公开(公告)号：US07767693B2

公开(公告)日：2010-08-03

申请号：US12427847

申请日：2009-04-22

Applicant: Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

Inventor： Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

IPC: A01N43/40 ,  C07D211/22 ,  C07C49/303

CPC classification number: C07D211/42 ,  A61K31/12 ,  A61K31/165 ,  A61K31/216 ,  A61K31/40 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  C07C49/84 ,  C07C69/738 ,  C07C205/45 ,  C07C235/78 ,  C07D207/08 ,  C07D207/12 ,  C07D207/27 ,  C07D211/22 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/50 ,  C07D217/06 ,  C07D239/42 ,  C07D241/08 ,  C07D295/088 ,  C07D295/185 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D317/60 ,  C07D333/22 ,  C07D333/24 ,  C07D409/10

Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.

Abstract translation: 本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基 ，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的 未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上 所述苯甲酰化合物或所述前药的可接受的盐。

公开(公告)号：US20060058366A1

公开(公告)日：2006-03-16

申请号：US10536881

申请日：2003-12-03

Applicant: Fumihiko Kanai ,  Toshiaki Kumazawa ,  Jun-ichi Saito ,  Junichi Shimada ,  Ryo Hirose ,  Michio Ichimura

Inventor： Fumihiko Kanai ,  Toshiaki Kumazawa ,  Jun-ichi Saito ,  Junichi Shimada ,  Ryo Hirose ,  Michio Ichimura

IPC: A61K31/416 ,  C07D231/56

CPC classification number: A61K31/4439 ,  A61K31/416 ,  A61K31/444 ,  A61K31/497 ,  C07D231/56 ,  C07D401/06

Abstract: The present invention provides a JNK inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I) [wherein R1 represents substituted or unsubstituted aryl or the like and R2 represents a hydrogen atom, NR3R4 (wherein R3 and R4 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkanoyl or the like), carboxy, lower alkenyl or the like] or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供一种JNK抑制剂，其包含作为活性成分的式（I）表示的吲唑衍生物，

公开(公告)号：US20090247522A1

公开(公告)日：2009-10-01

申请号：US12427847

申请日：2009-04-22

Applicant: Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

Inventor： Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

IPC: A61K31/5377 ,  A61K31/12 ,  A61K31/216 ,  A61K31/165 ,  A61K31/44 ,  A61K31/495 ,  A61K31/445 ,  A61K31/40 ,  A61K31/496 ,  A61K31/47 ,  A61K31/5375 ,  A61P35/00

CPC classification number: C07D211/42 ,  A61K31/12 ,  A61K31/165 ,  A61K31/216 ,  A61K31/40 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  C07C49/84 ,  C07C69/738 ,  C07C205/45 ,  C07C235/78 ,  C07D207/08 ,  C07D207/12 ,  C07D207/27 ,  C07D211/22 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/50 ,  C07D217/06 ,  C07D239/42 ,  C07D241/08 ,  C07D295/088 ,  C07D295/185 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D317/60 ,  C07D333/22 ,  C07D333/24 ,  C07D409/10

Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.

Abstract translation: 本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基 ，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的 未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上 所述苯甲酰化合物或所述前药的可接受的盐。

公开(公告)号：US07538224B2

公开(公告)日：2009-05-26

申请号：US10561415

申请日：2004-06-10

Applicant: Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

Inventor： Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

IPC: C07D211/22 ,  C07C49/303

CPC classification number: C07D211/42 ,  A61K31/12 ,  A61K31/165 ,  A61K31/216 ,  A61K31/40 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  C07C49/84 ,  C07C69/738 ,  C07C205/45 ,  C07C235/78 ,  C07D207/08 ,  C07D207/12 ,  C07D207/27 ,  C07D211/22 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/50 ,  C07D217/06 ,  C07D239/42 ,  C07D241/08 ,  C07D295/088 ,  C07D295/185 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D317/60 ,  C07D333/22 ,  C07D333/24 ,  C07D409/10

Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.

Abstract translation: 本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基 ，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的 未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上 所述苯甲酰化合物或所述前药的可接受的盐。

公开(公告)号：US20070032532A1

公开(公告)日：2007-02-08

申请号：US10561415

申请日：2004-06-10

Applicant: Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

Inventor： Shinji Nara ,  Hiroshi Nakagawa ,  Yutaka Kanda ,  Takayuki Nakashima ,  Shiro Soga ,  Jiro Kajita ,  Jun-ichi Saito ,  Yukimasa Shiotsu ,  Shiro Akinaga

IPC: A61K31/4192 ,  A61K31/22 ,  A61K31/195 ,  A61K31/165

CPC classification number: C07D211/42 ,  A61K31/12 ,  A61K31/165 ,  A61K31/216 ,  A61K31/40 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  C07C49/84 ,  C07C69/738 ,  C07C205/45 ,  C07C235/78 ,  C07D207/08 ,  C07D207/12 ,  C07D207/27 ,  C07D211/22 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/50 ,  C07D217/06 ,  C07D239/42 ,  C07D241/08 ,  C07D295/088 ,  C07D295/185 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D317/60 ,  C07D333/22 ,  C07D333/24 ,  C07D409/10

Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.

Abstract translation: 本发明提供Hsp90家族蛋白质抑制剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示0〜10的整数，R 1表示取代或未取代的 低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基，取代或未取代的 芳族杂环基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的 低级链烯基等; R 4和R 6和R 6可以相同或不同，分别表示氢原子，卤素，取代或未取代的低级烷基，被取代的 或未取代的芳基等）或其前药，或所述苯甲酰基化合物或所述前药的药学上可接受的盐。