MELATONIN-BASED NASAL COMPOSITIONS AND USES THEREOF

    公开(公告)号:US20170326105A1

    公开(公告)日:2017-11-16

    申请号:US15592005

    申请日:2017-05-10

    Inventor: Ramon Coronado

    Abstract: Disclosed is an improved composition characterized in containing a combination of melatonin and 5-HTP in a nasal administration for the rapid treatment of insomnia, anxiety, and related disorders in mammals, including humans. The present invention relates also to a pharmaceutical composition comprising 5-HTP and melatonin which utilizes the known effects of two substances to provide sleep improvement, relaxation, and reduced anxiety via rapid delivery of the combination, via nasal administration, for short-term alleviation of sleep disorder and anxiety-related symptoms. The combined effects of 5-HTP and melatonin in the present invention provide a short-term increase in blood plasma levels of melatonin while simultaneously increasing the production of serotonin for purposes of achieving natural melatonin biosynthesis in combination with the increased melatonin content in blood plasma.

    All purpose portable ice chest
    3.
    发明授权
    All purpose portable ice chest 失效
    通用便携式冰箱

    公开(公告)号:US06574983B2

    公开(公告)日:2003-06-10

    申请号:US09955024

    申请日:2001-09-19

    Abstract: A portable ice chest used for maintaining its contents in a cooled or frozen state for an extended period of time. The ice chest includes an insulated cover with an inner compartment and an insulated container with a bottom compartment. The cover is adapted to fit airtight upon the top opening of the container. To maintain the contents of the ice chest in a frozen state, a refrigerant coolant such as dry ice is placed in the inner compartment only. To maintain the contents of the ice chest in a refrigerated state, a refrigerant coolant such as dry ice is placed in the bottom compartment only. Additionally, when no dry ice is placed in either compartments, the present invention can be used as a regular ice chest.

    Abstract translation: 用于将其内容物长时间冷却或冷冻的便携式冰箱。 冰箱包括具有内隔室的绝缘盖和具有底部隔室的绝热容器。 该盖适于气密地装在容器的顶部开口上。 为了将冰箱的内容物保持在冷冻状态,例如干冰等制冷剂冷却剂被放置在内部隔间内。 为了将冰箱的内容物保持在冷藏状态,仅在底部隔间内设置诸如干冰的制冷剂冷却剂。 此外,当没有干冰放置在两个隔室中时,本发明可以用作普通的冰箱。

    All purpose portable ice chest
    9.
    发明授权

    公开(公告)号:US07013670B2

    公开(公告)日:2006-03-21

    申请号:US10352009

    申请日:2003-01-27

    Abstract: A portable ice chest used for maintaining its contents in a cooled or frozen state for an extended period of time. The ice chest includes an insulated cover with an inner compartment and an insulated container with a bottom compartment. The cover is adapted to fit airtight upon the top opening of the container. To maintain the contents of the ice chest in a frozen state, a refrigerant coolant such as dry ice is placed in the inner compartment only. To maintain the contents of the ice chest in a refrigerated state, a refrigerant coolant such as dry ice is placed in the bottom compartment only. Additionally, when no dry ice is placed in either compartments, the present invention can be used as a regular ice chest.

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