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公开(公告)号：US06743445B2
公开(公告)日：2004-06-01
申请号：US10137702
申请日：2002-05-03
IPC分类号： A61K936
CPC分类号： A61K9/286 , A61K9/5036 , A61K9/5047 , Y10S514/964
摘要： A method of coating an active material is provided. The method comprises contacting an active material with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser at a temperature of less than 60° C. The method finds particular application in the preparation of dosage forms comprising active materials that are unstable at temperatures in excess of 60° C. The compositions prepared in accordance with the method can be used to deliver an active material to the colon.
摘要翻译： 提供涂覆活性物质的方法。 该方法包括在低于60℃的温度下使活性材料与包含直链淀粉 - 醇络合物的水性分散体，不溶性成膜聚合物和增塑剂的成膜组合物接触。该方法特别适用于 制备包含在超过60℃的温度下不稳定的活性物质的剂型。可以使用根据该方法制备的组合物将活性物质递送至结肠。
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公开(公告)号：US06387964B1
公开(公告)日：2002-05-14
申请号：US09810468
申请日：2001-03-19
IPC分类号： C08J520
CPC分类号： B01D67/0093 , B01D2323/30 , B01D2323/34 , B01D2323/38 , C08F255/02 , C08F259/02 , C08F259/08 , C08F291/18
摘要： A monomer-grafted cross-linked polymer is prepared by the steps of activating a polymer by radiation, quenching the activated polymer so as to effect cross-linking therein, activating the cross-linked polymer by irradiation and contacting the activated cross-linked polymer with an emulsion that includes an unsaturated monomer, an emulsifier and water. The activated cross-linked polymer is contacted with the emulsion for a sufficient time to effect a desired extent of grafting.
摘要翻译： 通过以下步骤制备单体接枝的交联聚合物：通过辐射活化聚合物，淬灭活化的聚合物以便在其中进行交联，通过照射活化交联的聚合物并使活化的交联聚合物与 包括不饱和单体，乳化剂和水的乳液。 活化的交联聚合物与乳液接触足够的时间以实现所需的接枝程度。
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公开(公告)号：US06225368B1
公开(公告)日：2001-05-01
申请号：US09391251
申请日：1999-09-07
IPC分类号： C08J328
CPC分类号： B01D67/0093 , B01D2323/30 , B01D2323/34 , B01D2323/38 , C08F255/02 , C08F259/02 , C08F259/08 , C08F291/18
摘要： A monomer-grafted cross-linked polymer is prepared by the steps of activating a polymer by radiation, quenching the activated polymer so as to effect cross-linking therein, activating the cross-linked polymer by irradiation and contacting the activated cross-linked polymer with an emulsion that includes an unsaturated monomer, an emulsifier and water. The activated cross-linked polymer is contacted with the emulsion for a sufficient time to effect a desired extent of grafting.
摘要翻译： 通过以下步骤制备单体接枝的交联聚合物：通过辐射活化聚合物，淬灭活化的聚合物以便在其中进行交联，通过照射活化交联的聚合物并使活化的交联聚合物与 包括不饱和单体，乳化剂和水的乳液。 活化的交联聚合物与乳液接触足够的时间以实现所需的接枝程度。
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4.发明授权Method for the preparation of cation exchange membranes doped with insoluble metal salts 失效制备掺有不溶性金属盐的阳离子交换膜的方法
公开(公告)号：US5705534A
公开(公告)日：1998-01-06
申请号：US657953
申请日：1996-06-04
CPC分类号： C08J5/225 , H01M2/16 , H01M8/0289 , C08J2327/12 , H01M8/188 , Y02E60/528
摘要： A method of preparing a modified cation exchange membrane in which a sulfide of silver, tungsten, molybdenum or a mixture thereof is deposited within the polymer matrix, which method comprises the steps of: i) forming within the polymer matrix of the membrane a complex of silver, tungsten, molybdenum or a mixture thereof with a water soluble compound containing an --SH group; and ii) converting the complex formed in step (i) into the insoluble sulfide of silver, tungsten, molybdenum or a mixture thereof.
摘要翻译： 一种制备改性阳离子交换膜的方法，其中银，钨，钼或其混合物的硫化物沉积在聚合物基质内，该方法包括以下步骤：i）在膜的聚合物基质内形成复合物 银，钨，钼或其与含-SH基团的水溶性化合物的混合物; 和ii）将步骤（i）中形成的络合物转化为银，钨，钼或其混合物的不溶性硫化物。
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5.发明授权公开(公告)号：US06630150B1
公开(公告)日：2003-10-07
申请号：US09889196
申请日：2001-10-15
IPC分类号： A61K9107
CPC分类号： A61K9/1617 , A61K9/1623 , A61K9/1652
摘要： A self-emulsifying system comprises i) microcrystalline cellulose and ii) an oily substance, surfactant, and water is useful for providing solid dosage forms of hydrophobic or water sensitive agents when dried or extruded and spheronized.
摘要翻译： 自乳化系统包括i）微晶纤维素和ii）油性物质，表面活性剂和水可用于在干燥或挤出和滚圆时提供疏水性或水敏感剂的固体剂型。
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公开(公告)号：US06534549B1
公开(公告)日：2003-03-18
申请号：US09516253
申请日：2000-03-01
申请人： John Michael Newton , Lee Fung Siew
发明人： John Michael Newton , Lee Fung Siew
IPC分类号： A61K4732
CPC分类号： A61K9/5047 , A61K9/5036
摘要： A method for producing a controlled release composition is provided. A solution of a film-forming composition comprising a mixture of a substantially water-insoluble film-forming polymer and amylose in a solvent system comprising (1) water and (2) a water-miscible organic solvent which on its own is capable of dissolving the film-forming polymer is contacted with an active material and the resulting composition dried. The weight ratio of amylose to film-forming insoluble polymer in the film-forming composition is in the range 1:2 to 3:2 and the organic solvent comprises at least 50% by weight of the solvent system. The composition is particularly suitable for delivering therapeutic agents to the colon.
摘要翻译： 提供了一种制备控释组合物的方法。 一种成膜组合物，其包含基本上不溶于水的成膜聚合物和直链淀粉的混合物在溶剂体系中的溶液，其包含（1）水和（2）能够溶解的水混溶性有机溶剂 使成膜聚合物与活性材料接触，并将所得组合物干燥。 成膜组合物中直链淀粉与成膜不溶性聚合物的重量比在1:2至3:2的范围内，有机溶剂占溶剂体系的至少50重量％。 该组合物特别适用于将治疗剂递送至结肠。
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公开(公告)号：US5683719A
公开(公告)日：1997-11-04
申请号：US444054
申请日：1995-05-18
申请人： John Michael Newton
发明人： John Michael Newton
CPC分类号： A61K9/0092
摘要： A controlled release composition comprising an extruded core of active material and excipients, said core being coated in a water insoluble coating. Preferably the core comprises a pharmaceutically acceptable active ingredient together with microcrystalline cellulose, a clay such as kaolin and a binder such as poly(vinyl-pyrrolidine).
摘要翻译： 一种控释组合物，其包含活性物质的挤出核心和赋形剂，所述核心涂覆在水不溶性涂层中。 优选地，核心包含药学上可接受的活性成分以及微晶纤维素，粘土如高岭土和粘合剂如聚（乙烯基 - 吡咯烷）。
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