知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.011 秒)

    Process for the production of 4,5-dichloro-6-ethylpyrimidine
    3.
    发明授权
    Process for the production of 4,5-dichloro-6-ethylpyrimidine 失效
    制备4,5-二氯-6-乙基嘧啶的方法

    公开(公告)号：US4977264A

    公开(公告)日：1990-12-11

    申请号：US433134

    申请日：1989-11-08

    申请人： Lester Mills ,  Felix Previdoli

    发明人： Lester Mills ,  Felix Previdoli

    IPC分类号： C07D239/30 ,  C07D239/36

    CPC分类号： C07D239/30

    摘要： 2-chloro-3-oxopentanoic acid alkyl ester is condensed with the addition of bases with formamidinium salts into 5-chloro-6-ethyl-4-hydroxypyrimidine. The latter is converted with phosphoryl chloride into 4,5-dichloro-6-ethylpyrimidine.

    摘要翻译： 2-氯-3-氧代戊酸烷基酯与将甲脒盐加入5-氯-6-乙基-4-羟基嘧啶中缩合。 后者用磷酰氯转化成4,5-二氯-6-乙基嘧啶。

    2-aza-4-(alkoxycarbonyl)spiro[4,5]decan-3-one
    4.
    发明授权
    2-aza-4-(alkoxycarbonyl)spiro[4,5]decan-3-one 失效
    2-烷基-4-（烷氧基羰基）螺[4,5]癸-3-酮

    公开(公告)号：US4956473A

    公开(公告)日：1990-09-11

    申请号：US400820

    申请日：1989-08-30

    申请人： Hans P. Mettler ,  Gareth Griffiths ,  Lester Mills ,  Felix Previdoli

    发明人： Hans P. Mettler ,  Gareth Griffiths ,  Lester Mills ,  Felix Previdoli

    IPC分类号： C07C229/28 ,  C07C255/46 ,  C07D209/54

    CPC分类号： C07C255/46 ,  C07C229/28 ,  C07D209/54 ,  C07C2101/14

    摘要： 2-Aza-4-(alkoxycarbonyl)spiro[4,5]-decan-3-one and a process for the production of it, starting either from cyclohexylidene malonic acid esters or cyclohexylidene cyanoalkylates. The cyclohexylidene malonic acid ester is reacted with hydrocyanic acid in the presence of a catalytic amount of alkali cyanide or with a stoichiometric amount of alkali cyanide, in an alcohol, and subsequently treated with an acid. The resultant (1-cyanocyclohexyl) malonic acid dialkyl ester is converted by catalytic hydrogenation into the product. The cyclohexylidene cyanoalkylate is reacted with a stoichiometric amount of alkali cyanide, in an alcohol or with hydrocyanic acid in the presence of a catalytic amount of an alkali cyanide. The resultant (1-cyanocyclohexyl)-cyanoacetic acid alkyl ester is reacted in an alcohol in an acid to provide (1-cyanocyclohexyl) malonic acid dialkyl ester. The later ester is converted by catalytic hydrogenation into the product. Process of using the product for the production of 1-(aminomethyl)cyclohexane acetic acid by converting the product with HCl or sulfuric acid at an elevated temperature.

    摘要翻译： 2-氮杂-4-（烷氧基羰基）螺[4,5] - 癸烷-3-酮及其制备方法，由亚环己基丙二酸酯或环己基氰基烷基酯开始。 在催化量的碱金属氰化物或化学计量的碱金属氰化物存在下，在醇中，将亚环己基丙二酸酯与氢氰酸反应，随后用酸处理。 所得（1-氰基环己基）丙二酸二烷基酯通过催化氢化转化成产物。 环己基氰基烷基化物与化学计量的碱金属氰化物，在醇中或与氢氰酸在催化量的碱金属氰化物的存在下反应。 所得（1-氰基环己基） - 氰基乙酸烷基酯在醇中在酸中反应，得到（1-氰基环己基）丙二酸二烷基酯。 后期的酯通过催化氢化转化成产物。 通过在高温下用HCl或硫酸转化产物来使用该产物生产1-（氨基甲基）环己烷乙酸的方法。