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    MAGNETIC BEAD ACTUATION USING FEEDBACK FOR FTIR BIOSENSOR
    4.
    发明申请
    MAGNETIC BEAD ACTUATION USING FEEDBACK FOR FTIR BIOSENSOR 有权
    使用FTIR生物传感器反馈的磁珠执行

    公开(公告)号：US20100311183A1

    公开(公告)日：2010-12-09

    申请号：US12865864

    申请日：2009-02-02

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01N21/75

    CPC分类号： G01N33/54333 ,  G01N21/552 ,  G01N27/745 ,  G01N33/54373 ,  G01N35/0098

    摘要： The invention provides a method for controlling actuation of label particles in a biosensor device, in particular a biosensor device using frustrated total internal reflection. By applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device, a feedback control of the actuation force is applied. Furthermore, a biosensor device is provided which is adapted for forming the method according to the invention.

    摘要翻译： 本发明提供一种用于控制生物传感器装置中的标签颗粒致动的方法，特别是使用沮丧的全内反射的生物传感器装置。 通过对标签颗粒施加预定的致动力并确定所施加的致动力对生物传感器装置的传感器盒的装订体积或表面的影响，施加致动力的反馈控制。 此外，提供适于形成根据本发明的方法的生物传感器装置。

    EVANESCENT FIELD MODULATION IN A BIOSENSOR
    5.
    发明申请
    EVANESCENT FIELD MODULATION IN A BIOSENSOR 有权
    生物传感器中的EVANESCENT现场调制

    公开(公告)号：US20100290052A1

    公开(公告)日：2010-11-18

    申请号：US12810867

    申请日：2008-12-18

    申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Henricus Maria Kahlman

    发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01N21/55

    CPC分类号： G01N21/552

    摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.

    摘要翻译： 本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。 所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。 该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

    MICROELECTRONIC SENSOR DEVICE WITH MAGNETIC FIELD GENERATOR AND CARRIER
    6.
    发明申请
    MICROELECTRONIC SENSOR DEVICE WITH MAGNETIC FIELD GENERATOR AND CARRIER 审中-公开
    具有磁场发生器和载体的微电子传感器装置

    公开(公告)号：US20100188076A1

    公开(公告)日：2010-07-29

    申请号：US12667396

    申请日：2007-10-23

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Veen

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Veen

    IPC分类号： G01N27/72

    CPC分类号： G01R33/1269 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2400/043 ,  G01N21/552 ,  G01N27/745

    摘要： The invention relates to a microelectronic sensor device for manipulating a sample in an exchangeable carrier (111), for example for optically detecting target particles (1) in a sample liquid that is provided in a sample chamber (2) of the carrier (111). The microelectronic sensor device comprises a number of n>1 magnetic field generators (141-143), e.g. electromagnetic coils, with which magnetic fields can be generated in a target region (110). A control unit (150) is provided that can determine and evaluate the mutual coupling or the self-inductance of the magnetic field generators and/or signals from magnetic field sensors attached to the carrier with respect to the presence and/or state of a carrier (111) in the target region (110). In this way, the control unit (150) can for example detect if the carrier (111) is correctly positioned in the sensor device and/or where a magnetically interactive substance (1, 120) is located.

    摘要翻译： 本发明涉及一种用于操纵可交换载体（111）中的样品的微电子传感器装置，例如用于光学检测设置在载体（111）的样品室（2）中的样品液体中的目标颗粒（1） 。 微电子传感器装置包括多个n≥1个磁场发生器（141-143），例如， 电磁线圈，可以在目标区域（110）中产生磁场。 提供控制单元（150），其可以相对于载体的存在和/或状态来确定和评估附接到载体的磁场传感器的磁场发生器和/或信号的相互耦合或自感 （111）在目标区域（110）中。 以这种方式，控制单元（150）可以例如检测载体（111）是否被正确地定位在传感器装置中和/或磁性交互物质（1,120）所在的位置。

    MAGNETIC SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES
    7.
    发明申请
    MAGNETIC SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES 审中-公开
    用于感应磁性颗粒的磁传感器装置和方法

    公开(公告)号：US20090278534A1

    公开(公告)日：2009-11-12

    申请号：US12305385

    申请日：2007-06-18

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01R33/09

    CPC分类号： G01R33/12 ,  B82Y25/00 ,  G01N15/0656 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/54373 ,  G01R33/09 ,  G01R33/093 ,  G01R33/1269

    摘要： A magnetic sensor device (300) for sensing magnetic particles (15), the magnetic sensor device (300) comprising a magnetic field generator unit (12) adapted for generating a plurality of different magnetic field configurations assigned to a plurality of different magnetic excitation states of the magnetic particles (15), a sensing unit (11) adapted for sensing a plurality of detection signals influenced by the magnetic particles (15) in the different magnetic field configurations, and a combining unit (30) adapted for combining the plurality of signals to thereby derive information indicative of the presence of the magnetic particles (15).

    摘要翻译： 一种用于感测磁性颗粒（15）的磁性传感器装置（300），该磁性传感器装置（300）包括一个适于产生分配给多个不同磁激励状态的多个不同磁场配置的磁场发生器单元（12） 的磁性颗粒（15）的感测单元（11），适用于感测由不同磁场结构中的磁性颗粒（15）影响的多个检测信号的感测单元（11），以及组合单元（30） 信号，从而导出指示磁性颗粒（15）的存在的信息。

    METHOD AND DEVICE FOR CHARACTERIZATION OF A MAGNETIC FIELD APPLIED TO A MAGNETIC SENSOR
    8.
    发明申请
    METHOD AND DEVICE FOR CHARACTERIZATION OF A MAGNETIC FIELD APPLIED TO A MAGNETIC SENSOR 审中-公开
    用于磁性传感器的磁场特性的方法和装置

    公开(公告)号：US20090243594A1

    公开(公告)日：2009-10-01

    申请号：US11721573

    申请日：2005-12-20

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01R33/09 ,  G01R35/00 ,  G01R33/02

    CPC分类号： G01R33/093 ,  B82Y25/00 ,  G01N27/745 ,  G01N35/0098 ,  G01R33/09 ,  G01R33/12 ,  G01R33/1269

    摘要： The present invention provides a magnetic sensor device comprising a plurality of magnetic sensor elements having a sensitive direction. At least one of the magnetic sensor elements (43) is provided with a flux-guide (44) for concentrating onto the sensor element in its sensitive direction a magnetic field applied to the magnetic sensor device. The applied magnetic field is thus bent into the sensitive direction of the magnetic sensor element by the flux-guide. In that way, the field strength and/or orientation of the applied magnetic field can be measured in the absence of magnetic particles. This may be used for, for example, calibration of magnetic sensor devices.

    摘要翻译： 本发明提供一种包括具有敏感方向的多个磁传感器元件的磁传感器装置。 磁传感器元件（43）中的至少一个设置有磁通（44），用于在其敏感方向上将传感器元件集中在施加到磁传感器装置的磁场上。 所施加的磁场因此通过磁通引导件弯曲成磁传感器元件的敏感方向。 以这种方式，可以在没有磁性颗粒的情况下测量施加的磁场的场强和/或取向。 这可以用于例如磁传感器装置的校准。

    SENSOR DEVICE WITH ADAPTIVE FIELD COMPENSATION
    10.
    发明申请
    SENSOR DEVICE WITH ADAPTIVE FIELD COMPENSATION 审中-公开
    具有自适应场补偿的传感器装置

    公开(公告)号：US20090184706A1

    公开(公告)日：2009-07-23

    申请号：US12302046

    申请日：2007-05-11

    申请人： Haris Duric ,  Josephus Arnoldus Henricus Maria Kahlman

    发明人： Haris Duric ,  Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01N27/72 ,  G01R35/00

    CPC分类号： G01R33/093 ,  B82Y25/00 ,  G01N27/745 ,  G01N33/54326 ,  G01R33/12 ,  G01R33/1269

    摘要： The invention relates to a magnetic sensor device comprising an excitation wire for the generation of an alternating magnetic excitation field (Bi) and a GMR sensor (12) for sensing reaction fields (B2) generated by magnetized particles (2) in reaction to the excitation fields. Moreover, it comprises a compensator (15) for the generation of a magnetic compensation field (B3) that adaptively cancels predetermined spectral components of all magnetic fields (B2, B3) which lie in the sensitive direction of the magnetic sensor element (12). Measurements of the GMR sensor (12) are thus made robust against gain variations of the sensor.

    摘要翻译： 本发明涉及一种磁传感器装置，包括用于产生交变磁场（Bi）的激励线和用于感测由激磁颗粒（2）产生的反应场（B2）的GMR传感器（12） 领域。 此外，它包括用于产生磁补偿场（B3）的补偿器（15），其自动地消除位于磁传感器元件（12）的敏感方向上的所有磁场（B2，B3）的预定频谱分量。 因此，GMR传感器（12）的测量对于传感器的增益变化是鲁棒的。