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公开(公告)号：US08309355B2
公开(公告)日：2012-11-13
申请号：US12384935
申请日：2009-04-10
Applicant: Krys Bankiewicz , Janet Cunningham
Inventor： Krys Bankiewicz , Janet Cunningham
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the central nervous system (CNS) are provided for the treatment of CNS disorders, particularly those disorders which involve the neurotransmitter dopamine. The methods entail providing rAAV virions that comprise a transgene encoding aromatic amino acid decarboxylase (AADC) and administering the virions to the brain of a mammal using a non-manual pump.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至中枢神经系统（CNS）的方法用于治疗CNS疾病，特别是涉及神经递质多巴胺的那些疾病。 所述方法需要提供包含编码芳族氨基酸脱羧酶（AADC）的转基因的rAAV病毒粒子，并使用非手动泵将病毒粒子施用于哺乳动物的脑部。
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2.发明授权公开(公告)号：US06953575B2
公开(公告)日：2005-10-11
申请号：US09887854
申请日：2001-06-21
Applicant: Krys Bankiewicz , Janet Cunningham , Jamie L. Eberling
Inventor： Krys Bankiewicz , Janet Cunningham , Jamie L. Eberling
IPC: C12N15/09 , A61K31/198 , A61K35/76 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/51 , A61K47/48 , A61K48/00 , A61K51/00 , A61K51/04 , A61P25/16 , A01N63/00 , A01N43/04 , C12N15/00 , C12N15/63
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。 还提供治疗帕金森病的方法。
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公开(公告)号：US20050180955A1
公开(公告)日：2005-08-18
申请号：US11102521
申请日：2005-04-08
Applicant: Krys Bankiewicz , Janet Cunningham , Jamie Eberling
Inventor： Krys Bankiewicz , Janet Cunningham , Jamie Eberling
IPC: C12N15/09 , A61K31/198 , A61K35/76 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/51 , A61K47/48 , A61K48/00 , A61K51/00 , A61K51/04 , A61P25/16 , A61K9/22 , C12N15/861
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。 还提供治疗帕金森病的方法。
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Patent Agency Ranking
公开(公告)号：US20130101510A1
公开(公告)日：2013-04-25
申请号：US13647155
申请日：2012-10-08
Applicant: Krys BANKIEWICZ , Janet Cunningham
Inventor： Krys BANKIEWICZ , Janet Cunningham
IPC: A61K31/198 , A61K45/06 , A61K35/76
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。 还提供治疗帕金森病的方法。
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公开(公告)号：US20100104537A1
公开(公告)日：2010-04-29
申请号：US12384935
申请日：2009-04-10
Applicant: Krys Bankiewicz , Janet Cunningham
Inventor： Krys Bankiewicz , Janet Cunningham
IPC: A61K35/76
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。 还提供治疗帕金森病的方法。
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公开(公告)号：US07182944B2
公开(公告)日：2007-02-27
申请号：US10132681
申请日：2002-04-25
Applicant: Krys Bankiewicz
Inventor： Krys Bankiewicz
CPC classification number: C12N15/86 , A61K48/00 , C12N2750/14143
Abstract: This invention provides a method of increasing the volume of distribution of a nucleic acid encoding a therapeutic agent in a tissue in a subject during localized delivery, comprising administering to the tissue in the subject a nucleic acid encoding a therapeutic agent and a facilitating agent, whereby the inclusion of the facilitating agent increases the volume of distribution of the nucleic acid encoding a therapeutic agent in the tissue.
Abstract translation: 本发明提供了一种在局部递送期间增加编码受试者组织中的治疗剂的核酸分布体积的方法，包括向受试者的组织施用编码治疗剂和促进剂的核酸，由此 促进剂的包含增加了组织中编码治疗剂的核酸的分布体积。
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公开(公告)号：US07534613B2
公开(公告)日：2009-05-19
申请号：US11102521
申请日：2005-04-08
Applicant: Krys Bankiewicz , Janet Cunningham
Inventor： Krys Bankiewicz , Janet Cunningham
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。 还提供治疗帕金森病的方法。
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8.发明授权Methods of treating Parkinson's disease using recombinant adeno-associated vector (rAAV) 有权使用重组腺相关载体（rAAV）治疗帕金森病的方法公开(公告)号：US06309634B1
公开(公告)日：2001-10-30
申请号：US09320171
申请日：1999-06-26
Applicant: Krys Bankiewicz , Janet Cunningham
Inventor： Krys Bankiewicz , Janet Cunningham
IPC: A01N4304
CPC classification number: A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Abstract translation: 提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。 还提供治疗帕金森病的方法。
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