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    Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques
    1.
    发明授权
    Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques 有权
    具有多个样品管并使用浊度光散射技术的样品充分度测量系统

    公开(公告)号：US08355132B2

    公开(公告)日：2013-01-15

    申请号：US12617491

    申请日：2009-11-12

    申请人： Jiulin Xia ,  Richard L. Mantefuel ,  Carl Theodore Edens ,  Jonathan Matthew Miller ,  Nadia P. Allen

    发明人： Jiulin Xia ,  Richard L. Mantefuel ,  Carl Theodore Edens ,  Jonathan Matthew Miller ,  Nadia P. Allen

    IPC分类号： G01N21/03 ,  G01N21/51

    CPC分类号： B01L9/06 ,  B01L9/50 ,  G01N35/0099

    摘要： A sample adequacy measurement system having sample tubes and a housing having a receptacle to receive the sample tubes. The housing has sample adequacy measurement stations that each have a light source and a sample detector. The light source generates an illumination beam directed into one of the sample tubes. The sample detector is positioned along the tube, and receives at least a portion of the illumination beam scattered by turbidity in the sample tube. The detector is positioned at the end of an emitted beam path that extends in a plane that is perpendicular to the vertical direction and is oriented at a non-perpendicular angle with respect to the longitudinal axis of the sample tube unit. This reduce the likelihood that the emitted beam will pass through a damaged portion of the respective one of the sample tubes by passing the light through a protected portion of the tube.

    摘要翻译： 具有样品管的样品充分度测量系统和具有用于接收样品管的容器的壳体。 壳体具有各自具有光源和样品检测器的样本适当性测量站。 光源产生引导到一个样品管中的照明光束。 样品检测器沿着管定位，并且接收由样品管中的浊度散射的照射束的至少一部分。 检测器位于发射的光束路径的端部，其在垂直于垂直方向的平面中延伸并且相对于样品管单元的纵向轴线以非垂直的角度定向。 这降低了发射的光束通过使光穿过管的受保护部分而穿过相应的一个样品管的损坏部分的可能性。

    Reagent cabinet system
    3.
    发明授权
    Reagent cabinet system 有权
    试剂柜系统

    公开(公告)号：US08282895B2

    公开(公告)日：2012-10-09

    申请号：US12831046

    申请日：2010-07-06

    申请人： Jonathan Matthew Miller ,  Yancy Kenan Ragin

    发明人： Jonathan Matthew Miller ,  Yancy Kenan Ragin

    IPC分类号： B01L1/00

    CPC分类号： G01N35/1002 ,  G01N35/028 ,  G01N35/1067 ,  Y02P20/582 ,  Y10T137/474 ,  Y10T137/4807 ,  Y10T137/7032

    摘要： A reagent cabinet for an automated processing apparatus. The reagent cabinet has a housing, and a drawer slidably mounted in the housing. The drawer has a lower deck adapted to receive a fluid reservoir, and an upper deck located above the lower deck and adapted to receive a fluid supply container. A supply connection hose is provided to selectively connect the fluid supply container to the fluid reservoir. A reservoir connection hose is provided to selectively connect to the fluid reservoir and to convey fluid from the fluid reservoir to a downstream location outside the cabinet. A pump is mounted on the drawer. The pump is adapted to convey fluid through either the supply connection hose or the reservoir connection hose.

    摘要翻译： 一种用于自动化处理设备的试剂柜。 试剂柜具有壳体和可滑动地安装在壳体中的抽屉。 抽屉具有适于容纳流体储存器的下甲板和位于下甲板上方并适于接收流体供应容器的上甲板。 供应连接软管被提供以选择性地将流体供应容器连接到流体储存器。 提供储液器连接软管以选择性地连接到流体储存器并将流体从流体储存器输送到机柜外部的下游位置。 一个泵安装在抽屉上。 泵适于通过供应连接软管或储存器连接软管输送流体。

    Ensuring Sample Adequacy Using Turbidity Light Scattering Techniques
    4.
    发明申请
    Ensuring Sample Adequacy Using Turbidity Light Scattering Techniques 有权
    使用浊度光散射技术确保样本充足性

    公开(公告)号：US20100225920A1

    公开(公告)日：2010-09-09

    申请号：US12617491

    申请日：2009-11-12

    申请人： Jiulin Xia ,  Richard L. Mantefuel ,  Carl Theodore Edens ,  Jonathan Matthew Miller ,  Nadia P. Allen

    发明人： Jiulin Xia ,  Richard L. Mantefuel ,  Carl Theodore Edens ,  Jonathan Matthew Miller ,  Nadia P. Allen

    IPC分类号： G01N21/01

    CPC分类号： B01L9/06 ,  B01L9/50 ,  G01N35/0099

    摘要： Cervical cancer screening using HPV testing can yields a high negative predictive value of approximately 99.5% for prediction of cervical lesions of CIN3 or greater. However, sample adequacy can affect the number of at-risk women that may go undetected due to the inadequacy of the tested sample. We have approached this challenge of increasing sample assurance of the negative results by estimating the cell count in known fluid volumes using light scattering techniques, in particular turbidity. These methods may be used as a fast, convenient, and economical method for measuring sample adequacy for other uses as well. Particular examples using these methods in conjunction with the HC2 HPV test are provided herein.

    摘要翻译： 使用HPV检测宫颈癌筛查可以产生大约99.5％的高阴性预测值，用于预测CIN3或更高的宫颈病变。 然而，由于测试样本不足，样本充足性可能会影响可能未检测到的高危女性的数量。 我们已经通过使用光散射技术（特别是浊度）估计已知流体体积中的细胞计数来增加负面结果的样本保证。 这些方法可以用作测量样品对其他用途的充分性的快速，方便和经济的方法。 本文提供了与HC2 HPV检测结合使用这些方法的具体实例。

    Reagent Cabinet System
    5.
    发明申请
    Reagent Cabinet System 有权
    试剂柜系统

    公开(公告)号：US20110158865A1

    公开(公告)日：2011-06-30

    申请号：US12831046

    申请日：2010-07-06

    申请人： Jonathan Matthew Miller ,  Yancy Kenan Ragin

    发明人： Jonathan Matthew Miller ,  Yancy Kenan Ragin

    IPC分类号： B01L99/00 ,  B65B3/04

    CPC分类号： G01N35/1002 ,  G01N35/028 ,  G01N35/1067 ,  Y02P20/582 ,  Y10T137/474 ,  Y10T137/4807 ,  Y10T137/7032

    摘要： A reagent cabinet for an automated processing apparatus. The reagent cabinet has a housing, and a drawer slidably mounted in the housing. The drawer has a lower deck adapted to receive a fluid reservoir, and an upper deck located above the lower deck and adapted to receive a fluid supply container. A supply connection hose is provided to selectively connect the fluid supply container to the fluid reservoir. A reservoir connection hose is provided to selectively connect to the fluid reservoir and to convey fluid from the fluid reservoir to a downstream location outside the cabinet. A pump is mounted on the drawer. The pump is adapted to convey fluid through either the supply connection hose or the reservoir connection hose.

    摘要翻译： 一种用于自动化处理设备的试剂柜。 试剂柜具有壳体和可滑动地安装在壳体中的抽屉。 抽屉具有适于容纳流体储存器的下甲板和位于下甲板上方并适于接收流体供应容器的上甲板。 供应连接软管被提供以选择性地将流体供应容器连接到流体储存器。 提供储液器连接软管以选择性地连接到流体储存器并将流体从流体储存器输送到机柜外部的下游位置。 一个泵安装在抽屉上。 泵适于通过供应连接软管或储存器连接软管输送流体。

    Open platform hybrid manual-automated sample processing system
    6.
    发明授权
    Open platform hybrid manual-automated sample processing system 有权
    开放平台混合手动自动样品处理系统

    公开(公告)号：US08703492B2

    公开(公告)日：2014-04-22

    申请号：US12588306

    申请日：2009-10-09

    申请人： Brian Austin Self ,  Jonathan Matthew Miller ,  Carl Theodore Edens

    发明人： Brian Austin Self ,  Jonathan Matthew Miller ,  Carl Theodore Edens

    IPC分类号： G01N35/02 ,  G01N1/18 ,  G01N1/10 ,  G01N21/31

    CPC分类号： G01N35/026 ,  G01N35/04 ,  G01N2035/00524 ,  G01N2035/0405 ,  G01N2035/041 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

    摘要： An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container. The system also includes a sample output adapted to receive the output vessel, and a user interface adapted to receive an input from the user to indicate the identity of the at least one sample container, and control at least one operation based on a physical property of the at least one sample container.

    摘要翻译： 一种自动样品处理系统，其具有适于同时接收多个样品容器的样品输入，适于接收一种或多种新试剂供应的试剂输入，适于接收一种或多种新的消耗品的消耗品输入，适于 接收废旧消耗品，适于接收一种或多种使用过的试剂供应的废液输出，以及处理中心。 加工中心包括一个适于从至少一个样品容器中取出盖子的去皮器，适于从至少一个样品容器中移出试样并将样品转移到输出容器上的抽吸器，以及适于将盖子更换 所述至少一个样品容器。 该系统还包括适于接收输出容器的采样输出端和适于接收来自用户的输入以指示至少一个采样容器的标识的用户界面，并且基于物理属性来控制至少一个操作 所述至少一个样品容器。

    Open platform automated sample processing system
    9.
    发明申请
    Open platform automated sample processing system 有权
    开放平台自动化样品处理系统

    公开(公告)号：US20100126286A1

    公开(公告)日：2010-05-27

    申请号：US12588306

    申请日：2009-10-09

    申请人： Brian Austin Self ,  Jonathan Matthew Miller ,  Carl Theodore Edens

    发明人： Brian Austin Self ,  Jonathan Matthew Miller ,  Carl Theodore Edens

    IPC分类号： G01N1/18 ,  B01L3/02

    CPC分类号： G01N35/026 ,  G01N35/04 ,  G01N2035/00524 ,  G01N2035/0405 ,  G01N2035/041 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

    摘要： An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container. The system also includes a sample output adapted to receive the output vessel, and a user interface adapted to receive an input from the user to indicate the identity of the at least one sample container, and control at least one operation based on a physical property of the at least one sample container.

    摘要翻译： 一种自动样品处理系统，其具有适于同时接收多个样品容器的样品输入，适于接收一种或多种新试剂供应的试剂输入，适于接收一种或多种新的消耗品的消耗品输入，适于 接收废旧消耗品，适于接收一种或多种使用过的试剂供应的废液输出，以及处理中心。 加工中心包括一个适于从至少一个样品容器中取出盖子的去皮器，适于从至少一个样品容器中移出试样并将样品转移到输出容器上的抽吸器，以及适于将盖子更换 所述至少一个样品容器。 该系统还包括适于接收输出容器的采样输出端和适于接收来自用户的输入以指示至少一个采样容器的标识的用户界面，并且基于物理属性来控制至少一个操作 所述至少一个样品容器。