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    Pro-angiogenic peptides and uses thereof
    2.
    发明授权
    Pro-angiogenic peptides and uses thereof 有权
    前血管生成肽及其用途

    公开(公告)号：US08460697B2

    公开(公告)日：2013-06-11

    申请号：US12823556

    申请日：2010-06-25

    申请人： Laura L. Eggink ,  J. Kenneth Hoober

    发明人： Laura L. Eggink ,  J. Kenneth Hoober

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K14/001 ,  C07K7/06

    摘要： This present invention is directed to peptides, compositions, and methods for modulating endogenous cytokine expression in a subject. More specifically, the invention provides peptides useful in regulating the release of a specific pattern of cytokines that promote angiogenesis and/or can be used to modulate the immune system of a subject.

    摘要翻译： 本发明涉及用于调节受试者内源性细胞因子表达的肽，组合物和方法。 更具体地，本发明提供了可用于调节促进血管生成和/或可用于调节受试者的免疫系统的细胞因子的特定模式的释放的肽。

    PRO-ANGIOGENIC PEPTIDES AND USES THEREOF
    4.
    发明申请
    PRO-ANGIOGENIC PEPTIDES AND USES THEREOF 有权
    原发性肽及其用途

    公开(公告)号：US20100286040A1

    公开(公告)日：2010-11-11

    申请号：US12823556

    申请日：2010-06-25

    申请人： Laura L. Eggink ,  J. Kenneth Hoober

    发明人： Laura L. Eggink ,  J. Kenneth Hoober

    IPC分类号： A61K38/08 ,  C07K7/06 ,  A61P17/00

    CPC分类号： C07K14/001 ,  C07K7/06

    摘要： This present invention is directed to peptides, compositions, and methods for modulating endogenous cytokine expression in a subject. More specifically, the invention provides peptides useful in regulating the release of a specific pattern of cytokines that promote angiogenesis and/or can be used to modulate the immune system of a subject.

    摘要翻译： 本发明涉及用于调节受试者内源性细胞因子表达的肽，组合物和方法。 更具体地，本发明提供了可用于调节促进血管生成和/或可用于调节受试者的免疫系统的细胞因子的特定模式的释放的肽。

    Therapeutic and diagnostic peptides
    5.
    发明授权
    Therapeutic and diagnostic peptides 有权
    治疗和诊断肽

    公开(公告)号：US07811995B2

    公开(公告)日：2010-10-12

    申请号：US11955226

    申请日：2007-12-12

    申请人： Laura L. Eggink ,  Kenneth J. Hoober

    发明人： Laura L. Eggink ,  Kenneth J. Hoober

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/001

    摘要： This invention generally relates to peptides useful for medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines and, in combination with antibodies against human pathogens such as the immunodeficiency virus (HIV), inhibit replication of such pathogens. The peptides interact synergistically with pathogen-directed antibodies without producing or sustaining serious side-effects such as inflammation, and provide the potential for treatment modalities that are non-specific with respect to pathogen and cell type. Therefore, the peptides of the present invention have wide applicability with respect to medical treatment of pathogen-mediated infections, and the potential to enhance well-being.

    摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽，并且与针对人类病原体（例如免疫缺陷病毒（HIV））的抗体结合抑制这种病原体的复制。 肽与病原体定向的抗体协同作用而不产生或维持诸如炎症的严重副作用，并且提供了关于病原体和细胞类型非特异性的治疗方式的潜力。 因此，本发明的肽在病原体介导的感染的医疗上具有广泛的适用性，并且具有增强健康的潜力。

    Therapeutic peptides and uses thereof
    7.
    发明授权
    Therapeutic peptides and uses thereof 有权
    治疗肽及其用途

    公开(公告)号：US08496942B2

    公开(公告)日：2013-07-30

    申请号：US12823560

    申请日：2010-06-25

    申请人： Laura L. Eggink ,  J. Kenneth Hoober

    发明人： Laura L. Eggink ,  J. Kenneth Hoober

    IPC分类号： A61K38/08 ,  A61K39/39 ,  C07K7/06

    CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K5/1008 ,  C07K5/1013 ,  C07K7/06

    摘要： The present invention is directed to a family of therapeutic peptides capable of modulating cytokine expression and/or stimulating the immune system of subject without producing or sustaining serious side-effects. Methods using the peptides to modulate cytokine expression in a subject, treat a disease, enhance vaccination, and stimulate a subject's immune system response are also disclosed.

    摘要翻译： 本发明涉及能够调节细胞因子表达和/或刺激受试者的免疫系统的一系列治疗性肽，而不产生或维持严重的副作用。 还公开了使用肽来调节受试者中的细胞因子表达，治疗疾病，增强免疫接种和刺激受试者的免疫系统应答的方法。

    Pro-angiogenic peptides
    8.
    发明授权
    Pro-angiogenic peptides 有权
    促血管生成肽

    公开(公告)号：US07838497B2

    公开(公告)日：2010-11-23

    申请号：US11955143

    申请日：2007-12-12

    申请人： Laura L. Eggink ,  J. Kenneth Hoober

    发明人： Laura L. Eggink ,  J. Kenneth Hoober

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00

    摘要： This present invention generally relates to peptides, compositions, treatment methods, and devices useful for the medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines. The peptides of the invention can regulate the release of a specific pattern of cytokines that promote angiogenesis, and modulate the immune system of a subject, without inducing deleterious side effects such as inflammation. Therefore, the peptides have therapeutic importance, particularly with respect to wound healing and restoration of circulation to damaged tissues.

    摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽，组合物，治疗方法和装置。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽。 本发明的肽可以调节促进血管生成的细胞因子的特定模式的释放，并且调节受试者的免疫系统，而不会引起有害的副作用如炎症。 因此，肽具有治疗重要性，特别是在伤口愈合和对受损组织的循环恢复方面。

    THERAPEUTIC AND DIAGNOSTIC PEPTIDES
    10.
    发明申请
    THERAPEUTIC AND DIAGNOSTIC PEPTIDES 有权
    治疗和诊断肽

    公开(公告)号：US20080292650A1

    公开(公告)日：2008-11-27

    申请号：US11955226

    申请日：2007-12-12

    申请人： Laura L. Eggink ,  J. Kenneth Hoober

    发明人： Laura L. Eggink ,  J. Kenneth Hoober

    IPC分类号： A61K39/00 ,  A61K38/00 ,  G01N33/00 ,  C12Q1/70 ,  A61P31/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/001

    摘要： This invention generally relates to peptides useful for medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines and, in combination with antibodies against human pathogens such as the immunodeficiency virus (HIV), inhibit replication of such pathogens. The peptides interact synergistically with pathogen-directed antibodies without producing or sustaining serious side-effects such as inflammation, and provide the potential for treatment modalities that are non-specific with respect to pathogen and cell type. Therefore, the peptides of the present invention have wide applicability with respect to medical treatment of pathogen-mediated infections, and the potential to enhance well-being.

    摘要翻译： 本发明一般涉及可用于医学诊断和治疗病原性疾病的肽。 更具体地，本发明涉及可以刺激产生治疗有益的细胞因子的免疫刺激肽，并且与针对人类病原体（例如免疫缺陷病毒（HIV））的抗体结合抑制这种病原体的复制。 肽与病原体定向的抗体协同作用而不产生或维持诸如炎症的严重副作用，并且提供了关于病原体和细胞类型非特异性的治疗方式的潜力。 因此，本发明的肽在病原体介导的感染的医疗上具有广泛的适用性，并且具有增强健康的潜力。