公开(公告)号：US12193995B2

公开(公告)日：2025-01-14

申请号：US16864418

申请日：2020-05-01

Applicant: LENTIGEN TECHNOLOGY, INC.

Inventor： Boro Dropulic ,  Rimas J. Orentas ,  Dina Schneider ,  Winfried Krueger

IPC: A61K39/00 ,  A61K38/17 ,  A61K39/235 ,  C07K14/725 ,  C12N5/0783

Abstract: Novel adoptive immunotherapy compositions comprising co-cultured lentiviral vector-transduced autologous antigen presentation cells and T cells are provided herein as well as are methods of use of same in a patient-specific combination immunotherapy that can be used to treat cancers and other diseases and conditions.

公开(公告)号：US20240108706A1

公开(公告)日：2024-04-04

申请号：US18528012

申请日：2023-12-04

Applicant: LENTIGEN TECHNOLOGY, INC. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K39/001113 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2803 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33

Abstract: Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making CAR T cells are also disclosed.

公开(公告)号：US11708408B2

公开(公告)日：2023-07-25

申请号：US16707505

申请日：2019-12-09

Applicant: LENTIGEN TECHNOLOGY, INC. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Dina Schneider ,  Rimas J. Orentas ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: C07K16/28 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  A61K35/17 ,  C12N5/0783 ,  A61K39/00 ,  A61K35/12

CPC classification number: C07K16/2803 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/001112 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70596 ,  C12N5/0636 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/035 ,  C07K2319/30 ,  C07K2319/33 ,  C12N2501/599 ,  C12N2510/00

Abstract: Chimeric antigen receptors containing human CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20210361709A1

公开(公告)日：2021-11-25

申请号：US17337018

申请日：2021-06-02

Applicant: LENTIGEN TECHNOLOGY, INC.

Inventor： Dina Schneider ,  Zhongyu Zhu ,  Boro Dropulic ,  Bang Khoa Vu ,  Leah Marie Alabanza

IPC: A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28

Abstract: Chimeric antigen receptors containing BCMA antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US11103533B2

公开(公告)日：2021-08-31

申请号：US16698186

申请日：2019-11-27

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Dina Schneider ,  Rimas J. Orentas ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/02 ,  C07K16/28 ,  C12N15/86

Abstract: Chimeric antigen receptors containing CD38 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US11045497B2

公开(公告)日：2021-06-29

申请号：US16698186

申请日：2019-11-27

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Dina Schneider ,  Rimas J. Orentas ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/02 ,  C07K16/28 ,  C12N15/86

Abstract: Chimeric antigen receptors containing CD38 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20200231648A1

公开(公告)日：2020-07-23

申请号：US16692957

申请日：2019-11-22

Applicant: Lentigen Technology, Inc.

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Waleed M. Haso ,  Stefan Miltenyi ,  Boro Dropulic

IPC: C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61P35/02 ,  A61K39/00 ,  A61K35/17 ,  C12N15/85

Abstract: Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.

公开(公告)号：US10550179B2

公开(公告)日：2020-02-04

申请号：US16252158

申请日：2019-01-18

Applicant: Lentigen Technology Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: C12N15/62 ,  C12N15/63 ,  C12N15/09 ,  C12N15/10 ,  C12N5/0783 ,  C07K16/28 ,  C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  A61K35/17 ,  A61K39/395 ,  C07K16/18 ,  A61P35/02 ,  A61P35/00

Abstract: Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US10426797B2

公开(公告)日：2019-10-01

申请号：US15934770

申请日：2018-03-23

Applicant: Lentigen Technology, Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: A61K39/00 ,  C12Q1/6876 ,  C12N15/86 ,  A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61P35/02 ,  A61K39/395 ,  A61K48/00

Abstract: Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20180355052A1

公开(公告)日：2018-12-13

申请号：US16050754

申请日：2018-07-31

Applicant: Lentigen Technology, Inc.

Inventor： Rimas J. Orentas ,  Boro Dropulic ,  Dina Schneider

IPC: C07K16/28 ,  C07K14/705 ,  A61P35/02 ,  A61K35/17 ,  C07K14/725

CPC classification number: C07K16/2887 ,  A61K35/17 ,  A61P35/02 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K16/2803 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

Abstract: Chimeric antigen receptors containing CD19/CD20 or CD20/CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.