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公开(公告)号：US5622867A
公开(公告)日：1997-04-22
申请号：US326036
申请日：1994-10-19
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/19 , Y10T436/108331 , Y10T436/2525
摘要： This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.
摘要翻译： 本发明提供了一种在降低的温度下延长人血小板保存的方法。 该方法使用抑制剂系统，其使血小板维持其盘状并在储存期间保持其功能完整性。 这是通过在储存期间中断正常的血小板功能来实现的，以便有助于保持血小板活化和失去其形状。 在使用血小板输血之前，通过将抑制剂系统从血小板上清洗而使其恢复到正常的功能水平。
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公开(公告)号：US06221669B1
公开(公告)日：2001-04-24
申请号：US08600343
申请日：1996-02-13
IPC分类号： G01N3100
CPC分类号： A01N1/0226 , A01N1/02 , A61K35/19 , Y02A50/471 , Y10T436/108331
摘要： This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to retain their functional integrity during storage. In addition, the inhibitor system prevents the generation of cytokines in the platelet preparation during storage at both 22° C. and 4° C. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.
摘要翻译： 本发明提供了一种在降低的温度下延长人血小板保存的方法。 该方法使用抑制剂系统，使血小板在储存期间保持其功能完整性。 此外，抑制剂系统在22℃和4℃下储存期间可防止血小板制剂中的细胞因子的产生。这是通过在储存期间中断正常的血小板功能来实现的，以帮助血小板激活并失去它们 形状。 在使用血小板输血之前，通过将抑制剂系统从血小板上清洗而使其恢复到正常的功能水平。
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3.发明授权Composition comprising three platelet lesion inhibitors for platelet storage 失效组合物，其包含用于血小板储存的三种血小板损伤抑制剂
公开(公告)号：US5919614A
公开(公告)日：1999-07-06
申请号：US852921
申请日：1997-05-08
CPC分类号： A61K35/19 , A01N1/02 , A01N1/0226
摘要： This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets. In particular, compositions comprising amiloride, adenosine and sodium nitroprusside are disclosed.
摘要翻译： 本发明提供了一种在降低的温度下延长人血小板保存的方法。 该方法使用抑制剂系统，其使血小板维持其盘状并在储存期间保持其功能完整性。 这是通过在储存期间中断正常的血小板功能来实现的，以便有助于保持血小板活化和失去其形状。 在使用血小板输血之前，通过将抑制剂系统从血小板上清洗而使其恢复到正常的功能水平。 特别地，公开了包含阿米洛利，腺苷和硝普钠的组合物。
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