公开(公告)号：US5206370A

公开(公告)日：1993-04-27

申请号：US888282

申请日：1992-05-26

Applicant: David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giadomenico ,  Jon A. Zubieta

Inventor： David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giadomenico ,  Jon A. Zubieta

IPC: A61K47/48 ,  C07D207/40 ,  C07D207/404 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534

CPC classification number: C07D207/404 ,  A61K47/48169 ,  A61K47/48384 ,  A61K47/48715 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534 ,  Y10S436/804

Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.

Abstract translation: 能够将金属离子连接到生物有用分子的双功能芳族化合物。 双官能化合物的特征在于具有肼或酰肼基团和蛋白质反应性基团。 肼或酰肼基团可以被保护为低级烷基腙。 还描述了双官能化合物与大分子的缀合物，并且提供了由缀合物和金属离子组成的标记的大分子。 另外，提供了通过使结合物与金属物质反应形成标记的大分子的方法本发明的化合物和方法在用于成像和/或治疗的生物学和医学领域中特别有用。

公开(公告)号：US06217845B1

公开(公告)日：2001-04-17

申请号：US08965188

申请日：1997-11-06

Applicant: David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giandomenico ,  Jon A. Zubieta

Inventor： David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giandomenico ,  Jon A. Zubieta

IPC: A61K5100

CPC classification number: C07D207/404 ,  A61K47/56 ,  A61K47/6803 ,  A61K47/6889 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534 ,  Y10S436/804

Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.

Abstract translation: 能够将金属离子连接到生物有用分子的双功能芳族化合物。 双官能化合物的特征在于具有肼或酰肼基团和蛋白质反应性基团。 肼或酰肼基团可以被保护为低级烷基腙。 还描述了双官能化合物与大分子的缀合物，并且提供了由缀合物和金属离子组成的标记的大分子。 此外，提供了通过使轭合物与金属物质反应形成标记的大分子的方法。 本发明的化合物和方法在用于成像和/或治疗的生物学和医学领域中特别有用。

公开(公告)号：US5753520A

公开(公告)日：1998-05-19

申请号：US384641

申请日：1995-02-06

Applicant: David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giandomenico ,  Jon A. Zubieta

Inventor： David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giandomenico ,  Jon A. Zubieta

IPC: A61K47/48 ,  C07D207/40 ,  C07D207/404 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534 ,  C07K16/00 ,  C07K17/00

CPC classification number: C07D207/404 ,  A61K47/48169 ,  A61K47/48384 ,  A61K47/48715 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534 ,  Y10S436/804

Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.

Abstract translation: 能够将金属离子连接到生物有用分子的双功能芳族化合物。 双官能化合物的特征在于具有肼或酰肼基团和蛋白质反应性基团。 肼或酰肼基团可以被保护为低级烷基腙。 还描述了双官能化合物与大分子的缀合物，并且提供了由缀合物和金属离子组成的标记的大分子。 此外，提供了通过使轭合物与金属物质反应形成标记的大分子的方法。 本发明的化合物和方法在用于成像和/或治疗的生物学和医学领域中特别有用。

公开(公告)号：US5420285A

公开(公告)日：1995-05-30

申请号：US26426

申请日：1993-03-04

Applicant: David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giandomenico ,  Jon A. Zubieta

Inventor： David A. Schwartz ,  Michael J. Abrams ,  Christen M. Giandomenico ,  Jon A. Zubieta

IPC: A61K47/48 ,  C07D207/40 ,  C07D207/404 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534 ,  C07D401/02 ,  C07D403/02 ,  C07D403/12

CPC classification number: C07D207/404 ,  A61K47/48169 ,  A61K47/48384 ,  A61K47/48715 ,  C07D207/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  G01N33/534 ,  Y10S436/804

Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.

Abstract translation: 能够将金属离子连接到生物有用分子的双功能芳族化合物。 双官能化合物的特征在于具有肼或酰肼基团和蛋白质反应性基团。 肼或酰肼基团可以被保护为低级烷基腙。 还描述了双官能化合物与大分子的缀合物，并且提供了由缀合物和金属离子组成的标记的大分子。 此外，提供了通过使轭合物与金属物质反应形成标记的大分子的方法。 本发明的化合物和方法在用于成像和/或治疗的生物学和医学领域中特别有用。

公开(公告)号：US5602266A

公开(公告)日：1997-02-11

申请号：US564760

申请日：1995-11-29

Applicant: Robert C. Haushalter ,  Mohammad I. Khan ,  Linda M. Meyer ,  Jon A. Zubieta

Inventor： Robert C. Haushalter ,  Mohammad I. Khan ,  Linda M. Meyer ,  Jon A. Zubieta

IPC: C07F9/00 ,  C07F9/02

CPC classification number: C07F9/005

Abstract: A new class of vanadium phosphate materials using a mixed valence pentavanadate as the building block has been created using hydrothermal self-assembly techniques. These materials use a framework composed solely of V.sub.5 O.sub.9 (PO.sub.4).sub.4/2 pentamers and apart from the cationic template contain some of the largest voids and cavities yet reported in open framework solids.

Abstract translation: 使用水热自组装技术制造了使用混合价五价钒酸盐作为结构单元的新一类磷酸钒材料。 这些材料使用仅由V5O9（PO4）4/2五聚体组成的框架，并且除了阳离子模板之外，还包含一些最大的空隙和空腔，而在开放框架固体中报道。

公开(公告)号：US5324848A

公开(公告)日：1994-06-28

申请号：US29444

申请日：1993-03-11

Applicant: Robert C. Haushalter ,  Victoria G. Soghomonian ,  Jon A. Zubieta

Inventor： Robert C. Haushalter ,  Victoria G. Soghomonian ,  Jon A. Zubieta

IPC: C01G31/00 ,  C01B25/37 ,  C07F9/00 ,  C07F9/09 ,  C07F9/38 ,  C07F9/02

CPC classification number: C07F9/005 ,  C07F9/3808

Abstract: A new class of vanadium phosphate materials has been created using hydrothermanl self-assembly techniques. Of particular interest is that these materials comprise a vanadium phosphate framework structure about an organic template that after removal leave a microporous structure. These materials typically are produced by a reaction in an aqueous solution that includes one or more phosphate sources, one or more vanadium or vanadium oxide sources, an alkali metal or alkali-earth metal sources, and an organic amine or diamine templating agent.

Abstract translation: 使用hydrothermanl自组装技术制造了一类新的磷酸钒材料。 特别令人感兴趣的是，这些材料包含关于去除后留下微孔结构的有机模板的磷酸钒框架结构。 这些材料通常通过在包括一种或多种磷酸盐源，一种或多种钒或氧化钒源，碱金属或碱土金属源和有机胺或二胺模板剂的水溶液中的反应来制备。