公开(公告)号：US20240307448A1

公开(公告)日：2024-09-19

申请号：US18624207

申请日：2024-04-02

Applicant: Lentigen Technology, Inc.

Inventor： Dina Schneider ,  Boro Dropulic ,  Brian Robert Webster

IPC: A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K35/17 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/03

Abstract: Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.

公开(公告)号：US11453719B2

公开(公告)日：2022-09-27

申请号：US16588591

申请日：2019-09-30

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: C07K16/28 ,  C07K14/725 ,  A61K35/17 ,  C12N15/62 ,  C12N15/113 ,  A61P35/00 ,  A61K38/17 ,  C07K14/15 ,  C07K14/705 ,  C07K14/735 ,  C07K14/73

Abstract: Chimeric antigen receptors containing ROR1 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20220169698A1

公开(公告)日：2022-06-02

申请号：US17540377

申请日：2021-12-02

Applicant: Lentigen Technology, Inc.

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Waleed M. Haso ,  Stefan Miltenyi ,  Boro Dropulic

IPC: C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61P35/02 ,  A61K39/00 ,  A61K35/17 ,  C12N15/85

Abstract: Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.

公开(公告)号：US11208455B2

公开(公告)日：2021-12-28

申请号：US16692957

申请日：2019-11-22

Applicant: Lentigen Technology, Inc.

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Waleed M. Haso ,  Stefan Miltenyi ,  Boro Dropulic

IPC: C12N15/63 ,  C12N15/13 ,  C07K14/47 ,  A61K39/395 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61P35/02 ,  A61K39/00 ,  A61K35/17 ,  C12N15/85

Abstract: Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.

公开(公告)号：US20210379110A1

公开(公告)日：2021-12-09

申请号：US17354624

申请日：2021-06-22

Applicant: Lentigen Technology, Inc. ,  University of Colorado

Inventor： Dina Schneider ,  Boro Dropulic ,  Terry James Fry

IPC: A61K35/17 ,  C07K16/28 ,  C07K14/705 ,  C07K14/725

Abstract: Chimeric antigen receptors containing TSLPR-CD19 and TSLPR-CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20210353675A1

公开(公告)日：2021-11-18

申请号：US17331733

申请日：2021-05-27

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Dina Schneider ,  Rimas J. Orentas ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: A61K35/17 ,  A61P35/02 ,  C12N15/86 ,  C07K16/28

Abstract: Chimeric antigen receptors containing CD38 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20210206839A1

公开(公告)日：2021-07-08

申请号：US17122847

申请日：2020-12-15

Applicant: LENTIGEN TECHNOLOGY, INC.

Inventor： Kim Anthony Gonda ,  Dina Schneider ,  Rimas Orentas ,  Boro Dropulic

IPC: C07K16/10 ,  C07K14/705 ,  A61P35/00 ,  A61P31/18 ,  A61K35/17 ,  C07K14/725

Abstract: Chimeric antigen receptors (CARs) containing HIV envelope antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing HIV-infection in a subject, and methods of making CAR T cells are also disclosed. Results of treating or preventing HIV-infection, and results of making CAR T cells are also disclosed.

公开(公告)号：US20210130479A1

公开(公告)日：2021-05-06

申请号：US17095982

申请日：2020-11-12

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C12N15/10 ,  C12N15/86

Abstract: Chimeric antigen receptors containing CD123 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US20200010555A1

公开(公告)日：2020-01-09

申请号：US16578063

申请日：2019-09-20

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: C07K16/28 ,  C07K14/705 ,  C12N15/10 ,  C12N15/86 ,  C07K14/725 ,  A61K35/17

Abstract: Chimeric antigen receptors containing CD123 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US10428141B2

公开(公告)日：2019-10-01

申请号：US16179364

申请日：2018-11-02

Applicant: Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC: A61K35/17 ,  C12N1/20 ,  C12N5/00 ,  C07K14/00 ,  A61K48/00 ,  C07K16/28 ,  C12N15/62 ,  C12N15/113 ,  A61P35/00 ,  A61K38/17 ,  C07K14/15 ,  C07K14/705 ,  C07K14/735 ,  C07K14/73 ,  C07K14/725

Abstract: Chimeric antigen receptors containing ROR1 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.