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    MODEL MEMBRANE SYSTEMS
    5.
    发明申请
    MODEL MEMBRANE SYSTEMS 审中-公开
    模型膜系统

    公开(公告)号：US20080038281A1

    公开(公告)日：2008-02-14

    申请号：US11688621

    申请日：2007-03-20

    Applicant: Joseph Altin ,  Christopher Parish

    Inventor： Joseph Altin ,  Christopher Parish

    IPC: A61K39/00 ,  A61P43/00

    CPC classification number: A61K38/1866 ,  A61K9/1271 ,  A61K39/0011 ,  A61K47/6911 ,  A61K2039/5152 ,  A61K2039/55555 ,  C12N11/02 ,  G01N33/5432 ,  G01N33/54353 ,  G01N33/92

    Abstract: The present invention relates generally to modifying biological and/or synthetic membranes or liposomes, or combinations thereof, for the purpose of altering immunity, or for the targeting of drugs and other agents to a specific cell type or tissue when administered in vivo to achieve a therapeutic effect. Modification of the membranes is achieved by incorporation and/or attachment of metal chelating groups, thereby allowing engraftment of one or more targeting molecules possessing a metal affinity tag, and a targeting of the engrafted membranes to specific cell types or tissues in vivo. The invention, thus, provides a means of modifying the properties of biological and/or synthetic membranes and liposomes for the purpose of altering or enhancing immunity when used as vaccines, or for the targeting of encapsulated/incorporated drugs or other agents to a specific cell type or tissue when administered in vivo, to achieve a therapeutic effect or response, or for modifying a physiological response or biological function.

    Abstract translation: 本发明一般涉及改变生物和/或合成的膜或脂质体或其组合，以改变免疫力，或者当在体内施用时将药物和其它试剂靶向特定的细胞类型或组织以实现 治疗效果。 通过掺入和/或附着金属螯合基团来实现膜的修饰，从而允许植入具有金属亲和标签的一种或多种靶向分子，并将植入的膜靶向体内特定的细胞类型或组织。 因此，本发明提供了当用作疫苗时改变生物和/或合成膜和脂质体的性质以改变或增强免疫的目的，或将包封/掺入的药物或其它试剂靶向特定细胞的方法 类型或组织，以实现治疗效果或反应，或用于改变生理反应或生物学功能。

    MODEL MEMBRANE SYSTEMS
    6.
    发明申请
    MODEL MEMBRANE SYSTEMS 审中-公开
    模型膜系统

    公开(公告)号：US20100143456A1

    公开(公告)日：2010-06-10

    申请号：US12638373

    申请日：2009-12-15

    Applicant: Joseph Altin ,  Christopher Richard Parish

    Inventor： Joseph Altin ,  Christopher Richard Parish

    IPC: A61K9/127 ,  A61K35/00 ,  A61K39/00 ,  A61K35/12 ,  A61P43/00

    CPC classification number: A61K38/1866 ,  A61K9/1271 ,  A61K39/0011 ,  A61K47/6911 ,  A61K2039/5152 ,  A61K2039/55555 ,  C12N11/02 ,  G01N33/5432 ,  G01N33/54353 ,  G01N33/92

    Abstract: The present invention relates generally to modifying biological and/or synthetic membranes or liposomes, or combinations thereof, for the purpose of altering immunity, or for the targeting of drugs and other agents to a specific cell type or tissue when administered in vivo to achieve a therapeutic effect. Modification of the membranes is achieved by incorporation and/or attachment of metal chelating groups, thereby allowing engraftment of one or more targeting molecules possessing a metal affinity tag, and a targeting of the engrafted membranes to specific cell types or tissues in vivo. The invention, thus, provides a means of modifying the properties of biological and/or synthetic membranes and liposomes for the purpose of altering or enhancing immunity when used as vaccines, or for the targeting of encapsulated/incorporated drugs or other agents to a specific cell type or tissue when administered in vivo, to achieve a therapeutic effect or response, or for modifying a physiological response or biological function.

    Abstract translation: 本发明一般涉及改变生物和/或合成的膜或脂质体或其组合，以改变免疫力，或者当在体内施用时将药物和其它试剂靶向特定的细胞类型或组织以实现 治疗效果。 通过掺入和/或附着金属螯合基团来实现膜的修饰，从而允许植入具有金属亲和标签的一种或多种靶向分子，并将植入的膜靶向体内特定的细胞类型或组织。 因此，本发明提供了当用作疫苗时改变生物和/或合成膜和脂质体的性质以改变或增强免疫的目的，或将包封/掺入的药物或其它试剂靶向特定细胞的方法 类型或组织，以实现治疗效果或反应，或用于改变生理反应或生物学功能。

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