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公开(公告)号：US4753879A
公开(公告)日：1988-06-28
申请号：US644537
申请日：1984-08-27
申请人： Joseph J. Rosa , Margaret D. Rosa
发明人： Joseph J. Rosa , Margaret D. Rosa
CPC分类号： C12N9/6459 , C12Y304/21069 , A61K38/00
摘要： Modified human tissue plasminogen activators, the DNA sequences coding on expression for them and methods of making them in hosts transformed with those DNA sequences. The single chain form of these modified human t-PAs, t-PA (Lys 277.fwdarw.X), has a longer half life than the single chain form of native, or recombinant, t-PA, yet, in the two chain form these modified t-PAs have substantially the same affinity for fibrin and substantially the same activity as the two chain form of native, or recombinant, t-PA.
摘要翻译： 修饰的人组织纤溶酶原激活剂，编码它们的表达的DNA序列和在用这些DNA序列转化的宿主中制备它们的方法。 这些修饰的人t-PA（t-PA（Lys 277-> X））的单链形式比单链形式的天然或重组t-PA具有更长的半衰期，但是在两链形式 这些修饰的t-PA对纤维蛋白具有基本上相同的亲和力，并且与两种链形式的天然或重组t-PA具有基本上相同的活性。
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2.发明授权Anti-CD4 antibody homologs useful in prophylaxis and treatment of AIDS, ARC and HIV infection 失效抗CD4抗体同系物可用于预防和治疗AIDS，ARC和HIV感染
公开(公告)号：US5871732A
公开(公告)日：1999-02-16
申请号：US916098
申请日：1991-11-27
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P31/00 , A61P31/12 , A61P31/18 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N5/10 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/569 , C08G75/14
CPC分类号： C07K16/2812 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： Anti-CD4 antibody homologs, DNA sequences and recombinant DNA molecules encoding them, prophylactic, immunotherapeutic and diagnostic compositions comprising those antibody homologs, and methods for preventing or treating diseases in mammals, including humans, caused by infective agents whose primary targets are CD4.sup.+ lymphocytes. Such diseases include acquired immune deficiency syndrome ("AIDS"), AIDS related complex, and human immunodeficiency virus infection.
摘要翻译： 包含抗体同系物的抗CD4抗体同系物，DNA序列和编码它们的重组DNA分子，预防性，免疫治疗和诊断组合物，以及预防或治疗哺乳动物（包括人）由主要靶标为CD4 +淋巴细胞的感染因子引起的疾病的方法。 这些疾病包括获得性免疫缺陷综合征（“AIDS”），AIDS相关复合物和人类免疫缺陷病毒感染。
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