Vaginal treatment composition containing xylitol
    1.
    发明授权
    Vaginal treatment composition containing xylitol 有权
    含有木糖醇的阴道治疗组合物

    公开(公告)号:US07786176B2

    公开(公告)日:2010-08-31

    申请号:US11194064

    申请日:2005-07-29

    IPC分类号: A61K31/045

    摘要: A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

    摘要翻译: 提供了一种当与阴离子粘膜天然存在的单价或多价阳离子(例如钠(Na +)和钙(Ca 2+))阳离子接触时,迅速形成凝胶的阴道治疗组合物。 凝胶可以在小于约1小时,在一些实施方案中小于约1分钟,并且在一些实施方案中小于约30秒形成。 除此之外,这种快速凝胶化可降低使用过程中泄漏的可能性。 另外,因为凝胶可以阴道内形成,所以更可能在延长的时间段内保持其结构和形状。 以这种方式,凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如,凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

    Color-changing composition comprising a thermochromic ingredient
    3.
    发明申请
    Color-changing composition comprising a thermochromic ingredient 审中-公开
    变色组合物包含热变色成分

    公开(公告)号:US20060287215A1

    公开(公告)日:2006-12-21

    申请号:US11155353

    申请日:2005-06-17

    IPC分类号: C11D17/00

    摘要: Disclosed is a cleaning composition comprising a thermochromic ingredient that effects a color change at a given temperature or temperature range. Such a composition may be used to provide a signal, i.e., convey information, to a user of the cleaning composition, or a caregiver employing the cleaning composition. Additionally, the cleaning composition may be employed in a substrate, such as a nonwoven. The cleaning compositions may be used to provide a signal that helps improve cleaning effectiveness and/or safety and/or entertainment value. Furthermore, compositions comprising one or more thermochromic ingredients may be used to signify, or help induce, a given mental state, psychological state, or state of well being.

    摘要翻译: 公开了一种清洁组合物,其包含在给定温度或温度范围内实现颜色变化的热变色成分。 这样的组合物可用于向清洁组合物的使用者或使用清洁组合物的护理人员提供信号,即传送信息。 另外,清洁组合物可以用于基底如无纺布中。 清洁组合物可用于提供有助于提高清洁效果和/或安全性和/或娱乐价值的信号。 此外,包含一种或多种热变色成分的组合物可以用于表示或帮助诱导给定的精神状态,心理状态或健康状态。

    Visual indicator chronograph and the use of the same
    4.
    发明申请
    Visual indicator chronograph and the use of the same 有权
    视觉指标计时器和使用相同

    公开(公告)号:US20060114754A1

    公开(公告)日:2006-06-01

    申请号:US11000234

    申请日:2004-11-30

    IPC分类号: G04F1/00

    摘要: A timer indicator or chronograph is described. The chronograph functions according to chromatographic principles to develop a perceptible visual image or pattern on an indicator panel or display area, which serves as a means to monitor the relative amount of time that elapses. The chronograph includes a self-contained reservoir for an activating agent, which once activated creates a mobile front that traverses the indicator panel substrate from the reservoir to a distal end at a predetermined rate. The chronograph may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as either a training aid or as a dryness indicator. Methods for using and making the chronograph are also described.

    摘要翻译: 描述了定时器指示器或计时码表。 计时码表根据色谱原理起作用,以在显示面板或显示区域上形成一个可察觉的视觉图像或图案,这是监测经过的相对时间量的一种手段。 计时码表包括用于激活剂的独立储存器,其一旦被激活就产生以预定速率从储存器穿过指示器面板基底到远端的移动前部。 计时码表可以用作独立设备,也可以作为各种物品或产品的一部分来使用,例如作为训练助剂或干燥指示剂。 还描述了使用和制造计时码表的方法。

    Vaginal treatment composition
    6.
    发明申请
    Vaginal treatment composition 有权
    阴道治疗组合物

    公开(公告)号:US20070026074A1

    公开(公告)日:2007-02-01

    申请号:US11194064

    申请日:2005-07-29

    IPC分类号: A61K9/14 A61K31/70 A61K31/045

    摘要: A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

    摘要翻译: 当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物,例如天然存在的钠(Na +)+和钙(Ca 2+)+阳离子 提供阴道粘膜。 凝胶可以在小于约1小时,在一些实施方案中小于约1分钟,并且在一些实施方案中小于约30秒形成。 除此之外,这种快速凝胶化可降低使用过程中泄漏的可能性。 另外,因为凝胶可以阴道内形成,所以更可能在延长的时间段内保持其结构和形状。 以这种方式,凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如,凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

    Xylitol for treatment of vaginal infections
    7.
    发明授权
    Xylitol for treatment of vaginal infections 失效
    木糖醇用于治疗阴道感染

    公开(公告)号:US07619008B2

    公开(公告)日:2009-11-17

    申请号:US11194039

    申请日:2005-07-29

    IPC分类号: A61K31/045

    摘要: A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.

    摘要翻译: 提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。 治疗剂能够抑制和/或杀死加德纳(Gardnerella vaginalis),念珠菌(例如白色念珠菌)和/或滴虫(例如阴道毛滴虫)病原体。 理想地,实现了这样的抗微生物效能,而基本上不抑制嗜酸乳杆菌的生长。 例如,本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。 在一个具体实施方案中,D-木糖醇用作治疗剂。

    Color changing skin sealant
    8.
    发明申请
    Color changing skin sealant 审中-公开
    变色皮肤密封剂

    公开(公告)号:US20080063615A1

    公开(公告)日:2008-03-13

    申请号:US11590626

    申请日:2006-10-31

    IPC分类号: A61K8/22

    CPC分类号: A61L24/001

    摘要: Iodine is used in about 80 percent of surgeries in the US to remove some level of microbial load on the skin prior to making an incision. Skin sealants are applied over skin preps to seal the skin and hold any remaining bacteria in place. Iodine produces a characteristic orange-brown color on skin. A skin sealant is provided that has a decolorant that reacts with the iodine found in most skin preps, rendering the skin prep colorless. A skin sealant containing ascorbic acid (vitamin C), Indigo Carmine or Indigo will react with the iodine, thus visually indicating where the skin prep and sealant have been applied and allowing an unobstructed view of the incision.

    摘要翻译: 在美国约80%的手术中使用碘,以在切开前去除皮肤上的一定程度的微生物负荷。 将皮肤密封剂涂于皮肤上,以密封皮肤并将任何残留的细菌保持在适当的位置。 碘在皮肤上产生特征橙棕色。 提供具有与大多数皮肤前食中发现的碘反应的脱色剂的皮肤密封剂,使得皮肤无色。 含有抗坏血酸(维生素C),靛蓝胭脂红或靛蓝的皮肤密封剂将与碘反应,从而可视地显示出皮肤制剂和密封剂的使用位置,并允许切口无阻碍地观察。

    Color changing skin sealant with co-acid trigger
    9.
    发明申请
    Color changing skin sealant with co-acid trigger 审中-公开
    变色皮肤密封剂与co酸触发

    公开(公告)号:US20080060550A1

    公开(公告)日:2008-03-13

    申请号:US11642359

    申请日:2006-12-19

    IPC分类号: A61Q19/00

    CPC分类号: A61L24/001 C09D4/00

    摘要: Skin sealants are applied over skin preps to seal the skin and hold any remaining bacteria in place prior to incisions. It is desirable for the person applying the sealant to know where the sealant has been applied. It is also desirable to be able so see through the sealant to observe the skin to detect any possible infection. A skin sealant is provided that has a pH indicator and co-additive acid that react soon after mixing, rendering the skin prep colorless.

    摘要翻译: 将皮肤密封剂施用于皮肤制服上以密封皮肤,并在切口之前将任何剩余的细菌保持在适当位置。 施加密封剂的人员最好知道已经施加了密封剂的位置。 还希望通过密封剂能够观察皮肤以检测任何可能的感染。 提供一种具有pH指示剂和共添加酸的表皮密封剂,其在混合后不久反应,使皮肤无色。

    Visual indicator chronograph and the use of the same
    10.
    发明申请
    Visual indicator chronograph and the use of the same 审中-公开
    视觉指标计时器和使用相同

    公开(公告)号:US20080025154A1

    公开(公告)日:2008-01-31

    申请号:US11890683

    申请日:2007-08-07

    IPC分类号: G04F1/00 G01D21/00

    摘要: A timer indicator or chronograph is described. The chronograph functions according to chromatographic principles to develop a perceptible visual image or pattern on an indicator panel or display area, which serves as a means to monitor the relative amount of time that elapses. The chronograph includes a self-contained reservoir for an activating agent, which once activated creates a mobile front that traverses the indicator panel substrate from the reservoir to a distal end at a predetermined rate. The chronograph may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as either a training aid or as a dryness indicator. Methods for using and making the chronograph are also described.

    摘要翻译: 描述了定时器指示器或计时码表。 计时码表根据色谱原理起作用,以在显示面板或显示区域上形成一个可察觉的视觉图像或图案,这是监测经过的相对时间量的一种手段。 计时码表包括用于激活剂的独立储存器,其一旦被激活就产生以预定速率从储存器穿过指示器面板基底到远端的移动前部。 计时码表可以用作独立设备,也可以作为各种物品或产品的一部分来使用,例如作为训练助剂或干燥指示剂。 还描述了使用和制造计时码表的方法。