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    Point of Care Heparin Determination System
    1.
    发明申请
    Point of Care Heparin Determination System 有权
    护肝点肝素测定系统

    公开(公告)号：US20100181210A1

    公开(公告)日：2010-07-22

    申请号：US12748918

    申请日：2010-03-29

    申请人： Wei Qin ,  Daniel S. Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Dean Nippoldt ,  Vitally G. Sitko ,  Qingsham (Sam) Ye ,  Narayanan Ramamurthy

    发明人： Wei Qin ,  Daniel S. Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Dean Nippoldt ,  Vitally G. Sitko ,  Qingsham (Sam) Ye ,  Narayanan Ramamurthy

    IPC分类号： G01N33/50 ,  G01N27/26

    CPC分类号： G01N27/3335 ,  A61M1/3675 ,  G01N27/333 ,  G01N33/86

    摘要： Methods and devices for point of care determination of heparin concentration in blood are described. Cartridges including protamine ion sensitive electrodes (ISEs) and reference electrodes and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.

    摘要翻译： 描述了血液中肝素浓度的护理点测定方法和装置。 提供了包括鱼精蛋白离子敏感电极（ISE）和用于自动确定药筒中肝素浓度的参比电极和系统的药盒。 一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。 可以通过测量电极电位变化率的初始斜率，并将斜率与已知的精蛋白浓度斜率值进行比较来确定过量鱼精蛋白浓度。 在一些药筒中，振荡压力源通过鱼精蛋白ISE来回移动血液 - 鱼精蛋白混合物。 一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。 鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。 聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。 一些硬链段可以包括亚甲基二苯基。 一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

    Point of care heparin determination system
    2.
    发明授权
    Point of care heparin determination system 有权
    护理点肝素测定系统

    公开(公告)号：US07699966B2

    公开(公告)日：2010-04-20

    申请号：US11126887

    申请日：2005-05-11

    申请人： Wei Qin ,  Daniel S. Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Dean Nippoldt ,  Vitally G. Sitko ,  Qingshan (Sam) Ye ,  Narayanan Ramamurthy

    发明人： Wei Qin ,  Daniel S. Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Dean Nippoldt ,  Vitally G. Sitko ,  Qingshan (Sam) Ye ,  Narayanan Ramamurthy

    IPC分类号： G01N27/333

    CPC分类号： G01N27/3335 ,  A61M1/3675 ,  G01N27/333 ,  G01N33/86

    摘要： Methods and devices for point of care determination of heparin concentration in blood are described. Cartridges including protamine ion sensitive electrodes (ISEs) and reference electrodes and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.

    摘要翻译： 描述了血液中肝素浓度的护理点测定方法和装置。 提供了包括鱼精蛋白离子敏感电极（ISE）和用于自动确定药筒中肝素浓度的参比电极和系统的药盒。 一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。 过量的鱼精蛋白浓度可以通过测量电极电位变化率的初始斜率来确定，并将斜率与已知的鱼精蛋白浓度斜率值进行比较。在一些药筒中，振荡压力源将血 - 鱼精蛋白混合物来回移动穿过鱼精蛋白 ISE。 一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。 鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。 聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。 一些硬链段可以包括亚甲基二苯基。 一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

    Point of care heparin determination system
    4.
    发明申请
    Point of care heparin determination system 有权
    护理点肝素测定系统

    公开(公告)号：US20060016701A1

    公开(公告)日：2006-01-26

    申请号：US11126887

    申请日：2005-05-11

    申请人： Wei Qin ,  Daniel Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Nippoldt ,  Vitally Sitko ,  Qingshan (Sam) Ye ,  Narayanan Ramamurthy

    发明人： Wei Qin ,  Daniel Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Nippoldt ,  Vitally Sitko ,  Qingshan (Sam) Ye ,  Narayanan Ramamurthy

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3335 ,  A61M1/3675 ,  G01N27/333 ,  G01N33/86

    摘要： Methods and devices for point of care determination of heparin concentration in blood are described. Cartridges including protamine ion sensitive electrodes (ISEs) and reference electrodes and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.

    摘要翻译： 描述了血液中肝素浓度的护理点测定方法和装置。 提供了包括鱼精蛋白离子敏感电极（ISE）和用于自动确定药筒中肝素浓度的参比电极和系统的药盒。 一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。 可以通过测量电极电位变化率的初始斜率，并将斜率与已知的精蛋白浓度斜率值进行比较来确定过量鱼精蛋白浓度。 在一些药筒中，振荡压力源通过鱼精蛋白ISE来回移动血液 - 鱼精蛋白混合物。 一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。 鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。 聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。 一些硬链段可以包括亚甲基二苯基。 一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

    Point of care heparin determination system
    5.
    发明授权
    Point of care heparin determination system 有权
    护理点肝素测定系统

    公开(公告)号：US08801918B2

    公开(公告)日：2014-08-12

    申请号：US12748918

    申请日：2010-03-29

    申请人： Wei Qin ,  Daniel S. Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Dean Nippoldt ,  Vitally G. Sitko ,  Qingshan (Sam) Ye ,  Narayanan Ramamurthy

    发明人： Wei Qin ,  Daniel S. Cheek ,  Christopher Hobot ,  Kelvin Bonnema ,  Randy Meyer ,  Douglas Dean Nippoldt ,  Vitally G. Sitko ,  Qingshan (Sam) Ye ,  Narayanan Ramamurthy

    IPC分类号： G01N27/333 ,  G01N33/86 ,  A61M1/36

    CPC分类号： G01N27/3335 ,  A61M1/3675 ,  G01N27/333 ,  G01N33/86

    摘要： Methods and devices for point of care determination of heparin concentration in blood are described. Cartridges including protamine ion sensitive electrodes (ISEs) and reference electrodes and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.

    摘要翻译： 描述了血液中肝素浓度的护理点测定方法和装置。 提供了包括鱼精蛋白离子敏感电极（ISE）和用于自动确定药筒中肝素浓度的参比电极和系统的药盒。 一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。 可以通过测量电极电位变化率的初始斜率，并将斜率与已知的精蛋白浓度斜率值进行比较来确定过量鱼精蛋白浓度。 在一些药筒中，振荡压力源通过鱼精蛋白ISE来回移动血液 - 鱼精蛋白混合物。 一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。 鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。 聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。 一些硬链段可以包括亚甲基二苯基。 一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

    Medical devices containing segmented polyurethane biomaterials
    6.
    发明授权
    Medical devices containing segmented polyurethane biomaterials 失效
    含有分段聚氨酯生物材料的医疗器械

    公开(公告)号：US06915168B1

    公开(公告)日：2005-07-05

    申请号：US09423332

    申请日：1998-05-08

    申请人： Michael D. Benz ,  Kelvin Bonnema ,  Edward Didomenico ,  Christopher M. Hobot ,  David L. Miller

    发明人： Michael D. Benz ,  Kelvin Bonnema ,  Edward Didomenico ,  Christopher M. Hobot ,  David L. Miller

    IPC分类号： A61L31/06 ,  A61N1/02 ,  A61N1/05

    CPC分类号： A61L31/06

    摘要： In one aspect, the present invention relates to a medical device, such as a medical electrical lead, comprising a biomaterial formed from a polymer comprising urethane groups and saturated linear polyethylene moieties wherein the saturated linear polethylene moieties have greater than 12 carbon atoms per moiety. In another aspect, the present invention relates medical devices comprising a biomaterial formed from segmented polymers or polymers having an elongation of greater than 50%. Exemplified polymers contain compounds of the formula HO—(CH2)n—OH wherein n is greater than 12.

    摘要翻译： 一方面，本发明涉及一种医疗装置，例如医用电导线，其包含由包含氨基甲酸酯基团和饱和线性聚乙烯部分的聚合物形成的生物材料，其中饱和直链极性亚乙基部分每个部分具有大于12个碳原子。 另一方面，本发明涉及包含由具有大于50％的伸长率的分段聚合物或聚合物形成的生物材料的医疗装置。 示例性聚合物含有式HO-（CH 2）n -OH的化合物，其中n大于12。