公开(公告)号：US20100010205A1

公开(公告)日：2010-01-14

申请号：US12375094

申请日：2007-07-30

申请人： Kyu Wann Kim ,  Kyoung Soo Kim ,  Young Won Park ,  Young Jun Park ,  Won Kyoung Lee

发明人： Kyu Wann Kim ,  Kyoung Soo Kim ,  Young Won Park ,  Young Jun Park ,  Won Kyoung Lee

IPC分类号： C07H3/02

CPC分类号： C07H19/073 ,  Y02P20/55

摘要： Disclosed herein are novel naphthalene-2-carboxylate derivatives of Formula (I), which are useful for the synthesis of gemcitabine, as well as a preparation method. The novel derivatives have naphthalene-2-carboxlate as the hydroxy protecting group of 2-deoxy-2,2-difluoro-pentofuranose-1-ulose. (I) wherein R1 and R2 are each independently hydrogen, methyl, chloro, fluoro, bromo, iodo, methoxy, ethoxy or nitro.

摘要翻译： 本文公开了式（I）的新颖的萘-2-羧酸酯衍生物，其可用于吉西他滨的合成以及制备方法。 该新型衍生物具有萘-2-甲酸酯作为2-脱氧-2,2-二氟 - 戊呋糖-1-尿苷的羟基保护基。 （I）其中R 1和R 2各自独立地为氢，甲基，氯，氟，溴，碘，甲氧基，乙氧基或硝基。