HEMATOPOIETIC PRECURSOR CELL PRODUCTION BY PROGRAMMING
    1.
    发明申请
    HEMATOPOIETIC PRECURSOR CELL PRODUCTION BY PROGRAMMING 有权
    HEMATOPOIETIC PRECURSOR细胞生产编程

    公开(公告)号:US20140037600A1

    公开(公告)日:2014-02-06

    申请号:US13984281

    申请日:2012-02-07

    IPC分类号: C12N5/0789 A61K35/28

    摘要: The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.

    摘要翻译: 本发明通常涉及用于从多种细胞来源例如多能干细胞或体细胞提供造血细胞和造血细胞前体的方法。 还提供了治疗组合物,包括所提供的造血细胞和造血细胞的前体,以及用于治疗受试者的方法。

    EPISOMAL REPROGRAMMING WITH CHEMICALS
    7.
    发明申请
    EPISOMAL REPROGRAMMING WITH CHEMICALS 有权
    与化学品的异构化

    公开(公告)号:US20110104125A1

    公开(公告)日:2011-05-05

    申请号:US12939454

    申请日:2010-11-04

    申请人: JUNYING YU

    发明人: JUNYING YU

    摘要: Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.

    摘要翻译: 公开了诱导多能干细胞的方法和组成。 例如,在某些方面,描述了用细胞信号调节剂产生基本上无载体的诱导多能干细胞的方法。 此外,本发明的某些方面提供了包含在包含信号传导抑制剂的培养基存在下基本上不含外源性逆转录病毒载体元件的诱导多能干细胞的新型组合物。 在某些方面,可以提供无饲料的游离重编程方法。