发明申请
US20100010205A1 NAPHTHALENE 2-CARBOXYLATE DERIVATIVE USEFUL FOR SYNTHESIZING GEMCITABINE AND A METHOD FOR PREPARING THE SAME
审中-公开
用于合成格列宾的萘甲酸2-羧酸酯衍生物及其制备方法
- 专利标题： NAPHTHALENE 2-CARBOXYLATE DERIVATIVE USEFUL FOR SYNTHESIZING GEMCITABINE AND A METHOD FOR PREPARING THE SAME
- 专利标题（中）： 用于合成格列宾的萘甲酸2-羧酸酯衍生物及其制备方法
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申请号： US12375094申请日： 2007-07-30
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公开(公告)号： US20100010205A1公开(公告)日： 2010-01-14
- 发明人: Kyu Wann Kim , Kyoung Soo Kim , Young Won Park , Young Jun Park , Won Kyoung Lee
- 申请人： Kyu Wann Kim , Kyoung Soo Kim , Young Won Park , Young Jun Park , Won Kyoung Lee
- 申请人地址： KR Chungcheongbuk-do KR Whasung City, Kyunggi-do
- 专利权人： YUIL PHARM TECH CO., LTD,CHIRO GENIX CO., LTD
- 当前专利权人： YUIL PHARM TECH CO., LTD,CHIRO GENIX CO., LTD
- 当前专利权人地址： KR Chungcheongbuk-do KR Whasung City, Kyunggi-do
- 优先权： KR10-2006-0072786 20060801
- 国际申请： PCT/KR07/03648 WO 20070730
- 主分类号： C07H3/02
- IPC分类号： C07H3/02
摘要：
Disclosed herein are novel naphthalene-2-carboxylate derivatives of Formula (I), which are useful for the synthesis of gemcitabine, as well as a preparation method. The novel derivatives have naphthalene-2-carboxlate as the hydroxy protecting group of 2-deoxy-2,2-difluoro-pentofuranose-1-ulose. (I) wherein R1 and R2 are each independently hydrogen, methyl, chloro, fluoro, bromo, iodo, methoxy, ethoxy or nitro.
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