peptide. Also provided are the expression method and simple separation and purification process for the production of the fusion protein which is soluble and has high content of the polymer, and use of the fusion protein for the manufacturing of a medicament for the treatment of tumor. The fusion protein has good tumor tissue targeting property, significantly enhanced anti-tumor effect, which can also reduce the dose of the needed protein for the target treatment effect, improve the bioavailability, reduce the treatment cost, decrease and overcome the potential toxic and side effects of the tumor necrosis factor-related apoptosis inducing ligand.

    摘要翻译： 提供了包含肿瘤坏死因子相关的凋亡诱导配体（TRAIL），αV＆bgr 3和αV＆bgr 5的整联蛋白配体和连接肽的融合蛋白。 还提供了用于生产可溶性且具有高含量聚合物的融合蛋白的表达方法和简单的分离和纯化方法，以及使用该融合蛋白来制备用于治疗肿瘤的药物。 融合蛋白具有良好的肿瘤组织靶向特性，显着增强抗肿瘤效果，也可以减少所需蛋白质的剂量用于目标治疗效果，提高生物利用度，降低治疗成本，降低和克服潜在毒性和副作用 肿瘤坏死因子相关凋亡诱导配体的作用。

    DYNAMIC GENERATION OF USER INTERFACE
    2.
    发明申请
    DYNAMIC GENERATION OF USER INTERFACE 审中-公开
    用户界面的动态生成

    公开(公告)号：US20150089403A1

    公开(公告)日：2015-03-26

    申请号：US14032196

    申请日：2013-09-20

    申请人： Jin You ZHU ,  Xiang CAI ,  Yan ZANG ,  Lin CAO

    发明人： Jin You ZHU ,  Xiang CAI ,  Yan ZANG ,  Lin CAO

    IPC分类号： G06F3/0484

    CPC分类号： G06F8/38

    摘要： Described herein is a technology to dynamically generate a user interface (UI). In one implementation, a data source is analyzed to determine field information of the data source. UI controls are mapped to fields of the data source based on the field information to generate UI control mapping information. Based on the field information and the UI control mapping information, a layout may be generated. The layout may then be presented for preview.

    摘要翻译： 这里描述了一种用于动态生成用户界面（UI）的技术。 在一个实现中，分析数据源以确定数据源的字段信息。 UI控件基于字段信息映射到数据源的字段，以生成UI控件映射信息。 基于场信息和UI控制映射信息，可以生成布局。 然后可以呈现布局以进行预览。

    PACKAGING AND DEPLOYING HYBRID APPLICATIONS
    3.
    发明申请
    PACKAGING AND DEPLOYING HYBRID APPLICATIONS 审中-公开
    包装和部署混合应用

    公开(公告)号：US20150082298A1

    公开(公告)日：2015-03-19

    申请号：US14032184

    申请日：2013-09-19

    申请人： Qiu Shi WANG ,  Lin CAO

    发明人： Qiu Shi WANG ,  Lin CAO

    IPC分类号： G06F9/445

    CPC分类号： G06F8/60

    摘要： Described herein is a technology to facilitate packaging and deployment of a hybrid application. In one implementation, one or more initial dependencies are identified from a configuration file associated with a hybrid application. Any issues associated with the initial dependencies may be resolved to generate one or more final dependencies. A package may be generated based on the one or more final dependencies and the hybrid application code. The package may then be deployed to a target device or device simulator.

    摘要翻译： 这里描述的是用于促进混合应用的包装和部署的技术。 在一个实现中，从与混合应用相关联的配置文件中识别一个或多个初始依赖性。 可能会解决与初始依赖关联的任何问题，以生成一个或多个最终依赖关系。 可以基于一个或多个最终依赖性和混合应用代码来生成包。 然后，该包可以被部署到目标设备或设备模拟器。

    AUTOMATIC DEPLOYMENT AND UPDATE OF HYBRID APPLICATIONS
    5.
    发明申请
    AUTOMATIC DEPLOYMENT AND UPDATE OF HYBRID APPLICATIONS 有权
    混合应用的自动部署和更新

    公开(公告)号：US20150347119A1

    公开(公告)日：2015-12-03

    申请号：US14294133

    申请日：2014-06-02

    申请人： Qiushi WANG ,  Lin CAO

    发明人： Qiushi WANG ,  Lin CAO

    IPC分类号： G06F9/445 ,  H04L29/08 ,  G06F17/30 ,  G06F9/44

    CPC分类号： G06F8/65 ,  G06F8/61 ,  G06F8/70 ,  G06F17/30153 ,  H04L67/34 ,  H04L69/04

    摘要： Described herein is a framework for deploying and updating applications (Apps). In accordance with one aspect, a source code of a hybrid application may be provided by a development environment running on a cloud server, in response to a user event. A deployment generator running on the cloud server may be automatically invoked to receive the source code of the hybrid application. The source code of the hybrid application may be further packaged to form a hybrid application package for deployment by the deployment generator. The hybrid application package may be deployed to a deployment service on the cloud server.

    摘要翻译： 这里描述的是用于部署和更新应用程序（Apps）的框架。 根据一个方面，响应于用户事件，混合应用的源代码可以由在云服务器上运行的开发环境提供。 可以自动调用在云服务器上运行的部署生成器来接收混合应用程序的源代码。 可以进一步打包混合应用的源代码以形成用于部署生成器部署的混合应用程序包。 混合应用程序包可以部署到云服务器上的部署服务。

    CLOUD APPLICATION WITH SECURE LOCAL ACCESS
    8.
    发明申请
    CLOUD APPLICATION WITH SECURE LOCAL ACCESS 有权
    具有安全本地访问权限的云应用程序

    公开(公告)号：US20160156700A1

    公开(公告)日：2016-06-02

    申请号：US14555687

    申请日：2014-11-28

    申请人： Zhigao CHEN ,  Qiushi WANG ,  Lin CAO

    发明人： Zhigao CHEN ,  Qiushi WANG ,  Lin CAO

    IPC分类号： H04L29/08 ,  H04L29/06

    CPC分类号： H04L67/10 ,  H04L63/08 ,  H04L63/10 ,  H04L63/107 ,  H04W4/60

    摘要： A framework for cloud applications with fast secured local access is described herein. In accordance with one aspect, a cloud application (App) on an application server on a cloud is provided. The cloud application includes a dispatcher having location information of a local resource on a local server required by the App. The dispatcher may be loaded onto an end-user device in response to a user accessing the cloud application from a browser on the end-user device on a local network. A request for the local resource may be issued to the local server by the dispatcher on the end-user device. A result of the request may be received from the local server by the dispatcher on the end-user device, and displayed on the browser.

    摘要翻译： 本文描述了具有快速安全本地访问的云应用的框架。 根据一个方面，提供云上的应用服务器上的云应用（App）。 云应用程序包括一个调度器，该调度程序具有应用程序所需的本地服务器上的本地资源的位置信息。 响应于用户从本地网络上的终端用户设备上的浏览器访问云应用，调度员可以被加载到终端用户设备上。 可以由终端用户设备上的调度员向本地服务器发出对本地资源的请求。 请求的结果可以由终端用户设备上的调度员从本地服务器接收，并且在浏览器上显示。

    TUMOR-TARGETED TNF-RELATED APOPTOSIS-INDUCING LIGAND'S VARIANT AND THE APPLICATION THEREOF
    9.
    发明申请
    TUMOR-TARGETED TNF-RELATED APOPTOSIS-INDUCING LIGAND'S VARIANT AND THE APPLICATION THEREOF 审中-公开
    肿瘤靶向性TNF相关性炎症诱导配体的变异及其应用

    公开(公告)号：US20130150566A1

    公开(公告)日：2013-06-13

    申请号：US13503771

    申请日：2011-07-06

    申请人： Zichun Hua ,  Lin Cao ,  Bo Tang

    发明人： Zichun Hua ,  Lin Cao ,  Bo Tang

    IPC分类号： C07K19/00

    CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/70575 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/74 ,  C12N9/485 ,  C12Y304/11002

    摘要： The invention belongs to the field of genetic engineering and biotechnology, and specifically discloses a design, preparation and pharmic application of a tumor-targeted TNF-related apoptosis-inducing ligand's variant. The tumor-targeted TNF-related apoptosis-inducing ligand's variant is generated by a fused protein which is consisted of the ligand of CD13, the connecting peptide and TNF-related apoptosis-inducing ligand's variant, and which is by the construction of coding gene of the variant according to the technology of genetic engineering and clone, soluble recombinant expression and ordinary separation and purification. The variant, produced by the method of preparation of the tumor-targeted TNF-related apoptosis-inducing ligand's variant, has favorable tumor-targeting characteristics and the significant enhancement of the anti-tumor effect. It is possible to reducing the required dosage of protein to the treatment effect, increasing the bioavailability, reducing the cost of treatment and overcome the potential toxic effects of the TNF-realated apoptosis-inducing ligand. Moreover, the preparation method of the tumor targeted TNF-related apoptosis-inducing ligand's variant of the present invention provides a method for producing the variant of soluble expression and high concern of polymer forms and a process of separation and purification thereof.

    摘要翻译： 本发明属于遗传工程和生物技术领域，具体公开了肿瘤靶向TNF相关凋亡诱导配体变体的设计，制备和药物应用。 肿瘤靶向的TNF相关凋亡诱导配体的变体由融合蛋白产生，其由CD13的配体，连接肽和TNF相关的细胞凋亡诱导配体的变体组成，并且通过构建编码基因 根据遗传工程和克隆技术的变异，可溶性重组表达和普通分离纯化。 通过制备肿瘤靶向TNF相关凋亡诱导配体变体的方法产生的变体具有有利的肿瘤靶向特征和抗肿瘤效果的显着增强。 可以将所需的蛋白质用量减少到治疗效果，提高生物利用度，降低治疗成本，克服TNF-诱导的细胞凋亡诱导配体的潜在毒性作用。 此外，本发明的肿瘤靶向TNF相关凋亡诱导配体变体的制备方法提供了生产可溶性表达变体和聚合物形式高度关注的方法及其分离和纯化方法。

    Cloud application with secure local access
    10.
    发明授权
    Cloud application with secure local access 有权

    公开(公告)号：US09794329B2

    公开(公告)日：2017-10-17

    申请号：US14555687

    申请日：2014-11-28

    申请人： Zhigao Chen ,  Qiushi Wang ,  Lin Cao

    发明人： Zhigao Chen ,  Qiushi Wang ,  Lin Cao

    IPC分类号： H04L29/08 ,  H04L29/06 ,  H04W4/00

    CPC分类号： H04L67/10 ,  H04L63/08 ,  H04L63/10 ,  H04L63/107 ,  H04W4/60

    摘要： A framework for cloud applications with fast secured local access is described herein. In accordance with one aspect, a cloud application (App) on an application server on a cloud is provided. The cloud application includes a dispatcher having location information of a local resource on a local server required by the App. The dispatcher may be loaded onto an end-user device in response to a user accessing the cloud application from a browser on the end-user device on a local network. A request for the local resource may be issued to the local server by the dispatcher on the end-user device. A result of the request may be received from the local server by the dispatcher on the end-user device, and displayed on the browser.