公开(公告)号：US4082070A

公开(公告)日：1978-04-04

申请号：US623051

申请日：1975-10-16

Applicant: Helmut Saufferer ,  Karl Willmann

Inventor： Helmut Saufferer ,  Karl Willmann

IPC: B05B5/043 ,  F02M27/04 ,  F02B33/00

CPC classification number: B05B5/043 ,  F02M27/04 ,  F02B2275/14 ,  Y10S261/39

Abstract: Apparatus for the conveyance and atomization of a liquid including at least one nozzle directed toward an atomizing chamber, a pressure source or reservoir providing a conveying pressure for the liquid, a fluid-dynamic connection connecting the nozzle and the pressure source or reservoir, and an electrode disposed a predetermined distance in front of the nozzle. At least a portion of the nozzle is formed of an electrically conductive material and is electrically insulated at least with respect to the electrode. A difference in potential is applied between the electrically conductive portion of the nozzle and the electrode during an atomizing period, whereby liquid discharged from the nozzle is atomized.

公开(公告)号：US20200254118A1

公开(公告)日：2020-08-13

申请号：US15776351

申请日：2016-12-02

Applicant: Sunitha Bachawal ,  Juergen Karl Willmann

Inventor： Sunitha Bachawal ,  Juergen Karl Willmann

IPC: A61K49/22 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61P35/00 ,  A61P31/00

Abstract: Compositions and methods for detection and diagnosis of breast cancer are disclosed. In particular, the invention relates to the use of B7-H3-targeted imaging agents for molecular imaging of breast cancer. Vascular expression of B7-H3 is selectively and significantly higher in breast cancer tissues. Detection of B7-H3 can be used to distinguish between benign and malignant lesions with high diagnostic accuracy. B7-H3-targeted imaging agents can be produced by conjugation of a B7-H3-binding antibody, aptamer, or other ligand to various diagnostic agents, such as contrast agents, photoactive agents, or detectable labels that are useful for detection and medical imaging of breast cancer tumors.

公开(公告)号：US4085717A

公开(公告)日：1978-04-25

申请号：US684194

申请日：1976-05-07

Applicant: Karl Willmann ,  Helmut Saufferer

Inventor： Karl Willmann ,  Helmut Saufferer

IPC: F02M15/02 ,  F02M27/04 ,  F23R3/28 ,  F02B51/04 ,  F02M29/00

CPC classification number: F02M27/04 ,  Y10S261/80

Abstract: An atomization system for internal combustion engines for atomizing fuel in an air stream, which includes an atomization space separate from the combustion or working space of the internal combustion engine and traversed at least in part by the combustion air; the electrically conductive fuel supply includes a large number of small capillary tubes projecting into the atomization space from the mounting support thereof while a counter-electrode is provided with a large surface facing the discharge openings of the capillary tubes; additionally, means are provided for guiding the air in such a direction and at such a velocity that the forces exerted on the atomized and electrically charged fuel droplets by the flowing air predominate the electrostatic attracting forces exerted on the droplets by the counter-electrode and thus keep the droplets from the counter-electrode.

Abstract translation: 一种用于在空气流中雾化燃料的内燃机的雾化系统，其包括与内燃机的燃烧或工作空间分离并至少部分由燃烧空气穿过的雾化空间; 导电燃料供给包括从其安装支撑件突出到雾化空间中的大量小毛细管，而对电极设置有面对毛细管的排出口的大表面; 此外，提供了用于沿着这样一个方向和速度引导空气的装置，使得由流动的空气施加在雾化和带电的燃料液滴上的力主要由对电极施加在液滴上的静电吸引力 保持液滴从对电极。

公开(公告)号：US20210340257A1

公开(公告)日：2021-11-04

申请号：US17267733

申请日：2019-08-22

Applicant: Lotfi Abou-Elkacem ,  Juergen Karl Willmann ,  Benjamin J. Hackel ,  Lawrence Arthur Stern ,  Patrick Samuel Lown ,  Amelie Margarete Marianne Lutz ,  Rakesh Kumar Bam ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Lotfi Abou-Elkacem ,  Juergen Karl Willmann ,  Benjamin J. Hackel ,  Lawrence Arthur Stern ,  Patrick Samuel Lown ,  Amelie Margarete Marianne Lutz ,  Rakesh Kumar Bam

IPC: C07K16/28 ,  A61K47/68 ,  A61K49/22 ,  A61K9/00 ,  A61P35/00

Abstract: Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity. The affibodies can be conjugated to contrast agents, including without limitation microbubbles for contrast-enhanced ultrasound imaging

公开(公告)号：US4091779A

公开(公告)日：1978-05-30

申请号：US635752

申请日：1975-11-28

Applicant: Helmut Saufferer ,  Karl Willmann

Inventor： Helmut Saufferer ,  Karl Willmann

IPC: F02M27/04 ,  B01J19/08 ,  F02B1/04 ,  F02B3/06 ,  F02B51/04 ,  F02B75/12 ,  F23C99/00 ,  F23B7/00

CPC classification number: F23C99/001 ,  F02B51/04 ,  F02B1/04 ,  F02B2075/125 ,  F02B3/06 ,  Y02T10/123 ,  Y02T10/126

Abstract: A method and apparatus for influencing thermo-chemical reactions by means of an electric field, in which the ions formed by the reaction itself are directed by the application of the electric field in order to control the further reaction progress.

Abstract translation: 通过电场影响热化学反应的方法和装置，其中由反应本身形成的离子通过施加电场来引导，以便控制进一步的反应进程。

公开(公告)号：US4034728A

公开(公告)日：1977-07-12

申请号：US539830

申请日：1975-01-09

Applicant: Helmut Saufferer ,  Karl Willmann

Inventor： Helmut Saufferer ,  Karl Willmann

IPC: F02M27/04 ,  F02B51/04

CPC classification number: F02M27/04 ,  Y10S261/39 ,  Y10S261/80

Abstract: An installation for producing an air/fuel mixture for a mixture-aspirating internal combustion engine, which includes a fuel atomizer equipped with at least one fuel nozzle terminating in the air guide channel and traversed by the sucked-in air; certain surfaces arranged in the flow path of the mixture are thereby at different electric potentials whereby an electrode electrically insulated with respect to the fuel nozzle or nozzles is arranged in front of each of the nozzles with the potential difference applied between the electrode, on the one hand, and the fuel nozzle on the other.

Abstract translation: 一种用于生产用于混合物 - 抽吸式内燃机的空气/燃料混合物的装置，其包括装备有至少一个燃料喷嘴的燃料雾化器，燃料喷嘴终止于空气引导通道并被吸入的空气穿过; 因此，在混合物的流动路径中布置的某些表面具有不同的电位，由此相对于燃料喷嘴或喷嘴电绝缘的电极布置在每个喷嘴的前面，其中施加在电极之间的电位差 手和燃料喷嘴在另一个。

公开(公告)号：US4077374A

公开(公告)日：1978-03-07

申请号：US677863

申请日：1976-04-16

Applicant: Karl Willmann ,  Helmut Saufferer

Inventor： Karl Willmann ,  Helmut Saufferer

IPC: F02M27/04 ,  F02M51/06 ,  F02M51/08 ,  F02M57/00 ,  F02M61/08 ,  F02M69/04 ,  F02M47/00 ,  B05B5/00

CPC classification number: F02M57/00 ,  F02M61/08

Abstract: An injection valve for internal combustion engines with a valve member forced against its valve seat opposite the injection direction by a spring force and adapted to be lifted off from the valve seat in the injection direction by the hydraulic pressure in the fuel liquid to be injected, and in which the fuel liquid is adapted to be sprayed off in the form of a spray cone; the valve seat is thereby arranged at the end of an electrically conductive tubular spacer member electrically conductively connected with the valve housing and projecting from the valve housing; the outer diameter of the tubular spacer member is thereby considerably smaller than a characteristic valve housing dimension within the area of the connecting place of the spacer member with the valve housing while an annular electrode is arranged at a spacing about the discharge place of the valve which is electrically insulated with respect to the valve housing and the spacer member; the front end edge of the annular electrode, as viewed in the injection direction, has a larger spacing from the valve housing than from the spacer member while its rear end edge lies outside of the spray cone; an electrical potential is applied to the annular electrode with respect to the valve housing.

Abstract translation: 一种用于内燃机的喷射阀，其中阀构件通过弹簧力而被迫抵靠其阀座与喷射方向相反，并且适于通过待喷射的燃料液体中的液压在喷射方向上从阀座上离开， 并且其中燃料液体适于以喷雾锥体的形式被喷射; 因此，阀座布置在与阀壳体导电连接并从阀壳体突出的导电管状间隔件的端部处; 因此，管状间隔件的外径远远小于在具有阀壳体的间隔件的连接位置的区域内的特征阀壳体尺寸，而环形电极以围绕阀的排放位置的间隔布置 相对于阀壳体和间隔件电绝缘; 从注射方向看，环形电极的前端边缘与阀壳体的距离大于间隔件的间隔，而其后端边缘位于喷雾锥体的外侧; 相对于阀壳体将电位施加到环形电极。