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1.发明申请RECOMBINANT ANTIBODIES FOR TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS 审中-公开治疗呼吸道感染病毒感染的重组抗体公开(公告)号：US20110189171A1
公开(公告)日：2011-08-04
申请号：US12974585
申请日：2010-12-21
Applicant: Johan Lantto , Henriette Schjonning Nielsen
Inventor： Johan Lantto , Henriette Schjonning Nielsen
CPC classification number: C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N2760/18511
Abstract: Disclosed are novel polyclonal antibodies, which target respiratory syncytial virus (RSV), as well as novel high affinity antibody molecules reactive with RSV. The polyclonal antibodies may comprise antibody molecules which are reactive with both RSV protein F and RSV protein G, and preferably the polyclonal antibodies target a variety of epitopes on these proteins. The antibody molecules of the invention have shown superior efficacy in vitro and/or in vivo. Also disclosed are methods of producing the antibodies of the invention as well as methods of their use in treatment or prevention of RSV infection.
Abstract translation: 公开了靶向呼吸道合胞病毒（RSV）的新型多克隆抗体，以及与RSV反应的新型高亲和力抗体分子。 多克隆抗体可以包含与RSV蛋白F和RSV蛋白G两者都具有反应性的抗体分子，优选多克隆抗体靶向这些蛋白质上的多种表位。 本发明的抗体分子在体外和/或体内显示出优异的功效。 还公开了产生本发明的抗体的方法以及它们在治疗或预防RSV感染中的用途。
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公开(公告)号：US20110158984A1
公开(公告)日：2011-06-30
申请号：US12965437
申请日：2010-12-10
Applicant: Allan Jensen , Johan Lantto , Margit Haahr Hansen , Lone Kjær Rasmussen , Søren Kofoed Rasmussen , Lucilla Steinaa
Inventor： Allan Jensen , Johan Lantto , Margit Haahr Hansen , Lone Kjær Rasmussen , Søren Kofoed Rasmussen , Lucilla Steinaa
CPC classification number: C07K16/081 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92
Abstract: Disclosed is an anti-orthopoxvirus recombinant polyclonal antibody comprising distinct members which in union are capable of binding at least three orthopoxvirus related antigens, a pharmaceutical composition comprising the antibody, and a method for its production. Also disclosed is a polyclonal cell line capable of producing the recombinant polyclonal antibody as therapeutic methods utilizing the polyclonal antibody. Finally, the invention also pertains to a method for screening for useful VH and VL pairs useful when preparing the polyclonal antibody.
Abstract translation: 公开了一种抗正痘病毒重组多克隆抗体，其包含能够结合至少三种正痘病毒相关抗原的不同成员，包含该抗体的药物组合物及其制备方法。 还公开了能够产生重组多克隆抗体作为利用多克隆抗体的治疗方法的多克隆细胞系。 最后，本发明还涉及筛选在制备多克隆抗体时有用的有用的VH和VL对的方法。
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公开(公告)号：US20080069822A1
公开(公告)日：2008-03-20
申请号：US11633070
申请日：2006-12-04
Applicant: Allan Jensen , Johan Lantto , Margit Hansen , Lone Rasmussen , Soren Rasmussen , Lucilla Steinaa
Inventor： Allan Jensen , Johan Lantto , Margit Hansen , Lone Rasmussen , Soren Rasmussen , Lucilla Steinaa
CPC classification number: C07K16/081 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92
Abstract: Disclosed is an anti-orthopoxvirus recombinant polyclonal antibody comprising distinct members which in union are capable of binding at least three orthopoxvirus related antigens, a pharmaceutical composition comprising the antibody, and a method for its production. Also disclosed is a polyclonal cell line capable of producing the recombinant polyclonal antibody as therapeutic methods utilizing the polyclonal antibody. Finally, the invention also pertains to a method for screening for useful VH and VL pairs useful when preparing the polyclonal antibody.
Abstract translation: 公开了一种抗正痘病毒重组多克隆抗体，其包含能够结合至少三种正痘病毒相关抗原的不同成员，包含该抗体的药物组合物及其制备方法。 还公开了能够产生重组多克隆抗体作为利用多克隆抗体的治疗方法的多克隆细胞系。 最后，本发明还涉及用于筛选在制备多克隆抗体时有用的有用的V H和V L配对的方法。
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公开(公告)号：US20120009623A1
公开(公告)日：2012-01-12
申请号：US13243768
申请日：2011-09-23
Applicant: Anne B. Tolstrup , Johan Lantto , Finn C. Wiberg , Lars S. Nielsen
Inventor： Anne B. Tolstrup , Johan Lantto , Finn C. Wiberg , Lars S. Nielsen
CPC classification number: C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells are cultured under suitable conditions for expression of the anti-RSV antibody/antibodies. The nucleic acid sequence is introduced into the cells by transfection with expression vectors, which avoid site-specific integration. The present method is suitable for manufacturing recombinant mono- and polyclonal anti-RSV antibodies for therapeutic uses.
Abstract translation: 本发明涉及一种制备重组抗RSV抗体和抗体组合物的方法。 该方法包括获得用变体核酸序列的集合转染的细胞的集合，其中集合中的每个细胞被转染并能够表达一种不同的抗RSV抗体。 在合适的条件下培养细胞以表达抗RSV抗体/抗体。 通过用表达载体转染将核酸序列引入细胞，这避免了位点特异性整合。 本发明的方法适用于制备用于治疗用途的重组单克隆抗体和多克隆抗RSV抗体。
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公开(公告)号：US09155802B2
公开(公告)日：2015-10-13
申请号：US13286471
申请日：2011-11-01
Applicant: Mikkel W. Pedersen , Ida K. Christensen , Johan Lantto , Helle Jacobsen , Michael Kragh
Inventor： Mikkel W. Pedersen , Ida K. Christensen , Johan Lantto , Helle Jacobsen , Michael Kragh
IPC: A61K39/395 , A61K47/48 , C07K16/28 , C07K16/32 , A61K39/00
CPC classification number: C07K16/32 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/48546 , A61K47/48569 , A61K47/6845 , A61K47/6851 , A61K2039/507 , A61N5/10 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3053 , C07K16/3069 , C07K16/40 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76
Abstract: The present invention is directed to improved therapeutics against receptors within the EGFR/ErbB/HER family that more broadly interfere with multiple members of the HER family (pan-HER inhibition). More particularly, the invention is directed to the use of antibody compositions for human cancer therapy. In vitro studies have shown that the antibody compositions of the invention targeting multiple HER family receptors are superior to antibody compositions targeting only one HER family receptor.
Abstract translation: 本发明涉及改善EGFR / ErbB / HER家族内受体的治疗剂，其更广泛地干扰HER家族的多个成员（pan-HER抑制）。 更具体地，本发明涉及抗体组合物用于人类癌症治疗的用途。 体外研究已经显示靶向多种HER家族受体的本发明的抗体组合物优于靶向仅一种HER家族受体的抗体组合物。
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Patent Agency Ranking
6.发明授权Recombinant antibodies for treatment of respiratory syncytial virus infections 失效用于治疗呼吸道合胞病毒感染的重组抗体公开(公告)号：US07879329B2
公开(公告)日：2011-02-01
申请号：US12073538
申请日：2008-03-06
Applicant: Johan Lantto , Henriette Schjønning Nielsen
Inventor： Johan Lantto , Henriette Schjønning Nielsen
IPC: A61K39/42 , A61K39/155
CPC classification number: C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N2760/18511
Abstract: Disclosed are novel polyclonal antibodies, which target respiratory syncytial virus (RSV), as well as novel high affinity antibody molecules reactive with RSV. The polyclonal antibodies may comprise antibody molecules which are reactive with both RSV protein F and RSV protein G, and preferably the polyclonal antibodies target a variety of epitopes on these proteins. The antibody molecules of the invention have shown superior efficacy in vitro and/or in vivo. Also disclosed are methods of producing the antibodies of the invention as well as methods of their use in treatment or prevention of RSV infection.
Abstract translation: 公开了靶向呼吸道合胞病毒（RSV）的新型多克隆抗体，以及与RSV反应的新型高亲和力抗体分子。 多克隆抗体可以包含与RSV蛋白F和RSV蛋白G两者都具有反应性的抗体分子，优选多克隆抗体靶向这些蛋白质上的多种表位。 本发明的抗体分子在体外和/或体内显示出优异的功效。 还公开了产生本发明的抗体的方法以及它们在治疗或预防RSV感染中的用途。
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7.发明申请Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections 审中-公开用于治疗呼吸道合胞病毒感染的重组多克隆抗体公开(公告)号：US20100040606A1
公开(公告)日：2010-02-18
申请号：US11792927
申请日：2007-03-06
Applicant: Johan Lantto , Lucilla Steinaa , Klaus Koefoed
Inventor： Johan Lantto , Lucilla Steinaa , Klaus Koefoed
CPC classification number: C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N2760/18511
Abstract: Disclosed are novel polyclonal antibodies, which target respiratory syncyticilal virus (RSV), and novel high affinity antibody molecules reactive with RSV. The polyclonal antibodies may comprise antibody molecules which are reactive with both RSV protein F and RSV protein G, and preferably the polyclonal antibodies target a variety of epitopes on these proteins. The single antibody molecules of the invention are shown to exhibit affinities which provide for dissociation constants as low as in the picomolar range. Also disclosed are methods of producing the antibodies of the invention as well as methods of their use in treatment for RSV infection.
Abstract translation: 公开了靶向呼吸道合胞体病毒（RSV）的新型多克隆抗体，以及与RSV反应的新型高亲和力抗体分子。 多克隆抗体可以包含与RSV蛋白F和RSV蛋白G两者都具有反应性的抗体分子，优选多克隆抗体靶向这些蛋白质上的多种表位。 本发明的单抗体分子显示出亲和力，其提供的解离常数低于皮摩尔范围。 还公开了制备本发明的抗体的方法以及它们用于治疗RSV感染的方法。
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公开(公告)号：US20120107234A1
公开(公告)日：2012-05-03
申请号：US13286471
申请日：2011-11-01
Applicant: Mikkel W. PEDERSEN , Ida K. CHRISTENSEN , Johan LANTTO , Helle JACOBSEN , Michael KRAGH
Inventor： Mikkel W. PEDERSEN , Ida K. CHRISTENSEN , Johan LANTTO , Helle JACOBSEN , Michael KRAGH
IPC: A61K39/395 , A61K51/10 , C12N15/13 , C12N1/21 , C12N5/10 , C12P21/00 , C12N1/19 , C12N1/15 , A61P35/00 , C12N15/63
CPC classification number: C07K16/32 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/48546 , A61K47/48569 , A61K47/6845 , A61K47/6851 , A61K2039/507 , A61N5/10 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3053 , C07K16/3069 , C07K16/40 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76
Abstract: The present invention is directed to improved therapeutics against receptors within the EGFR/ErbB/HER family that more broadly interfere with multiple members of the HER family (pan-HER inhibition). More particularly, the invention is directed to the use of antibody compositions for human cancer therapy. In vitro studies have shown that the antibody compositions of the invention targeting multiple HER family receptors are superior to antibody compositions targeting only one HER family receptor.
Abstract translation: 本发明涉及改善EGFR / ErbB / HER家族内受体的治疗剂，其更广泛地干扰HER家族的多个成员（pan-HER抑制）。 更具体地，本发明涉及抗体组合物用于人类癌症治疗的用途。 体外研究已经显示靶向多种HER家族受体的本发明的抗体组合物优于靶向仅一种HER家族受体的抗体组合物。
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公开(公告)号：US07850965B2
公开(公告)日：2010-12-14
申请号：US11633070
申请日：2006-12-04
Applicant: Allan Jensen , Johan Lantto , Margit Haahr Hansen , Lone Kjær Rasmussen , Søren Kofoed Rasmussen , Lucilla Steinaa
Inventor： Allan Jensen , Johan Lantto , Margit Haahr Hansen , Lone Kjær Rasmussen , Søren Kofoed Rasmussen , Lucilla Steinaa
CPC classification number: C07K16/081 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92
Abstract: Disclosed is an anti-orthopoxvirus recombinant polyclonal antibody comprising distinct members which in union are capable of binding at least three orthopoxvirus related antigens, a pharmaceutical composition comprising the antibody, and a method for its production. Also disclosed is a polyclonal cell line capable of producing the recombinant polyclonal antibody as therapeutic methods utilizing the polyclonal antibody. Finally, the invention also pertains to a method for screening for useful VH and VL pairs useful when preparing the polyclonal antibody.
Abstract translation: 公开了一种抗正痘病毒重组多克隆抗体，其包含能够结合至少三种正痘病毒相关抗原的不同成员，包含该抗体的药物组合物及其制备方法。 还公开了能够产生重组多克隆抗体作为利用多克隆抗体的治疗方法的多克隆细胞系。 最后，本发明还涉及筛选在制备多克隆抗体时有用的有用的VH和VL对的方法。
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公开(公告)号：US20090137003A1
公开(公告)日：2009-05-28
申请号：US12230885
申请日：2008-09-05
Applicant: Anne B. Tolstrup , Johan Lantto , Finn C. Wiberg , Lars S. Nielsen
Inventor： Anne B. Tolstrup , Johan Lantto , Finn C. Wiberg , Lars S. Nielsen
CPC classification number: C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells are cultured under suitable conditions for expression of the anti-RSV antibody/antibodies. The nucleic acid sequence is introduced into the cells by transfection with expression vectors, which avoid site-specific integration. The present method is suitable for manufacturing recombinant mono- and polyclonal anti-RSV antibodies for therapeutic uses.
Abstract translation: 本发明涉及一种制备重组抗RSV抗体和抗体组合物的方法。 该方法包括获得用变体核酸序列的集合转染的细胞的集合，其中集合中的每个细胞被转染并能够表达一种不同的抗RSV抗体。 在合适的条件下培养细胞以表达抗RSV抗体/抗体。 通过用表达载体转染将核酸序列引入细胞，这避免了位点特异性整合。 本发明的方法适用于制备用于治疗用途的重组单克隆抗体和多克隆抗RSV抗体。
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