公开(公告)号：US6077852A

公开(公告)日：2000-06-20

申请号：US57723

申请日：1998-04-09

申请人： Kelly Renee Bales ,  Henry Uhlman Bryant ,  Steven Marc Paul ,  Mary Patricia Knadler

发明人： Kelly Renee Bales ,  Henry Uhlman Bryant ,  Steven Marc Paul ,  Mary Patricia Knadler

IPC分类号： C07D333/64 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4535 ,  A61K31/5377 ,  A61K31/55 ,  A61P25/24 ,  A61P25/28 ,  A01N43/40

CPC分类号： A61K31/5377 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4535 ,  A61K31/55 ,  Y10S514/878 ,  Y10S514/879

摘要： The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of the formula ##STR1## in which R.sup.1 and R.sup.2 are independently hydroxy and alkoxy of one to four carbon atoms; and R.sup.3 and R.sup.4 are independently methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.

公开(公告)号：US20100015155A1

公开(公告)日：2010-01-21

申请号：US12521309

申请日：2008-01-09

申请人： Kelly Renee Bales ,  Thomas Frank Bumol ,  Chi-Kin Chow ,  Ronald Bradley Demattos ,  Ryan John Hansen ,  Uma Kuchibhotla ,  Jirong Lu ,  Peter Colon McDonnell

发明人： Kelly Renee Bales ,  Thomas Frank Bumol ,  Chi-Kin Chow ,  Ronald Bradley Demattos ,  Ryan John Hansen ,  Uma Kuchibhotla ,  Jirong Lu ,  Peter Colon McDonnell

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P25/28

CPC分类号： C07K16/18 ,  A61K47/60 ,  A61K47/6893 ,  A61K2039/505 ,  A61K2039/6093 ,  B82Y5/00 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2319/31 ,  Y10S530/866

摘要： A method to treat conditions associated with Aβ peptide activity both prophylactically and therapeutically is described. The method employs humanized antibody fragments that specifically bind human Aβ peptide between amino acid positions 13-28, wherein the antibody fragments are covalently attached to a polyethylene glycol (PEG) molecule.

摘要翻译： 描述了一种治疗与预防和治疗双重肽活性相关的病症的方法。 该方法使用在氨基酸位置13-28之间特异性结合人Abeta肽的人源化抗体片段，其中抗体片段共价连接到聚乙二醇（PEG）分子上。