公开(公告)号：US20130053276A1

公开(公告)日：2013-02-28

申请号：US13508540

申请日：2010-09-24

申请人： Frank Klein ,  Thomas Weigel ,  Karl Kratz ,  Friedrich Jung ,  Bernhard Hiebl ,  Andreas Lendlein ,  Karola Lützow ,  Andreas Kurtz ,  Petra Reinke ,  Andy Römhild

发明人： Frank Klein ,  Thomas Weigel ,  Karl Kratz ,  Friedrich Jung ,  Bernhard Hiebl ,  Andreas Lendlein ,  Karola Lützow ,  Andreas Kurtz ,  Petra Reinke ,  Andy Römhild

IPC分类号： C40B30/06 ,  C40B40/00

CPC分类号： G01N33/5008

摘要： The present invention relates to a method for testing different selected materials and/or surface structures for the culture of cells and/or microorganisms, said method comprising the following steps: i) providing a plurality of different selected materials and/or surface structures to be tested in the form of beaker-shaped inserts, wherein the beaker-shaped inserts are dimensioned in such a way that a beaker-shaped insert can be inserted in a substantially accurately fitting manner into a well of a multiwell plate suitable for cell culture, wherein each beaker-shaped insert has walls, a base, and an opening in the side facing away from the base, wherein the walls and base of the beaker-shaped inserts are liquid-tight, and wherein each beaker-shaped insert has a selected material and/or a selected surface structure, at least on the inner face of the base; ii) inserting the beaker-shaped inserts into wells of multiwell plates of appropriate dimensioning so that the outer face of the beaker base points towards the inner face of the base of a well of the multiwell plate; iii) culturing the cells in the lumen of the beaker-shaped inserts, and to a kit for carrying out this method.

摘要翻译： 本发明涉及一种用于测试用于培养细胞和/或微生物的不同选择的材料和/或表面结构的方法，所述方法包括以下步骤：i）提供多种不同的选择的材料和/或表面结构为 以烧杯形插入物的形式进行测试，其中烧杯形插入件的尺寸设计使得可将烧杯形插入件以基本上精确适合的方式插入适合于细胞培养的多孔板的孔中，其中 每个烧杯形插件具有壁，基部和在背离基部的一侧的开口，其中烧杯形插入件的壁和底部是液密的，并且其中每个烧杯形插入件具有选定的材料 和/或选定的表面结构，至少在基底的内表面上; ii）将所述烧杯形插入物插入适合尺寸的多孔板的孔中，使得所述烧杯基底的外表面指向所述多孔板的孔的底部的内表面; iii）在烧杯形插入物的内腔中培养细胞，以及用于实施该方法的试剂盒。

公开(公告)号：US20080305545A1

公开(公告)日：2008-12-11

申请号：US12081104

申请日：2008-04-10

申请人： Andreas Lendlein ,  Ralf Knischka ,  Karl Kratz

发明人： Andreas Lendlein ,  Ralf Knischka ,  Karl Kratz

IPC分类号： C12N5/06

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/38 ,  B29C61/06 ,  B29K2995/006 ,  C08L67/04 ,  C08L2201/12 ,  C08L101/00

摘要： Methods and compositions are described herein for reconstruction of different functional tissues. Dissociated cells, differentiated cells, adult mesenchymal stem cells or embryonic stem cells are seeded on a scaffold. The scaffold will consist of a biocompatible, biodegradable shape memory (“SM”) polymers. In addition bioactive substances may be incorporated in the scaffold. Thermoplastic as well as thermoset materials with SM-effect can be used. The shape memory effect will be applied as an interactive link between the cells and the used polymeric scaffold. The degradation kinetics as well as shape memory transition temperature will be tailored by adjusting to monomer ratios of the co-oligomers. The shape memory effect will be used to create a degradation or release of bioactive substances on demand, induce forces on seeded cells or induce proliferation and differentiation of cells.

摘要翻译： 本文描述了用于重建不同功能组织的方法和组合物。 将解离的细胞，分化细胞，成体间充质干细胞或胚胎干细胞接种在支架上。 支架将由生物相容的，可生物降解的形状记忆（“SM”）聚合物组成。 此外，生物活性物质可以并入支架中。 可以使用热塑性以及具有SM效应的热固性材料。 形状记忆效应将被用作细胞和使用的聚合物支架之间的交互式连接。 降解动力学以及形状记忆转变温度将通过调节共低聚物的单体比来调整。 形状记忆效应将用于根据需要产生生物活性物质的降解或释放，诱导种子细胞的力或诱导细胞的增殖和分化。

公开(公告)号：US20060140892A1

公开(公告)日：2006-06-29

申请号：US10511019

申请日：2003-04-10

申请人： Andreas Lendlein ,  Werner Grasser ,  Karl Kratz ,  Thomas Krause ,  Exel Kalbfleisch ,  Gunther Lang ,  Jurgen Allwohn ,  Johannes Burghaus ,  Gerhard Sendelbach ,  Detlef Mattinger ,  Stefan Uhl

发明人： Andreas Lendlein ,  Werner Grasser ,  Karl Kratz ,  Thomas Krause ,  Exel Kalbfleisch ,  Gunther Lang ,  Jurgen Allwohn ,  Johannes Burghaus ,  Gerhard Sendelbach ,  Detlef Mattinger ,  Stefan Uhl

IPC分类号： A61K8/81

CPC分类号： A61K8/046 ,  A61K8/416 ,  A61K8/8152 ,  A61K8/8182 ,  A61K8/86 ,  A61K8/88 ,  A61K2800/594 ,  A61Q5/06

摘要： Disclosed is a method for achieving a recallable hair deformation. A composition is applied onto hair, comprising at least one active agent, which, alone or in combination with further compounds, is able, after application to the hair and after carrying out the treatment of hair in accordance with the present invention, to provide a shape memory effect. The hair is brought into a defined (permanent) shape and the permanent shape is subsequently fixed by means of inducing a chemical or physical change of the applied agents, wherein after a desired or undesired deformation, the memory shape of the initial memory shape may be recovered by means of a physical stimulation. Suitable active agents are for example macromers which may be cross-linked to provide shape memory polymers, wherein the permanent shape is fixed by means of the chemical cross-linking of the macromer, providing a shape memory polymer, which possesses at least one transition temperature Ttrans. Suitable active agents are also shape memory polymers, which have hard segments which may be cross-linked by physical interactions having a first transition temperature T′trans, which preferably is at least 10° C. above room temperature, and soft segments having a second transition temperature which preferably is at least 10° C. below T′trans. In addition to the permanent hairdo, a second (temporary) shape can be impressed. Furthermore, disclosed is a method for the recovery of a once programmed permanent hairdo, which has been brought into a temporary shape or which has been deformed in any other way.

摘要翻译： 公开了一种实现可召回的头发变形的方法。 将组合物施用到头发上，其包含至少一种活性剂，其单独或与其他化合物组合可以在施用到毛发之后以及在进行根据本发明的毛发处理之后提供一种 形状记忆效应。 头发被带入限定的（永久）形状，并且随后通过引起所施加的药剂的化学或物理变化来固定永久形状，其中在所需或不期望的变形之后，初始记忆形状的记忆形状可以是 通过物理刺激恢复。 合适的活性剂是例如可以交联以提供形状记忆聚合物的大分子单体，其中永久形状通过大分子单体的化学交联固定，提供形状记忆聚合物，其具有至少一个转变温度 T 。 合适的活性剂也是形状记忆聚合物，其具有可通过物理相互作用交联的硬链段，其具有第一转变温度T'反式，优选在室温以上至少10℃ ，和具有第二转变温度的软链段，其优选在T'反式以下至少10℃。 除了永久发型，第二（暂时）形状可以印象深刻。 此外，公开了一种用于恢复已经被暂时形成或以任何其它方式变形的一次编程的永久性发型的方法。

公开(公告)号：US09272464B2

公开(公告)日：2016-03-01

申请号：US12808876

申请日：2008-12-16

申请人： Karl Kratz ,  Andreas Lendlein ,  Reinhard Mohr ,  Marc Behl

发明人： Karl Kratz ,  Andreas Lendlein ,  Reinhard Mohr ,  Marc Behl

IPC分类号： B32B7/02 ,  B29C67/24 ,  H05B6/02 ,  B29C61/06 ,  B29C61/00 ,  B29C35/08 ,  B29K105/16

CPC分类号： B29C61/0608 ,  B29C61/00 ,  B29C2035/0811 ,  B29C2791/001 ,  B29K2105/16 ,  Y10T428/24942

摘要： The invention relates to an article (10) made of a shape memory composite material (12) comprising a shape memory polymer (14) and a magnetic material (16) embedded therein, said shape memory polymer (14) after thermomechanical programming being capable of undergoing at least one temperature-induced transition from a temporary shape into a permanent shape, as well as to a method for the production thereof and a method for retrieving stored shapes.It is envisaged that the article (10) has at least two directly or indirectly interconnected sections (18, 20) which differ by a different surface-to-volume ratio (S/V).

摘要翻译： 本发明涉及一种由形状记忆复合材料（12）制成的制品（10），所述形状记忆复合材料包括形状记忆聚合物（14）和嵌入其中的磁性材料（16），所述形状记忆聚合物（14）在热机械编程之后能够 经历从临时形状到永久形状的至少一个温度诱导的转变，以及其生产方法和用于检索存储的形状的方法。 设想物品（10）具有由不同的表面与体积比（S / V）不同的至少两个直接或间接互连的部分（18,20）。

公开(公告)号：US20120018922A1

公开(公告)日：2012-01-26

申请号：US13092761

申请日：2011-04-22

申请人： Karl Kratz ,  Andreas Lendlein ,  Ulrike Voigt ,  Wolfgang Wagermaier

发明人： Karl Kratz ,  Andreas Lendlein ,  Ulrike Voigt ,  Wolfgang Wagermaier

IPC分类号： B29C51/00 ,  B29C67/00 ,  B29C67/24 ,  B29C67/20

CPC分类号： B29C61/06 ,  B29K2067/00

摘要： The invention relates to a method for programming a shape memory polymer, which comprises at least one switching segment having at least one thermal phase transition and covalent and/or non-covalent cross-linking points such that the shape memory polymer after the programming thereof is in a position to transition from a programmed temporary shape into the permanent shape thereof, following a temperature increase to a temperature that at least corresponds to a switching temperature (Tswitch, Tσmax). According to the invention, the method comprises (a) predetermining a programming temperature (tprog) as a function of a desired switching temperature (Tswitch, Tσmax), (b) heating the shape memory polymer to the predetermined programming temperature (tprog), and transferring the polymer into a shape that corresponds to the temporary shape by applying a forced molding state, and (c) cooling the polymer to a temperature below the desired switching temperature (Tswitch, Tσmax) while maintaining the forced molding state.

摘要翻译： 本发明涉及一种用于编程形状记忆聚合物的方法，该方法包括至少一个具有至少一个热相变和共价和/或非共价交联点的切换片段，使得其编程之后的形状记忆聚合物是 处于从编程的临时形状转变为其永久形状的位置，随着温度升高至至少对应于开关温度（Tswitch，T＆Sgr max）的温度。 根据本发明，该方法包括：（a）根据期望的开关温度（Tswitch，T＆sgr; max）预先确定编程温度（tprog），（b）将形状记忆聚合物加热到预定的编程温度（tprog） 并且通过施加强制成型状态将聚合物转移到对应于临时形状的形状，和（c）在保持强制成型状态的同时将聚合物冷却至低于所需切换温度（Tswitch，T＆Sgr max）的温度。

公开(公告)号：US20080311050A1

公开(公告)日：2008-12-18

申请号：US10566230

申请日：2004-07-14

申请人： Andreas Lendlein ,  Tareq Ali Abdulla Hasson ,  Karl Kratz ,  Leonid Kuper ,  Thomas Krause ,  Axel Kalbfleisch ,  Anja Duchscherer ,  Angelika Beyer

发明人： Andreas Lendlein ,  Tareq Ali Abdulla Hasson ,  Karl Kratz ,  Leonid Kuper ,  Thomas Krause ,  Axel Kalbfleisch ,  Anja Duchscherer ,  Angelika Beyer

IPC分类号： A61K8/06 ,  A61K9/107 ,  A61Q5/04

CPC分类号： A61K8/891 ,  A61K8/8152 ,  A61K8/86 ,  A61K8/87 ,  A61K8/892 ,  A61K2800/54 ,  A61Q5/06

摘要： A method for achieving a retrievable hair restyling is described. Here a composition is applied to the hair, said composition containing at least one first active ingredient or active ingredient complex which can provide a shape memory effect by itself or in combination with other substances after being applied to the hair and after the performance of the treatment of the hair according to the invention. The composition additionally contains at least one second active ingredient, namely a hydrophobic substance with a water solubility of ≦5 percent by weight at 20° C. The hair is arranged into a given (permanent) shape and said permanent shape is then fixed by inducing a chemical or physical modification of the applied active ingredients, wherein after a wanted or unwanted deformation of the shape memory, the original shape memory can be restored by means of a physical stimulation. In addition to the permanent hairstyle, a second (temporary) shape can be impressed. A method is also described for restoring a previously programmed permanent hairstyle that was temporarily transformed into a temporary shape or that was otherwise deformed.

摘要翻译： 描述了一种用于实现可回收毛发修复的方法。 这里将组合物施用于毛发，所述组合物含有至少一种第一活性成分或活性成分复合物，其可以在施用于毛发后自身或与其它物质组合提供形状记忆效应，并且在进行处理之后 的根据本发明的头发。 该组合物另外含有至少一种第二活性成分，即在20℃下水溶性为<= 5重量％的疏水性物质。毛发排列成给定（永久）形状，然后将所述永久形状固定在 诱导所施加的活性成分的化学或物理改性，其中在形状记忆体的想要或不期望的变形之后，可以通过物理刺激来恢复原始形状记忆。 除了永久发型之外，还可以留下第二（暂时）形状。 还描述了一种用于恢复临时转变成临时形状或以其他方式变形的先前编程的永久性发型的方法。

公开(公告)号：US20070009465A1

公开(公告)日：2007-01-11

申请号：US10566231

申请日：2004-07-14

申请人： Andreas Lendlein ,  Tareq Ali Abdulla Hasson ,  Karl Kratz ,  Simone Moersheim ,  Yasmin Ghazlan ,  Susanne Birkel ,  Thomas Krause ,  Axel Kalbfleisch ,  Andrea Walter ,  Susanne Granner

发明人： Andreas Lendlein ,  Tareq Ali Abdulla Hasson ,  Karl Kratz ,  Simone Moersheim ,  Yasmin Ghazlan ,  Susanne Birkel ,  Thomas Krause ,  Axel Kalbfleisch ,  Andrea Walter ,  Susanne Granner

IPC分类号： A61K8/84

CPC分类号： C08G63/664 ,  A61K8/90 ,  A61K2800/54 ,  A61Q5/06 ,  C08G2261/126

摘要： A cosmetic composition is described, said composition having a content of a block polymer having at least a first block, which block is a polyol selected from polyethers, dimerdiol, derivatives derived from dimerdiol and polyesters of dicarboxylic acids with diols and at least two additional blocks, which blocks are polyesters of hydroxycarboxylic acids or lactones thereof.

摘要翻译： 描述了一种化妆品组合物，所述组合物具有至少具有第一嵌段的嵌段聚合物的含量，该嵌段是选自聚醚，二聚二醇，衍生自二聚二醇的衍生物和二羧酸与二醇的聚酯和至少两个附加嵌段的多元醇 ，哪些嵌段是羟基羧酸或其内酯的聚酯。

公开(公告)号：US09726660B2

公开(公告)日：2017-08-08

申请号：US13508540

申请日：2010-09-24

申请人： Frank Klein ,  Thomas Weigel ,  Karl Kratz ,  Friedrich Jung ,  Bernhard Hiebl ,  Andreas Lendlein ,  Karola Lützow ,  Andreas Kurtz ,  Petra Reinke ,  Andy R•mhild

发明人： Frank Klein ,  Thomas Weigel ,  Karl Kratz ,  Friedrich Jung ,  Bernhard Hiebl ,  Andreas Lendlein ,  Karola Lützow ,  Andreas Kurtz ,  Petra Reinke ,  Andy R•mhild

IPC分类号： C40B30/06 ,  C40B40/00 ,  G01N33/50

CPC分类号： G01N33/5008

摘要： The present invention relates to a method for testing different selected materials and/or surface structures for the culture of cells and/or microorganisms.

公开(公告)号：US08697835B2

公开(公告)日：2014-04-15

申请号：US13092400

申请日：2011-04-22

申请人： Andreas Lendlein ,  Narendra Kumar Uttamchand ,  Karl Kratz ,  Marc Behl

发明人： Andreas Lendlein ,  Narendra Kumar Uttamchand ,  Karl Kratz ,  Marc Behl

IPC分类号： C08F6/00

CPC分类号： B29C61/0625

摘要： A method for restoring a programmed article which contains a shape memory composite material of at least one shape memory polymer network with thermally inducible triple shape properties, the method comprising subjecting the article to a magnetic alternating field and simultaneously to an external heat supply in order to trigger the restoration, wherein at least one of the parameters of magnetic field strength (H) and ambient temperature (TUmg) is increased continuously or discontinuously in such a way that the article first experiences a transition in shape from the first temporary shape (TF1) into the second temporary shape (TF2) and subsequently from the second temporary shape (TF2) into the permanent shape (PF).

摘要翻译： 一种用于恢复编程物品的方法，所述方法包含具有热诱导性三重形状性质的至少一种形状记忆聚合物网络的形状记忆复合材料，所述方法包括使物品经受磁场交替场，同时进行外部供热，以便 触发恢复，其中磁场强度（H）和环境温度（TUmg）的参数中的至少一个连续地或不连续地增加，使得制品首先经历从第一临时形状（TF1）的形状转变， 进入第二临时形状（TF2），随后从第二临时形状（TF2）变成永久形状（PF）。

公开(公告)号：US20110258826A1

公开(公告)日：2011-10-27

申请号：US13092400

申请日：2011-04-22

申请人： Andreas Lendlein ,  Narendra Kumar Uttamchand ,  Karl Kratz ,  Marc Behl

发明人： Andreas Lendlein ,  Narendra Kumar Uttamchand ,  Karl Kratz ,  Marc Behl

IPC分类号： B23P6/00

CPC分类号： B29C61/0625

摘要： The invention relates to a method for restoring a programmed article which contains, at least over portions, a shape memory composite material, said composite material comprising (i) at least one shape memory polymer network with thermally inducible triple shape properties which comprises at least one first phase-separated switching segment with a first transition temperature (Ttrans,1) and a second phase-separated switching segment with a second transition temperature (Ttrans,2, where Ttrans,1

摘要翻译： 本发明涉及一种用于恢复编程制品的方法，所述方法至少包含以下部分：形状记忆复合材料，所述复合材料包括（i）至少一种具有热诱导性三重形状特征的形状记忆聚合物网络，其包括至少一个 具有第一转变温度（Ttrans，1）的第一相分离开关段和具有第二转变温度（Ttrans，2，其中Ttrans，1