公开(公告)号：US20240425566A1

公开(公告)日：2024-12-26

申请号：US18828110

申请日：2024-09-09

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Paula Maria Wilhelmina VAN HELDEN ,  Mark Jeroen KWAKKENBOS ,  Hergen SPITS ,  Tim BEAUMONT

IPC: C07K16/00 ,  C07K16/10 ,  C12N5/0781 ,  C12N15/86 ,  C12P21/00

Abstract: The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.

公开(公告)号：US20240360239A1

公开(公告)日：2024-10-31

申请号：US18644984

申请日：2024-04-24

Applicant: Kling Biotherapeutics B.V.

Inventor： Hergen SPITS ,  Paula Maria Wilhelmina VAN HELDEN ,  Remko SCHOTTE ,  Wouter POS ,  Christien FATMAWATI ,  Danïel Michiel GO ,  Koen WAGNER ,  Julien Christian VILLAUDY

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  G01N33/574

CPC classification number: C07K16/2896 ,  A61P35/00 ,  C07K14/70596 ,  C07K16/2818 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/70596

Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.

公开(公告)号：US20230235018A1

公开(公告)日：2023-07-27

申请号：US18050272

申请日：2022-10-27

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Hergen SPITS ,  Marijn Aletta GILLISSEN ,  Martijn KEDDE ,  Mette Deborah HAZENBERG ,  Paula Maria Wilhelmina VAN HELDEN ,  Wouter POS

IPC: C07K14/705 ,  C07K14/435 ,  C07K16/28 ,  G01N33/574

CPC classification number: C07K14/70596 ,  C07K14/435 ,  C07K16/2896 ,  G01N33/57426 ,  A61K38/00

Abstract: The present invention provides novel compounds comprising an antigen of AML cells, and uses thereof.

公开(公告)号：US11629200B2

公开(公告)日：2023-04-18

申请号：US16733376

申请日：2020-01-03

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Hergen Spits ,  Tim Beaumont ,  Marijn Aletta Gillissen ,  Adrianus Quirinus Bakker ,  Mette Deborah Hazenberg ,  Martijn Kedde

IPC: C07K16/30 ,  C07K16/06 ,  A61K47/68 ,  C07K16/40 ,  C12P21/00 ,  G01N33/574

Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.

公开(公告)号：US11524989B2

公开(公告)日：2022-12-13

申请号：US15737924

申请日：2016-06-24

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Hergen Spits ,  Marijn Aletta Gillissen ,  Martijn Kedde ,  Mette Deborah Hazenberg ,  Paula Maria Wilhelmina van Helden ,  Wouter Pos

IPC: C07K14/435 ,  C07K14/705 ,  C07K16/28 ,  G01N33/574 ,  A61K38/00

Abstract: The present invention provides novel compounds comprising an antigen of AML cells, and uses thereof.

公开(公告)号：US12084681B2

公开(公告)日：2024-09-10

申请号：US16575518

申请日：2019-09-19

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Paula Maria Wilhelmina Van Helden ,  Mark Jeroen Kwakkenbos ,  Hergen Spits ,  Tim Beaumont

IPC: C12N5/0781 ,  A61K38/00 ,  C07K16/00 ,  C07K16/10 ,  C12N15/06 ,  C12N15/86 ,  C12P21/00

CPC classification number: C12N5/0635 ,  C07K16/00 ,  C07K16/1018 ,  C12N15/86 ,  C12P21/005 ,  C07K2317/14 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2740/13045 ,  C12N2810/6054

Abstract: The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.

公开(公告)号：US20240317880A1

公开(公告)日：2024-09-26

申请号：US17789940

申请日：2021-01-08

Applicant: Kling Biotherapeutics B.V.

Inventor： Tim BEAUMONT ,  Sabrina Julia Louisa MERAT ,  Mark Jeroen KWAKKENBOS ,  Martijn KEDDE ,  Hergen SPITS

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  C07K16/22 ,  C12N5/0783

CPC classification number: C07K16/2896 ,  A61K47/6803 ,  C07K16/22 ,  C07K16/2809 ,  C12N5/0636 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present invention relates to epithelial cadherin-specific antibodies, as well as uses thereof in the diagnosis and treatment of diseases such as cancer.

公开(公告)号：US11999793B2

公开(公告)日：2024-06-04

申请号：US17476650

申请日：2021-09-16

Applicant: Kling Biotherapeutics B.V.

Inventor： Hergen Spits ,  Paula Maria Wilhelmina Van Helden ,  Remko Schotte ,  Wouter Pos ,  Christien Fatmawati ,  Danïel Michiel Go ,  Koen Wagner ,  Julien Christian Villaudy

IPC: C07K16/28 ,  A61P35/00 ,  C07K14/705 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61P35/00 ,  C07K14/70596 ,  C07K16/2818 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/70596

Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.

公开(公告)号：US20230242667A1

公开(公告)日：2023-08-03

申请号：US18172417

申请日：2023-02-22

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Hergen SPITS ,  Tim BEAUMONT ,  Marijn Aletta GILLISSEN ,  Adrianus Quirinus BAKKER ,  Mette Deborah HAZENBERG ,  Martijn KEDDE

IPC: C07K16/30 ,  C07K16/06 ,  A61K47/68 ,  C07K16/40 ,  C12P21/00 ,  G01N33/574

CPC classification number: C07K16/3061 ,  C07K16/06 ,  A61K47/6851 ,  C07K16/40 ,  C12P21/005 ,  G01N33/57492 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/705

Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.